Search Results - "De Mol, Maria"

Fibrinolysis‐independent role of plasmin and its activators in the haematopoietic recovery after myeloablation by Tjwa, Marc, Moura, Rute, Moons, Lieve, Plaisance, Stephane, Mol, Maria De, Jansen, Sandra, Dewerchin, Mieke, Verfaillie, Catherine, Carmeliet, Peter

“…Proteinases have been implicated in the mobilization of haematopoietic progenitor cells (HPCs) from the bone marrow (BM). Here, we report the involvement of…”
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HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF by Rolny, Charlotte, Mazzone, Massimiliano, Tugues, Sònia, Laoui, Damya, Johansson, Irja, Coulon, Cathy, Squadrito, Mario Leonardo, Segura, Inmaculada, Li, Xiujuan, Knevels, Ellen, Costa, Sandra, Vinckier, Stefan, Dresselaer, Tom, Åkerud, Peter, De Mol, Maria, Salomäki, Henriikka, Phillipson, Mia, Wyns, Sabine, Larsson, Erik, Buysschaert, Ian, Botling, Johan, Himmelreich, Uwe, Van Ginderachter, Jo A., De Palma, Michele, Dewerchin, Mieke, Claesson-Welsh, Lena, Carmeliet, Peter

“…Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks…”
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Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels by Fischer, Christian, Jonckx, Bart, Mazzone, Massimiliano, Zacchigna, Serena, Loges, Sonja, Pattarini, Lucia, Chorianopoulos, Emmanuel, Liesenborghs, Laurens, Koch, Marta, De Mol, Maria, Autiero, Monica, Wyns, Sabine, Plaisance, Stephane, Moons, Lieve, van Rooijen, Nico, Giacca, Mauro, Stassen, Jean-Marie, Dewerchin, Mieke, Collen, Desire, Carmeliet, Peter

“…Novel antiangiogenic strategies with complementary mechanisms are needed to maximize efficacy and minimize resistance to current angiogenesis inhibitors. We…”
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Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1 + Leukemia by Schmidt, Thomas, Masouleh, Behzad Kharabi, Loges, Sonja, Cauwenberghs, Sandra, Fraisl, Peter, Maes, Christa, Jonckx, Bart, De Keersmaecker, Kim, Kleppe, Maria, Tjwa, Marc, Schenk, Thomas, Vinckier, Stefan, Fragoso, Rita, De Mol, Maria, Beel, Karolien, Dias, Sérgio, Verfaillie, Catherine, Clark, Richard E., Brümmendorf, Tim H., Vandenberghe, Peter, Rafii, Shahin, Holyoake, Tessa, Hochhaus, Andreas, Cools, Jan, Karin, Michael, Carmeliet, Geert, Dewerchin, Mieke, Carmeliet, Peter

“…Imatinib has revolutionized the treatment of B cr-A bl1 + chronic myeloid leukemia (CML), but, in most patients, some leukemia cells persist despite continued…”
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Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS by Carmeliet, Peter, Storkebaum, Erik, Lambrechts, Diether, Dewerchin, Mieke, Moreno-Murciano, Maria-Paz, Appelmans, Saskia, Oh, Hideyasu, Van Damme, Philip, Rutten, Bart, Man, Wing Yan, De Mol, Maria, Wyns, Sabine, Manka, David, Vermeulen, Kristel, Van Den Bosch, Ludo, Mertens, Nico, Schmitz, Christoph, Robberecht, Wim, Conway, Edward M, Collen, Désiré, Moons, Lieve

“…Neurotrophin treatment has so far failed to prolong the survival of individuals affected with amyotrophic lateral sclerosis (ALS), an incurable motoneuron…”
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Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 by Carmeliet, Peter, Autiero, Monica, Waltenberger, Johannes, Communi, Didier, Kranz, Andrea, Moons, Lieve, Lambrechts, Diether, Kroll, Jens, Plaisance, Stephane, De Mol, Maria, Bono, Françoise, Kliche, Stefanie, Fellbrich, Guido, Ballmer-Hofer, Kurt, Maglione, Domenico, Mayr-Beyrle, Ulrike, Dewerchin, Mieke, Dombrowski, Saskia, Stanimirovic, Danica, Van Hummelen, Paul, Dehio, Christoph, Hicklin, Daniel J, Persico, Graziella, Herbert, Jean-Marc, Communi, David, Shibuya, Masabumi, Collen, Désiré, Conway, Edward M

“…Therapeutic angiogenesis is likely to require the administration of factors that complement each other. Activation of the receptor tyrosine kinase (RTK) Flk1…”
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Depletion of circulating α2-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization by Nagai, Nobus, De Mol, Maria, Van Hoef, Berthe, Verstreken, Maria, Collen, Désiré

