Search Results - "De Matteis, A"

Phosphatidylinositol-4-phosphate: The Golgi and beyond by De Matteis, Maria A., Wilson, Cathal, D'Angelo, Giovanni

“…Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as…”
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TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway by Scotto Rosato, A., Montefusco, S., Soldati, C., Di Paola, S., Capuozzo, A., Monfregola, J., Polishchuk, E., Amabile, A., Grimm, C., Lombardo, A., De Matteis, M. A., Ballabio, A., Medina, D. L.

“…The lysosomal calcium channel TRPML1, whose mutations cause the lysosomal storage disorder (LSD) mucolipidosis type IV (MLIV), contributes to upregulate…”
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Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina by Tornabene, Patrizia, Trapani, Ivana, Minopoli, Renato, Centrulo, Miriam, Lupo, Mariangela, de Simone, Sonia, Tiberi, Paola, Dell'Aquila, Fabio, Marrocco, Elena, Iodice, Carolina, Iuliano, Antonella, Gesualdo, Carlo, Rossi, Settimio, Giaquinto, Laura, Albert, Silvia, Hoyng, Carel B, Polishchuk, Elena, Cremers, Frans P M, Surace, Enrico M, Simonelli, Francesca, De Matteis, Maria A, Polishchuk, Roman, Auricchio, Alberto

“…Retinal gene therapy with adeno-associated viral (AAV) vectors holds promises for treating inherited and noninherited diseases of the eye. Although clinical…”
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Goserelin Versus Cyclophosphamide, Methotrexate, and Fluorouracil as Adjuvant Therapy in Premenopausal Patients With Node-Positive Breast Cancer: The Zoladex Early Breast Cancer Research Association Study by JONAT, W, KAUFMANN, M, EIERMANN, W, SZAKOLCZAI, I, PALMER, M, SCHUMACHER, M, GEBERTH, M, LISBOA, B, SAUERBREI, W, BLARNEY, R, CUZICK, J, NAMER, M, FOGELMAN, I, DE HAES, J. C, DE MATTEIS, A, STEWART, A

“…Current adjuvant therapies have improved survival for premenopausal patients with breast cancer but may have short-term toxic effects and long-term effects…”
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Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype by Soldati, Chiara, Lopez‐Fabuel, Irene, Wanderlingh, Luca G, Garcia‐Macia, Marina, Monfregola, Jlenia, Esposito, Alessandra, Napolitano, Gennaro, Guevara‐Ferrer, Marta, Scotto Rosato, Anna, Krogsaeter, Einar K, Paquet, Dominik, Grimm, Christian M, Montefusco, Sandro, Braulke, Thomas, Storch, Stephan, Mole, Sara E, De Matteis, Maria A, Ballabio, Andrea, Sampaio, Julio L, McKay, Tristan, Johannes, Ludger, Bolaños, Juan P, Medina, Diego L

“…Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered…”
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Tamoxifen alone versus adjuvant tamoxifen for operable breast cancer of the elderly: long-term results of the phase III randomized controlled multicenter GRETA trial by Mustacchi, G., Ceccherini, R., Milani, S., Pluchinotta, A., De Matteis, A., Maiorino, L., Farris, A., Scanni, A., Sasso, F.

“…Background: To evaluate the efficacy of tamoxifen as primary treatment in women aged over 70 years with operable breast cancer versus surgery followed by…”
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Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein by Strating, Jeroen R.P.M., van der Linden, Lonneke, Albulescu, Lucian, Bigay, Joëlle, Arita, Minetaro, Delang, Leen, Leyssen, Pieter, van der Schaar, Hilde M., Lanke, Kjerstin H.W., Thibaut, Hendrik Jan, Ulferts, Rachel, Drin, Guillaume, Schlinck, Nina, Wubbolts, Richard W., Sever, Navdar, Head, Sarah A., Liu, Jun O., Beachy, Philip A., De Matteis, Maria A., Shair, Matthew D., Olkkonen, Vesa M., Neyts, Johan, van Kuppeveld, Frank J.M.

“…Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this study, we identify ITZ as a broad-spectrum inhibitor of…”
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The association of financial difficulties with clinical outcomes in cancer patients: secondary analysis of 16 academic prospective clinical trials conducted in Italy by Perrone, F., Jommi, C., Di Maio, M., Gimigliano, A., Gridelli, C., Pignata, S., Ciardiello, F., Nuzzo, F., de Matteis, A., Del Mastro, L., Bryce, J., Daniele, G., Morabito, A., Piccirillo, M.C., Rocco, G., Guizzaro, L., Gallo, C.

“…Financial difficulties, measured by the EORTC C30 questionnaire, were associated with worse quality of life and shorter overall survival of cancer patients…”
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Biological Characteristics and Medical Treatment of Breast Cancer in Young Women-A Featured Population: Results from the NORA Study by Pronzato, P., Mustacchi, G., De Matteis, A., Di Costanzo, F., Rulli, E., Floriani, I., Cazzaniga, M. E.

