Search Results - "De Mey, Sven"
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Immunomodulation of the Tumor Microenvironment: Turn Foe Into Friend
Published in Frontiers in immunology (11-12-2018)“…Immunotherapy, where the patient's own immune system is exploited to eliminate tumor cells, has become one of the most prominent new cancer treatment options…”
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Radioresistance of Human Cancers: Clinical Implications of Genetic Expression Signatures
Published in Frontiers in oncology (27-10-2021)“…Although radiotherapy is given to more than 50% of cancer patients, little progress has been made in identifying optimal radiotherapy - drug combinations to…”
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3
Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells
Published in International journal of molecular sciences (09-12-2020)“…Mitochondrial metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways can potentially sensitize tumors with limited treatment…”
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Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption
Published in Frontiers in pharmacology (03-10-2018)“…The anti-diabetic biguanide drugs metformin and phenformin exhibit antitumor activity in various models. However, their radiomodulatory effect under hypoxic…”
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Transcutaneous Vagal Nerve Stimulation Alone or in Combination With Radiotherapy Stimulates Lung Tumor Infiltrating Lymphocytes But Fails to Suppress Tumor Growth
Published in Frontiers in immunology (01-12-2021)“…The combination of radiotherapy (RT) with immunotherapy represents a promising treatment modality for non-small cell lung cancer (NSCLC) patients. As only a…”
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Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems
Published in Cancer letters (28-05-2019)“…Piperlongumine (PL), naturally synthesized in long pepper, is known to selectively kill tumor cells via perturbation of reactive oxygen species (ROS)…”
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Fractionated Radiation Severely Reduces the Number of CD8+ T Cells and Mature Antigen Presenting Cells Within Lung Tumors
Published in International journal of radiation oncology, biology, physics (01-09-2021)“…The combination of standard-of-care radiation therapy (RT) with immunotherapy is moving to the mainstream of non-small cell lung cancer treatment. Multiple…”
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Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
Published in Oncotarget (30-05-2017)“…Auranofin (AF) is an anti-arthritic drug considered for combined chemotherapy due to its ability to impair the redox homeostasis in tumor cells. In this study,…”
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Inhibition of Phosphoglycerate Dehydrogenase Radiosensitizes Human Colorectal Cancer Cells under Hypoxic Conditions
Published in Cancers (15-10-2022)“…Augmented de novo serine synthesis activity is increasingly apparent in distinct types of cancers and has mainly sparked interest by investigation of…”
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Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer
Published in Radiotherapy and oncology (01-06-2018)“…The management of locally advanced rectal cancer has passed a long way of developments, where total mesorectal excision and preoperative radiotherapy are…”
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