Search Results - "De Morais, S M"

Biofilm of Candida albicans: formation, regulation and resistance by Pereira, R., Santos Fontenelle, R.O., Brito, E.H.S., Morais, S.M.

“…Summary Candida albicans is the most common human fungal pathogen, causing infections that range from mucous membranes to systemic infections. The present…”
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Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study by Feng, B, Obach, RS, Burstein, AH, Clark, DJ, Morais, SM, Faessel, HM

“…Varenicline is predominantly eliminated unchanged in urine, and active tubular secretion partially contributes to its renal elimination. Transporter inhibition…”
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HIV‐1 subtype frequency in Northeast Brazil: A systematic review and meta‐analysis by Costa, Clevson P., Rodrigues, Jessyca K. F., Morais, Viviane M. S., Andrade, Carlos A. d. N., Neves, Patrícia A. F., Lima, Kledoaldo

“…Information on human immunodeficiency virus (HIV) molecular epidemiology is required to verify HIV/AIDS (acquired immune deficiency syndrome) epidemic dynamics…”
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Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans by Shen, Jianwei, Serby, Michael, Surber, Bruce, Lee, Anthony J, Ma, Junli, Badri, Prajakta, Menon, Rajeev, Kavetskaia, Olga, de Morais, Sonia M, Sydor, Jens, Fischer, Volker

“…Ombitasvir (also known as ABT-267) is a potent inhibitor of hepatitis C virus (HCV) nonstructural protein 5A (NS5A), which has been developed in combination…”
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Effects of essential oil of Alpinia zerumbet on the compound action potential of the rat sciatic nerve by Leal-Cardoso, J.H., Moreira, M.R., Pinto da Cruz, G.M., de Morais, S.M., Lahlou, M.S., Coelho-de-Souza, A.N.

“…Alpinia zerumbet, known popularly as “colônia” in Northeastern Brazil, is a medicinal plant that has been used widely in folk medicine as teas and infusions…”
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Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe by Kaminsky, L S, de Morais, S M, Faletto, M B, Dunbar, D A, Goldstein, J A

“…The regio- and stereoselectivity of warfarin metabolism have been used to assess structure-function relationships of human P4502C subfamily members. Metabolism…”
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The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans by de Morais, S M, Wilkinson, G R, Blaisdell, J, Nakamura, K, Meyer, U A, Goldstein, J A

“…The metabolism of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans, with the poor metabolizer trait being inherited in an…”
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Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese by De Morais, S M, Wilkinson, G R, Blaisdell, J, Meyer, U A, Nakamura, K, Goldstein, J A

“…A genetic polymorphism in the metabolism of the anticonvulsant drug (S)-mephenytoin has been well documented in humans. There are marked interracial…”
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Croton sonderianus essential oil samples distinctly affect rat airway smooth muscle by Pinho-da-Silva, L., Mendes-Maia, P.V., do Nascimento Garcia, T.M., Cruz, J.S., de Morais, S.M., Coelho-de-Souza, A.N., Lahlou, S., Leal-Cardoso, J.H.

“…Plants of the genus Croton have been used extensively in the northeast of Brazil for treating various clinical conditions. Previous studies have demonstrated…”
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Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity by de Morais, S M, Wells, P G

“…Over 60% of the analgesic/antipyretic drug acetaminophen is eliminated by glucuronidation, which competes with a toxifying pathway involving cytochromes…”
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Genetic analysis of the S-mephenytoin polymorphism in a Chinese population by de Morais, S M, Goldstein, J A, Xie, H G, Huang, S L, Lu, Y Q, Xia, H, Xiao, Z S, Ile, N, Zhou, H H

“…The 4'-hydroxylation of S-mephenytoin exhibits a polymorphism in humans, with the poor metabolizer phenotype exhibiting a lower frequency in white (3% to 5%)…”
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Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18 by de Morais, S M, Schweikl, H, Blaisdell, J, Goldstein, J A

“…There is a genetic polymorphism in humans in the metabolism of S-mephenytoin which has been suggested to be mediated by either CYP2C18 or CYP2C9. We have…”
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Photoaffinity labeling of the Ah receptor with 3-[3H]methylcholanthrene and formation of a 165-kDa complex between the ligand-binding subunit and a novel cytosolic protein by de Morais, S M, Giannone, J V, Okey, A B

“…The aromatic hydrocarbon (Ah) receptor is a cytosolic protein that binds halogenated ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and…”
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In Vitro P-glycoprotein Assays to Predict the in Vivo Interactions of P-glycoprotein with Drugs in the Central Nervous System by BO FENG, MILLS, Jessica B, DAVIDSON, Ralph E, MIRELES, Rouchelle J, JANISZEWSKI, John S, TROUTMAN, Matthew D, DE MORAIS, Sonia M

“…Thirty-one structurally diverse marketed central nervous system (CNS)-active drugs, one active metabolite, and seven non-CNS-active compounds were tested in…”
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The orofacial antinociceptive effect of Kaempferol-3-O-rutinoside, isolated from the plant Ouratea fieldingiana, on adult zebrafish (Danio rerio) by do Nascimento, José Eranildo Teles, de Morais, Selene Maia, de Lisboa, Daniele Silva, de Oliveira Sousa, Matheus, Santos, Sacha Aubrey Alves Rodrigues, Magalhães, Francisco Ernani Alves, Campos, Adriana Rolim

“…•The antinociceptive effect of Kaempferol-3-O-rutinoside was similar to morphine.•Kaempferol-3-O-rutinoside has potential for the treatment of acute orofacial…”
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Contact dermatitis among cashew nut workers by Diogenes, M J, de Morais, S M, Carvalho, F F

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Ethanol Dissipates the Proton-motive Force across the Plasma Membrane of Saccharomyces cerevisiae by Cartwright, Charles P, juroszek, Jean-Regis, Beavan, Michael J, Ruby, Fiona M. S, De Morais, Sonia M. F, Rose, Anthony H

“…Zymology Laboratory, School of Biological Sciences, University of Bath, Bath BA2 7AY, Avon, UK ABSTRACT Summary: Populations of Saccharomyces cerevisiae NCYC…”
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Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase by de Morais, S M, Chow, S Y, Wells, P G

“…Acetaminophen is eliminated primarily by glucuronidation, thereby avoiding cytochrome P450-catalyzed bioactivation to a toxic reactive intermediate. Previous…”
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Enhanced acetaminophen toxicity in rats with bilirubin glucuronyl transferase deficiency by de Morais, S M, Wells, P G

“…Glucuronidation is the major pathway for elimination of acetaminophen, diverting it from the toxifying pathway catalyzed by cytochromes P-450. A genetic…”
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Larvicidal Activity of Essential Oils from Brazilian Plants against Aedes aegypti L by Cavalcanti, Eveline Solon Barreira, Morais, Selene Maia de, Lima, Michele Ashley A, Santana, Eddie William Pinho

“…Aedes aegypti L. is the major vector of dengue fever, an endemic disease in Brazil. In an effort to find effective and affordable ways to control this…”
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