Search Results - "De Miguel Luken, Maria J"

Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors by Yap, Timothy A, O'Carrigan, Brent, Penney, Marina S, Lim, Joline S, Brown, Jessica S, de Miguel Luken, Maria J, Tunariu, Nina, Perez-Lopez, Raquel, Rodrigues, Daniel Nava, Riisnaes, Ruth, Figueiredo, Ines, Carreira, Suzanne, Hare, Brian, McDermott, Katherine, Khalique, Saira, Williamson, Chris T, Natrajan, Rachael, Pettitt, Stephen J, Lord, Christopher J, Banerji, Udai, Pollard, John, Lopez, Juanita, de Bono, Johann S

“…Preclinical studies demonstrated that ATR inhibition can exploit synthetic lethality (eg, in cancer cells with impaired compensatory DNA damage responses…”
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors by Kim, Tae Won, Burris, Howard A, de Miguel Luken, Maria J, Pishvaian, Michael J, Bang, Yung-Jue, Gordon, Michael, Awada, Ahmad, Camidge, D Ross, Hodi, F Stephen, McArthur, Grant A, Miller, Wilson H, Cervantes, Andres, Chow, Laura Q, Lesokhin, Alexander M, Rutten, Annemie, Sznol, Mario, Rishipathak, Deepali, Chen, Shang-Chiung, Stefanich, Eric, Pourmohamad, Tony, Anderson, Maria, Kim, Jeong, Huseni, Mahrukh, Rhee, Ina, Siu, Lillian L

“…OX40, a receptor transiently expressed by T cells upon antigen recognition, is associated with costimulation of effector T cells and impairment of regulatory…”
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A phase I safety and efficacy clinical trial of plocabulin and gemcitabine in patients with advanced solid tumors by Ghalib, Mohammad H, Pulla, Mariano Provencio, De Miguel Luken, Maria J, de Juan, Virginia Calvo, Chaudhary, Imran, Hammami, M Bakri, Vikash, Sindhu, Maitra, Radhashree, Martinez, Sara, Kahatt, Carmen, Extremera, Sonia, Fudio, Salvador, Goel, Sanjay

“…Plocabulin (Plo) induces depolymerization of tubulin fibers with disorganization and fragmentation of the microtubule network leading to mitosis. Plo combined…”
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Immunotherapy-based combinations: current status and perspectives by de Miguel-Luken, María J, Mansinho, André, Boni, Valentina, Calvo, Emiliano

“…Since the approval of ipilimumab, different immune checkpoint inhibitors, vaccines and costimulatory agonists have been developed with success, improving…”
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Abstract LBA038: KontRASt: A Phase Ib/II, open-label, multi-center, dose-escalation study of JDQ443 in patients with advanced solid tumors harboring the KRAS G12C mutation by Solomon, Benjamin, Heist, Rebecca S, Tan, Daniel SW, Cassier, Philippe A, Dooms, Christophe, Van Cutsem, Eric, Steuer, Conor E, Steeghs, Neeltje, Schuler, Martin, Gazzah, Anas, Wermke, Martin, Felip, Enriqueta, Loong, Herbert HF, De Miguel Luken, Maria J, Soo, Ross A, Jaeger, Ashley, Xu, Kun, Chen, Xueying, Cui, Xiaoming, Burks, Heather, Farago, Anna F, Shimizu, Toshio

“…Abstract Background Kirsten rat sarcoma virus (KRAS) is a GTPase that regulates cell signaling pathways involved in cell proliferation, survival, and…”
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Abstract CT033: KontRASt-01: A phase Ib/II, dose-escalation study of JDQ443 in patients (pts) with advanced, KRAS G12C-mutated solid tumors by Tan, Daniel S., Shimizu, Toshio, Solomon, Benjamin, Heist, Rebecca S., Schuler, Martin, Luken, Maria J. De Miguel, Gazzah, Anas, Wermke, Martin, Dooms, Christophe, Loong, Herbert H., Steeghs, Neeltje, Felip, Enriqueta, Steuer, Conor E., van Cutsem, Eric, Soo, Ross A., Jaeger, Ashley C., Kim, Jaeyeon, Xu, Kun, Chen, Xueying, Cui, Xiaoming, Burks, Heather, Farago, Anna, Cassier, Philippe A.

“…Abstract Background: KRAS G12C oncogenic mutations occur in ~13% of non-small cell lung cancers (NSCLCs) and up to 4% of other solid tumors. JDQ443 is a…”
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Abstract PR14: Phase I trial of first-in-class ataxia telangiectasia-mutated and Rad3-related (ATR) inhibitor VX-970 as monotherapy (mono) or in combination with carboplatin (CP) in advanced cancer patients (pts) with preliminary evidence of target modulation and antitumor activity by Yap, Timothy A., Luken, Maria J. de Miguel, O'Carrigan, Brent, Roda, Desam, Papadatos-Pastos, Dionysis, Lorente, David, Tunariu, Nina, Lopez, Raquel Perez, Gayle, Sasha, Riisnaes, Ruth, Figueiredo, Ines, Miranda, Susana, Carreira, Suzanne, Yang, Fang, Karan, Sharon, Penney, Marina, Pollard, John, Molife, L. Rhoda, Banerji, Udai, Asmal, Mohammed, Fields, Scott Z., Bono, Johann S. de

“…Abstract Background: ATR mediates the homologous recombination DNA repair pathway and cellular response to replication stress. VX-970 is a potent and selective…”
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