Search Results - "De Mey, Jo G.R"

Calcitonin Gene-Related Peptide Terminates Long-Lasting Vasopressor Responses to Endothelin 1 In Vivo by Meens, Merlijn J.P.M.T, Mattheij, Nadine J.A, Nelissen, Jelly, Lemkens, Pieter, Compeer, Matthijs G, Janssen, Ben J.A, De Mey, Jo G.R

“…Slow dissociation of endothelin 1 from its endothelin A receptors is responsible for the long-lasting vasoconstrictor effects of the peptide. We showed…”
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Long-lasting physiological antagonism of calcitonin gene-related peptide towards endothelin-1 in rat mesenteric arteries and human coronary arteries by Labruijere, Sieneke, Compeer, Matthijs G., van den Bogaerdt, Antoon J., van den Brink, Antoinette Maassen, De Mey, Jo G.R., Danser, A.H. Jan, Batenburg, Wendy W.

“…Endothelin-1 causes long-lasting contraction via endothelin type A receptor (ETAR) in isolated rat mesenteric arteries (RMA) that cannot be readily terminated…”
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Measuring non‐polyaminated lipocalin‐2 for cardiometabolic risk assessment by Yang, Kangmin, Deng, Han‐Bing, Man, Andy W.C., Song, Erfei, Zhang, Jialiang, Luo, Cuiting, Cheung, Bernard M.Y., Yuen, Kwok‐Yung, Jensen, Pia Søndergaard, Irmukhamedov, Akhmadjon, Elie, Atlanta G.I.M., Vanhoutte, Paul M., Xu, Aimin, De Mey, Jo G.R., Wang, Yu

“…Aims Lipocalin‐2 is a pro‐inflammatory molecule characterized by a highly diversified pattern of expression and structure–functional relationships. In vivo,…”
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Local IGF Bioactivity Associates with High PAPP-A Activity in the Pericardial Cavity of Cardiovascular Disease Patients by Hjortebjerg, Rikke, Rasmussen, Lars Melholt, Gude, Mette Faurholdt, Irmukhamedov, Akhmadjon, Riber, Lars P, Frystyk, Jan, De Mey, Jo G R

“…Abstract Objective Pregnancy-associated plasma protein-A (PAPP-A) has been suggested as a proatherogenic enzyme by its ability to locally increase insulin-like…”
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End O' The Line Revisited: Moving on from nitric oxide to CGRP by De Mey, Jo G.R., Vanhoutte, Paul M.

“…When endothelin-1(ET-1) was discovered it was hailed as the prototypical endothelium-derived contracting factor (EDCF). However, over the years little evidence…”
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Phosphodiesterase 1 regulation is a key mechanism in vascular aging by Bautista Niño, Paula K, Durik, Matej, Danser, A H Jan, de Vries, René, Musterd-Bhaggoe, Usha M, Meima, Marcel E, Kavousi, Maryam, Ghanbari, Mohsen, Hoeijmakers, Jan H, O'Donnell, Christopher J, Franceschini, Nora, Janssen, Ger M J, De Mey, Jo G R, Liu, Yiwen, Shanahan, Catherine M, Franco, Oscar H, Dehghan, Abbas, Roks, Anton J M

“…Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed signalling involves effects of…”
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Uterine Artery Structural and Functional Changes During Pregnancy in Tissue Kallikrein–Deficient Mice by Hilgers, Rob H.P, Bergaya, Sonia, Schiffers, Paul M.H, Meneton, Pierre, Boulanger, Chantal M, Henrion, Daniel, Lévy, Bernard I, De Mey, Jo G.R

“…OBJECTIVE—Tissue kallikrein (TK) participates in acute flow-induced dilatation (FID) of large arteries. We investigated whether TK deficiency blunts FID and…”
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367 ENDOTHELIN RECEPTOR PHARMACOLOGY IN RESISTANCE ARTERIES; CROSSTALK AND CONSEQUENCES FOR DRUG DISCOVERY by Mey, Jo G.R De

“…Anti-endothelinergic drugs may reduce high blood pressure and end-organ damage in view of the vasospastic, pro-inflammatory and oxidative effects of endogenous…”
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ETA -receptor antagonists or allosteric modulators? by De Mey, Jo G.R, Compeer, Matthijs G, Lemkens, Pieter, Meens, Merlijn J.P.M.T

“…The paracrine signaling peptide endothelin-1 (ET1) is involved in cardiovascular diseases, cancer and chronic pain. It acts on class A G-protein-coupled…”
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Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR by Lemkens, Pieter, Spijkers, Leon Ja, Meens, Merlijn J, Nelissen, Jelly, Janssen, Ben, Peters, Stephan Lm, Schiffers, Paul Mh, De Mey, Jo Gr

