Search Results - "De Nardo, Dominic"

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation by Xue, Jia, Schmidt, Susanne V., Sander, Jil, Draffehn, Astrid, Krebs, Wolfgang, Quester, Inga, De Nardo, Dominic, Gohel, Trupti D., Emde, Martina, Schmidleithner, Lisa, Ganesan, Hariharasudan, Nino-Castro, Andrea, Mallmann, Michael R., Labzin, Larisa, Theis, Heidi, Kraut, Michael, Beyer, Marc, Latz, Eicke, Freeman, Tom C., Ulas, Thomas, Schultze, Joachim L.

“…Macrophage activation is associated with profound transcriptional reprogramming. Although much progress has been made in the understanding of macrophage…”
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression by Balic, Jesse J., Albargy, Hassan, Luu, Kevin, Kirby, Francis J., Jayasekara, W. Samantha N., Mansell, Finbar, Garama, Daniel J., De Nardo, Dominic, Baschuk, Nikola, Louis, Cynthia, Humphries, Fiachra, Fitzgerald, Katherine, Latz, Eicke, Gough, Daniel J., Mansell, Ashley

“…Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response…”
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Deficiency in coatomer complex I causes aberrant activation of STING signalling by Steiner, Annemarie, Hrovat-Schaale, Katja, Prigione, Ignazia, Yu, Chien-Hsiung, Laohamonthonkul, Pawat, Harapas, Cassandra R., Low, Ronnie Ren Jie, De Nardo, Dominic, Dagley, Laura F., Mlodzianoski, Michael J., Rogers, Kelly L., Zillinger, Thomas, Hartmann, Gunther, Gantier, Michael P., Gattorno, Marco, Geyer, Matthias, Volpi, Stefano, Davidson, Sophia, Masters, Seth L.

“…Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in…”
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Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence by Beilharz, Michael, De Nardo's, Dominic, Latz, Eicke, Franklin, Bernardo S

“…Inflammasome assembly results in the formation of a large intracellular protein scaffold driven by the oligomerization of the adaptor protein…”
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Understanding early TLR signaling through the Myddosome by Balka, Katherine R., Nardo, Dominic

“…TLRs are expressed on the plasma and endosomal membranes of innate immune cells acting as sensors of foreign and inherent danger signals that threaten the…”
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Immortalization of Murine Bone Marrow-Derived Macrophages by De Nardo, Dominic, Kalvakolanu, Dhan V, Latz, Eicke

“…Macrophages are specialized phagocytes that display a variety of important functions for the host immune system. They are particularly important for the…”
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The Inflammasomes and Autoinflammatory Syndromes by Broderick, Lori, De Nardo, Dominic, Franklin, Bernardo S, Hoffman, Hal M, Latz, Eicke

“…Inflammation, a vital response of the immune system to infection and damage to tissues, can be initiated by various germline-encoded innate immune-signaling…”
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Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner by Conos, Stephanie A., Chen, Kaiwen W., De Nardo, Dominic, Hara, Hideki, Whitehead, Lachlan, Núñez, Gabriel, Masters, Seth L., Murphy, James M., Schroder, Kate, Vaux, David L., Lawlor, Kate E., Lindqvist, Lisa M., Vince, James E.

“…Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase…”
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells by Balka, Katherine R., Louis, Cynthia, Saunders, Tahnee L., Smith, Amber M., Calleja, Dale J., D’Silva, Damian B., Moghaddas, Fiona, Tailler, Maximilien, Lawlor, Kate E., Zhan, Yifan, Burns, Christopher J., Wicks, Ian P., Miner, Jonathan J., Kile, Benjamin T., Masters, Seth L., De Nardo, Dominic

“…Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages by Li, Zhipeng, Gurung, Manoj, Rodrigues, Richard R, Padiadpu, Jyothi, Newman, Nolan K, Manes, Nathan P, Pederson, Jacob W, Greer, Renee L, Vasquez-Perez, Stephany, You, Hyekyoung, Hioki, Kaito A, Moulton, Zoe, Fel, Anna, De Nardo, Dominic, Dzutsev, Amiran K, Nita-Lazar, Aleksandra, Trinchieri, Giorgio, Shulzhenko, Natalia, Morgun, Andrey