“…Background. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From…”
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Crossbow injuries: A case report with experimental reconstruction study and a systematic review of literature by Maiese, A., Santoro, P., La Russa, R., De Matteis, A., Turillazzi, E., Frati, P., Fineschi, V.

“…In modern times crossbow - a ranged weapon diffused during Middle Ages - is increasing its popularity in recreational hunting and sports; crossbow bolts have a…”
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Death by artery injury: two peculiar cases of sharp force fatality by Santoro, P, De Matteis, A, Volonnino, G, Mezzetti, E, Del Duca, F, Visi, G, Maiese, A

“…As sharp force injury accounts for 10-20% of clinical forensic examinations, forensic pathologists are often asked to investigate deceased victims of stab…”
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Spectrin tethers and mesh in the biosynthetic pathway by De Matteis, M A, Morrow, J S

“…The paradox of how the Golgi and other organelles can sort a continuous flux of protein and lipid but maintain temporal and morphological stability remains…”
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Comparative study between conventional and new methods in defining the cause of death from anaphylactic shock by Costantino, A, Mezzetti, E, De Matteis, A, Volonnino, G, De Simone, S, Fazio, V

“…Anaphylaxis is defined as a rapid systemic reaction that develops in individuals previously exposed to specific allergens. The new exposure causes systemic…”
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Weekly docetaxel versus CMF as adjuvant chemotherapy for older women with early breast cancer: final results of the randomized phase III ELDA trial by Perrone, F., Nuzzo, F., Di Rella, F., Gravina, A., Iodice, G., Labonia, V., Landi, G., Pacilio, C., Rossi, E., De Laurentiis, M., D'Aiuto, M., Botti, G., Forestieri, V., Lauria, R., De Placido, S., Tinessa, V., Daniele, B., Gori, S., Colantuoni, G., Barni, S., Riccardi, F., De Maio, E., Montanino, A., Morabito, A., Daniele, G., Di Maio, M., Piccirillo, M.C., Signoriello, S., Gallo, C., de Matteis, A.

“…Evidence on adjuvant chemotherapy for elderly early breast cancer patients is poor, due to the low number of phase 3 trials. ELDA shows that weekly docetaxel…”
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Post-mortem diagnosis of sepsis: when it's too late by Passaro, G, dell'Aquila, M, De Filippis, A, Baronti, A, Costantino, A, Iannaccone, F, De Matteis, A

“…Post-mortem diagnosis of sepsis is often very difficult to make, especially in the elderly affected by multiple comorbidities. However, clinical evaluation…”
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Abuse and misuse of prescription opioids: is it only an Ameri- can problem? An observational study on an Italian casuistry by Costantino, A, Manetti, A C, Baronti, A, Scatena, A, Visi, G, Mezzetti, E, David, M C, De Matteis, A, Maiese, A

“…Medical use of prescription opioids has steadily increased since the 1990s, particularly in the U.S.A. and Canada, along with abuse of these substances and…”
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Protein–lipid interactions in membrane trafficking at the Golgi complex by De Matteis, M.A., Godi, A.

“…The integrated interplay between proteins and lipids drives many key cellular processes, such as signal transduction, cytoskeleton remodelling and membrane…”
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Bone effect of adjuvant tamoxifen, letrozole or letrozole plus zoledronic acid in early-stage breast cancer: the randomized phase 3 HOBOE study by Nuzzo, F., Gallo, C., Lastoria, S., Di Maio, M., Piccirillo, M.C., Gravina, A., Landi, G., Rossi, E., Pacilio, C., Labonia, V., Di Rella, F., Bartiromo, A., Buonfanti, G., De Feo, G., Esposito, G., D'Aniello, R., Maiolino, P., Signoriello, S., De Maio, E., Tinessa, V., Colantuoni, G., De Laurentiis, M., D'Aiuto, M., Di Bonito, M., Botti, G., Giordano, P., Daniele, G., Morabito, A., Normanno, N., de Matteis, A., Perrone, F.

“…To measure bone mineral density (BMD) reduction produced by letrozole as compared with tamoxifen and the benefit of the addition of zoledronic acid. A phase 3…”
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The Breast Avastin Trial: phase II study of bevacizumab maintenance therapy after induction chemotherapy with docetaxel and capecitabine for the first-line treatment of patients with locally recurrent or metastatic breast cancer by Bisagni, G., Musolino, A., Panebianco, M., De Matteis, A., Nuzzo, F., Ardizzoni, A., Gori, S., Gamucci, T., Passalacqua, R., Gnoni, R., Moretti, G., Boni, C.

“…Background Therapeutic approach for patients with metastatic breast cancer (MBC) is still controversial. This study was conducted to assess the efficacy and…”
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Breast cancer in elderly women: a different reality? Results from the NORA study by Mustacchi, G, Cazzaniga, ME, Pronzato, P, De Matteis, A, Di Costanzo, F, Floriani, I

“…Background: The incidence of breast cancer increases with age, and the disease affects many older women; however, attitudes about prevention and treatment of…”
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