“…Endothelin 1 (ET-1), a potent vasoconstrictor, pro-mitogenic and pro-inflammatory peptide, may promote development of endothelial dysfunction and arterial…”
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Deletion of endothelial arginase 1 does not improve vasomotor function in diabetic mice by Chennupati, Ramesh, Meens, Merlijn J., Janssen, Ben J., Dijk, Paul, Hakvoort, Theodorus B. M., Lamers, Wouter H., De Mey, Jo G. R., Koehler, S. Eleonore

“…Endothelial arginase 1 was ablated to assess whether this prevents hyperglycemia‐induced endothelial dysfunction by improving arginine availability for nitric…”
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Endothelin-1 and -2: Two amino acids matter by Compeer, Matthijs G., Suylen, Dennis P.L., Hackeng, Tilman M., De Mey, Jo G.R.

“…Endothelin-1 (ET-1) and endothelin-2 (ET-2; Trp6Leu7ET-1) are expressed by different cell types, but are considered to display identical pharmacological…”
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Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1 by Bai, Bo, Man, Andy W.C., Yang, Kangmin, Guo, Yumeng, Xu, Cheng, Tse, Hung-Fat, Han, Weiping, Bloksgaard, Maria, De Mey, Jo G.R., Vanhoutte, Paul M., Xu, Aimin, Wang, Yu

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Dual neural peptidase/endothelin-converting enzyme inhibition improves endothelial function in mesenteric resistance arteries of young spontaneously hypertensive rats by Lemkens, Pieter, Nelissen, Jelly, Meens, Merlijn J.P.M.T, Janssen, Ben J.A, Schiffers, Paul M.H, De Mey, Jo G.R

“…BACKGROUND:Endothelin-1 (ET1) is a potent vasoconstrictor peptide with pro-mitogenic and pro-inflammatory properties and is therefore of interest in the…”
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Smoothelin-B Deficiency Results in Reduced Arterial Contractility, Hypertension, and Cardiac Hypertrophy in Mice by RENSEN, Sander S, NIESSEN, Petra M, DOEVENDANS, Pieter A, HOFKER, Marten H, DE MEY, Jo G. R, VAN EYS, Guillaume J, VAN DEURSEN, Jan M, JANSSEN, Ben J, HEIJMAN, Edwin, HERMELING, Evelien, MEENS, Merlijn, LIE, Natascha, GIJBELS, Marion J, STRIJKERS, Gustav J

“…Smoothelins are actin-binding proteins that are abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. Their…”
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Uterine Artery Remodeling and Reproductive Performance Are Impaired in Endothelial Nitric Oxide Synthase-Deficient Mice by VAN DER HEIJDEN, Olivier W. H, ESSERS, Yvonne P. G, FAZZI, Gregorio, PEETERS, Louis L. H, DE ME, Jo G. R, VAN EYS, Guillaume J. J. M

“…The progressive rise in uterine blood flow during pregnancy is accompanied by outward hypertrophic remodeling of the uterine artery (UA). This process involves…”
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Impaired flow-induced arterial remodeling in DOCA-salt hypertensive rats by Lemkens, Pieter, Nelissen, Jelly, Meens, Merlijn J P M T, Fazzi, Gregorio E, Janssen, Ger J M, Debets, Jacques J M, Janssen, Ben J A, Schiffers, Paul M H, De Mey, Jo G R

“…Arteries from young healthy animals respond to chronic changes in blood flow and blood pressure by structural remodeling. We tested whether the ability to…”
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Matrix Gla Protein Accumulates at the Border of Regions of Calcification and Normal Tissue in the Media of the Arterial Vessel Wall by Spronk, Henri M.H., Soute, Berry A.M., Schurgers, Leon J., Cleutjens, Jack P.M., Thijssen, Henk H.W., De Mey, Jo G.R., Vermeer, Cees

“…Vitamin K-dependent matrix Gla protein (MGP) has been suggested to play a role in the inhibition of soft-tissue calcification. Here we report the expression of…”
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High sodium intake increases blood pressure and alters renal function in intrauterine growth-retarded rats by SANDERS, Marijke W, FAZZI, Gregorio E, JANSSEN, Ger M. J, BLANCO, Carlos E, DE MEY, Jo G. R

“…A suboptimal fetal environment increases the risk to develop cardiovascular disease in the adult. We reported previously that intrauterine stress in response…”
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Prehypertensive Renin-Angiotensin-Aldosterone System Blockade in Spontaneously Hypertensive Rats Ameliorates the Loss of Long-Term Vascular Function by BAUMANN, Marcus, MEGENS, Remco, BARTHOLOME, Roger, DOLFF, Sebastian, van ZANDVOORT, Marc A.J.M., SMITS, Jos F.M., STRUIJKER-BOUDIER, Harry A.J., De MEY, Jo G.R.

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