“…Microbiota contribute to the induction of type 2 diabetes by high-fat/high-sugar (HFHS) diet, but which organs/pathways are impacted by microbiota remain…”
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ATF3 Is a Key Regulator of Macrophage IFN Responses by Labzin, Larisa I, Schmidt, Susanne V, Masters, Seth L, Beyer, Marc, Krebs, Wolfgang, Klee, Kathrin, Stahl, Rainer, Lütjohann, Dieter, Schultze, Joachim L, Latz, Eicke, De Nardo, Dominic

“…Cytokines and IFNs downstream of innate immune pathways are critical for mounting an appropriate immune response to microbial infection. However, the…”
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Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface by Moghaddas, Fiona, Zeng, Ping, Zhang, Yuxia, Schützle, Heike, Brenner, Sebastian, Hofmann, Sigrun R., Berner, Reinhard, Zhao, Yuanbo, Lu, Bingtai, Chen, Xiaoyun, Zhang, Li, Cheng, Suyun, Winkler, Stefan, Lehmberg, Kai, Canna, Scott W., Czabotar, Peter E., Wicks, Ian P., De Nardo, Dominic, Hedrich, Christian M., Zeng, Huasong, Masters, Seth L.

“…Monogenic autoinflammatory disorders are characterized by dysregulation of the innate immune system, for example by gain-of-function mutations in…”
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A Mutation Outside the Dimerization Domain Causing Atypical STING-Associated Vasculopathy With Onset in Infancy by Saldanha, Rohit G, Balka, Katherine R, Davidson, Sophia, Wainstein, Brynn K, Wong, Melanie, Macintosh, Rebecca, Loo, Christine K C, Weber, Martin A, Kamath, Vasanth, Moghaddas, Fiona, De Nardo, Dominic, Gray, Paul Edgar, Masters, Seth Lucian

“…Mutations in the gene encoding stimulator of interferon genes (STING) underlie a type I interferon (IFN) associated disease, STING-associated vasculopathy with…”
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Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses by Pépin, Geneviève, De Nardo, Dominic, Rootes, Christina L, Ullah, Tomalika R, Al-Asmari, Sumaiah S, Balka, Katherine R, Li, Hong-Mei, Quinn, Kylie M, Moghaddas, Fiona, Chappaz, Stephane, Kile, Benjamin T, Morand, Eric F, Masters, Seth L, Stewart, Cameron R, Williams, Bryan R G, Gantier, Michael P

“…Activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in antiviral responses to many DNA viruses. Sensing of cytosolic DNA by cGAS results…”
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Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use by Sun, Jing, Li, Ning, Oh, Kyu-Seon, Dutta, Bhaskar, Vayttaden, Sharat J, Lin, Bin, Ebert, Thomas S, De Nardo, Dominic, Davis, Joie, Bagirzadeh, Rustam, Lounsbury, Nicolas W, Pasare, Chandrashekhar, Latz, Eicke, Hornung, Veit, Fraser, Iain D C

“…Toll-like receptors (TLRs) are a major class of pattern recognition receptors, which mediate the responses of innate immune cells to microbial stimuli. To…”
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Signaling Crosstalk during Sequential TLR4 and TLR9 Activation Amplifies the Inflammatory Response of Mouse Macrophages by De Nardo, Dominic, De Nardo, Christine M, Nguyen, Thao, Hamilton, John A, Scholz, Glen M

“…The TLR family of pattern recognition receptors is largely responsible for meditating the activation of macrophages by pathogens. Because macrophages may…”
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Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations by Pang, Ee Shan, Daraj, Ghazal, Balka, Katherine R, De Nardo, Dominic, Macri, Christophe, Hochrein, Hubertus, Masterman, Kelly-Anne, Tan, Peck S, Shoppee, Angus, Magill, Zoe, Jahan, Nazneen, Bafit, Mariam, Zhan, Yifan, Kile, Benjamin T, Lawlor, Kate E, Radford, Kristen J, Wright, Mark D, O'Keeffe, Meredith

“…Stimulator of Interferon Genes (STING) is a cytosolic sensor of cyclic dinucleotides (CDNs). The activation of dendritic cells (DC) the STING pathway, and…”
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Genistein Targets STING-Driven Antiviral Responses by Ullah, Tomalika R., Balka, Katherine R., Ambrose, Rebecca L., Pépin, Geneviève, Wilce, Matthew C. J., Wilce, Jacqueline A., Thomas, Belinda J., De Nardo, Dominic, Williams, Bryan R. G., Gantier, Michael P.

“…Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the…”
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Editorial: Immunomodulation of Innate Immune Cells by Almeida, Catarina R, Bottazzi, Barbara, De Nardo, Dominic, Lawlor, Kate E

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