“…In the absence of arterial recanalization, thrombolytic agents induce a dose-related extension of focal cerebral ischemic injury (FII) in experimental animals…”
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HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PIGF by Rolny, Charlotte, Mazzone, Massimiliano, Tugues, Sònia, Laoui, Damya, Johansson, Irja, Coulon, Cathy, Squadrito, Mario Leonardo, Segura, Inmaculada, Li, Xiujuan, Knevels, Ellen, Costa, Sandra, Vinckier, Stefan, Dresselaer, Tom, Åkerud, Peter, De Mol, Maria, Salomäki, Henriikka, Phillipson, Mia, Wyns, Sabine, Larsson, Erik, Buysschaert, Ian, Botling, Johan, Himmelreich, Uwe, Van Ginderachter, Jo A., De Palma, Michele, Dewerchin, Mieke, Claesson-Welsh, Lena, Carmeliet, Peter

“…Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks…”
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Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease by Van de Veire, Sara, Stalmans, Ingeborg, Heindryckx, Femke, Oura, Hajimu, Tijeras-Raballand, Annemilaï, Schmidt, Thomas, Loges, Sonja, Albrecht, Imke, Jonckx, Bart, Vinckier, Stefan, Van Steenkiste, Christophe, Tugues, Sònia, Rolny, Charlotte, De Mol, Maria, Dettori, Daniela, Hainaud, Patricia, Coenegrachts, Lieve, Contreres, Jean-Olivier, Van Bergen, Tine, Cuervo, Henar, Xiao, Wei-Hong, Le Henaff, Carole, Buysschaert, Ian, Masouleh, Behzad Kharabi, Geerts, Anja, Schomber, Tibor, Bonnin, Philippe, Lambert, Vincent, Haustraete, Jurgen, Zacchigna, Serena, Rakic, Jean-Marie, Jiménez, Wladimiro, Noël, Agnes, Giacca, Mauro, Colle, Isabelle, Foidart, Jean-Michel, Tobelem, Gerard, Morales-Ruiz, Manuel, Vilar, José, Maxwell, Patrick, Vinores, Stanley A., Carmeliet, Geert, Dewerchin, Mieke, Claesson-Welsh, Lena, Dupuy, Evelyne, Van Vlierberghe, Hans, Christofori, Gerhard, Mazzone, Massimiliano, Detmar, Michael, Collen, Désiré, Carmeliet, Peter

“…Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of…”
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Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia by Schmidt, Thomas, Kharabi Masouleh, Behzad, Loges, Sonja, Cauwenberghs, Sandra, Fraisl, Peter, Maes, Christa, Jonckx, Bart, De Keersmaecker, Kim, Kleppe, Maria, Tjwa, Marc, Schenk, Thomas, Vinckier, Stefan, Fragoso, Rita, De Mol, Maria, Beel, Karolien, Dias, Sérgio, Verfaillie, Catherine, Clark, Richard E., Brümmendorf, Tim H., Vandenberghe, Peter, Rafii, Shahin, Holyoake, Tessa, Hochhaus, Andreas, Cools, Jan, Karin, Michael, Carmeliet, Geert, Dewerchin, Mieke, Carmeliet, Peter

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Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells by Tjwa, Marc, Sidenius, Nicolai, Moura, Rute, Jansen, Sandra, Theunissen, Koen, Andolfo, Annapaola, De Mol, Maria, Dewerchin, Mieke, Moons, Lieve, Blasi, Francesco, Verfaillie, Catherine, Carmeliet, Peter

“…The mechanisms of BM hematopoietic stem/progenitor cell (HSPC) adhesion, engraftment, and mobilization remain incompletely identified. Here, using WT and…”
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Reactivated recombinant plasminogen activator inhibitor-1 (rPAI-1) effectively prevents thrombolysis in vivo by Vaughan, D E, Declerck, P J, Van Houtte, E, De Mol, M, Collen, D

“…The effects of human recombinant plasminogen activator inhibitor (rPAI-1) on thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) were…”
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Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions by Carmeliet, Peter, Moons, Lieve, Luttun, Aernout, Vincenti, Valeria, Compernolle, Veerle, De Mol, Maria, Wu, Yan, Bono, Françoise, Devy, Laetitia, Beck, Heike, Scholz, Dimitri, Acker, Till, DiPalma, Tina, Dewerchin, Mieke, Noel, Agnes, Stalmans, Ingeborg, Barra, Adriano, Blacher, Sylvia, Vandendriessche, Thierry, Ponten, Annica, Eriksson, Ulf, Plate, Karl H, Foidart, Jean-Michel, Schaper, Wolfgang, Charnock-Jones, D. Stephen, Hicklin, Daniel J, Herbert, Jean-Marc, Collen, Désiré, Persico, M. Graziella

