Search Results - "De Los Frailes, Maite"

Identification of novel isoform-selective inhibitors within class I histone deacetylases by Hu, Erding, Dul, Edward, Sung, Chiu-Mei, Chen, Zunxuan, Kirkpatrick, Robert, Zhang, Gui-Feng, Johanson, Kyung, Liu, Ronggang, Lago, Amparo, Hofmann, Glenn, Macarron, Ricardo, de los Frailes, Maite, Perez, Paloma, Krawiec, John, Winkler, James, Jaye, Michael

“…Histone deacetylases (HDACs) represent an expanding family of protein modifying-enzymes that play important roles in cell proliferation, chromosome remodeling,…”
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Discovery of Substituted Maleimides as Liver X Receptor Agonists and Determination of a Ligand-Bound Crystal Structure by Jaye, Michael C, Krawiec, John A, Campobasso, Nino, Smallwood, Angela, Qiu, Chunyan, Lu, Quinn, Kerrigan, John J, De Los Frailes Alvaro, Maite, Laffitte, Bryan, Liu, Wu-Schyong, