Search Results - "De Maio, Antonia"

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model by Lasagna-Reeves, Cristian A., de Haro, Maria, Hao, Shuang, Park, Jeehye, Rousseaux, Maxime W.C., Al-Ramahi, Ismael, Jafar-Nejad, Paymaan, Vilanova-Velez, Luis, See, Lauren, De Maio, Antonia, Nitschke, Larissa, Wu, Zhenyu, Troncoso, Juan C., Westbrook, Thomas F., Tang, Jianrong, Botas, Juan, Zoghbi, Huda Y.

“…Many neurodegenerative proteinopathies share a common pathogenic mechanism: the abnormal accumulation of disease-related proteins. As growing evidence…”
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Pumilio1 Haploinsufficiency Leads to SCA1-like Neurodegeneration by Increasing Wild-Type Ataxin1 Levels by Gennarino, Vincenzo A., Singh, Ravi K., White, Joshua J., De Maio, Antonia, Han, Kihoon, Kim, Ji-Yoen, Jafar-Nejad, Paymaan, di Ronza, Alberto, Kang, Hyojin, Sayegh, Layal S., Cooper, Thomas A., Orr, Harry T., Sillitoe, Roy V., Zoghbi, Huda Y.

“…Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative proteinopathy, in which a mutant protein (in this case, ATAXIN1) accumulates in…”
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TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau by Rousseaux, Maxime Wc, de Haro, Maria, Lasagna-Reeves, Cristian A, De Maio, Antonia, Park, Jeehye, Jafar-Nejad, Paymaan, Al-Ramahi, Ismael, Sharma, Ajay, See, Lauren, Lu, Nan, Vilanova-Velez, Luis, Klisch, Tiemo J, Westbrook, Thomas F, Troncoso, Juan C, Botas, Juan, Zoghbi, Huda Y

“…Several neurodegenerative diseases are driven by the toxic gain-of-function of specific proteins within the brain. Elevated levels of alpha-synuclein (α-Syn)…”
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Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models by Tan, Qiumin, Yalamanchili, Hari Krishna, Park, Jeehye, De Maio, Antonia, Lu, Hsiang-Chih, Wan, Ying-Wooi, White, Joshua J, Bondar, Vitaliy V, Sayegh, Layal S, Liu, Xiuyun, Gao, Yan, Sillitoe, Roy V, Orr, Harry T, Liu, Zhandong, Zoghbi, Huda Y

“…Splicing regulation is an important step of post-transcriptional gene regulation. It is a highly dynamic process orchestrated by RNA-binding proteins (RBPs)…”
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RBM17 Interacts with U2SURP and CHERP to Regulate Expression and Splicing of RNA-Processing Proteins by De Maio, Antonia, Yalamanchili, Hari Krishna, Adamski, Carolyn J., Gennarino, Vincenzo A., Liu, Zhandong, Qin, Jun, Jung, Sung Y., Richman, Ronald, Orr, Harry, Zoghbi, Huda Y.

“…RNA splicing entails the coordinated interaction of more than 150 proteins in the spliceosome, one of the most complex of the cell’s molecular machines. We…”
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COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression by Alfano, Christian, Viola, Luigi, Heng, Julian Ik-Tsen, Pirozzi, Marinella, Clarkson, Michael, Flore, Gemma, De Maio, Antonia, Schedl, Andreas, Guillemot, François, Studer, Michèle

“…During corticogenesis, late-born callosal projection neurons (CPNs) acquire their laminar position through glia-guided radial migration and then undergo final…”
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Mecp2 Deletion from Cholinergic Neurons Selectively Impairs Recognition Memory and Disrupts Cholinergic Modulation of the Perirhinal Cortex by Ballinger, Elizabeth C, Schaaf, Christian P, Patel, Akash J, de Maio, Antonia, Tao, Huifang, Talmage, David A, Zoghbi, Huda Y, Role, Lorna W

“…Rett Syndrome is a neurological disorder caused by mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) and characterized by severe intellectual…”
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