“…Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEGFR-2). The role of its homolog, placental growth factor…”
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VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation by Meissirel, Claire, Ruiz de Almodovar, Carmen, Knevels, Ellen, Coulon, Cathy, Chounlamountri, Naura, Segura, Inmaculada, de Rossi, Pierre, Vinckier, Stefan, Anthonis, Kristof, Deléglise, Bérangère, de Mol, Maria, Ali, Carine, Dassonville, Karel, Loyens, Ellen, Honnorat, Jérôme, Michotte, Yvette, Rogemond, Véronique, Smolders, Ilse, Voets, Thomas, Vivien, Denis, Vanden Berghe, Pieter, Van Den Bosch, Ludo, Robberecht, Wim, Chédotal, Alain, Oliviero, Salvatore, Dewerchin, Mieke, Schmucker, Dietmar, Thomasset, Nicole, Salin, Paul, Carmeliet, Peter

“…NMDA type glutamate receptors (NMDARs) are best known for their role in synaptogenesis and synaptic plasticity. Much less is known about their developmental…”
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Machine learning to further improve the decision which boar ejaculates to process into artificial insemination doses by Kamphuis, Claudia, Duenk, Pascal, Veerkamp, Roel Franciscus, Visser, Bram, Singh, Gurnoor, Nigsch, Annette, De Mol, Rudi Maria, Broekhuijse, Marleen Leonarda Wilhelmina Johanna

“…Current artificial insemination (AI) laboratory practices assess semen quality of each boar ejaculate to decide which ones to process into AI doses. This…”
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VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation by Meissirel, Claire, Ruiz de Almodovar, Carmen, Knevels, Ellen, Coulon, Cathy, Chounlamountri, Naura, Segura, Inmaculada, de Rossi, Pierre, Vinckier, Stefan, Anthonis, Kristof, Deléglise, Bérangère, de Mol, Maria, Ali, Carine, Dassonville, Karel, Loyens, Ellen, Honnorat, Jérôme, Michotte, Yvette, Rogemond, Véronique, Smolders, Ilse, Voets, Thomas, Vivien, Denis, Vanden Berghe, Pieter, van den Bosch, Ludo, Robberecht, Wim, Chédotal, Alain, Oliviero, Salvatore, Dewerchin, Mieke, Schmucker, Dietmar, Thomasset, Nicole, Salin, Paul, Carmeliet, Peter

“…NMDA type glutamate receptors (NMDARs) are best known for their role in synaptogenesis and synaptic plasticity. Much less is known about their developmental…”
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Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis by Carmeliet, P, Stassen, J M, Schoonjans, L, Ream, B, van den Oord, J J, De Mol, M, Mulligan, R C, Collen, D

“…The effects of plasminogen activator inhibitor-1 (PAI-1) gene inactivation on hemostasis, thrombosis and thrombolysis were studied in homozygous…”
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Vascular wound healing and neointima formation induced by perivascular electric injury in mice by Carmeliet, P, Moons, L, Stassen, JM, De Mol, M, Bouche, A, van den Oord, JJ, Kockx, M, Collen, D

“…Vascular interventions for atherothrombotic disease frequently induce neointima formation, which can contribute to restenosis of blood vessels. As the…”
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Abstract LB-362: PlGF inhibition phenocopies PlGF deficiency in cancer by Schmidt, Thomas, Van de Veire, Sara, Heindryckx, Femke, Oura, Hajimu, Tijeras-Raballand, Annemilaï, Loges, Sonja, Albrecht, Imke, Jonckx, Bart, Vinckier, Stefan, Van Steenkiste, Christophe, Tugues, Sònia, Rolny, Charlotte, De Mol, Maria, Dettori, Daniela, Hainaud, Patricia, Coenegrachts, Lieve, Contreres, Jean-Olivier, Cuervo, Henar, Henaff, Carole Le, Buysschaert, Ian, Masouleh, Behzad Kharabi, Geerts, Anja, Schomber, Tibor, Bonnin, Philippe, Haustraete, Juergen, Zacchigna, Serena, Jiménez, Wladimiro, Giacca, Mauro, Colle, Isabelle, Tobelem, Gerard, Morales-Ruiz, Manuel, Vilar, José, Carmeliet, Geert, Dewerchin, Mieke, Claesson-Welsh, Lena, Dupuy, Evelyne, Van Vlierberghe, Hans, Christofori, Gerhard, Mazzone, Massimiliano, Detmar, Michael, Collen, Désiré, Carmeliet, Peter

“…Abstract To overcome the resistance to VEGF-inhibitor treatment, additional anti-angiogenic agents need to be valorized. Placental growth factor (PlGF), a VEGF…”
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Targeted Deletion of the Cytosolic Domain of Tissue Factor in Mice Does Not Affect Development by Melis, Els, Moons, Lieve, De Mol, Maria, Herbert, Jean-Marc, Mackman, Nigel, Collen, Désiré, Carmeliet, Peter, Dewerchin, Mieke

“…The role of the cytosolic domain of tissue factor (TF) in signal transduction and gene regulation was studied in mice with a targeted deletion of the 18…”
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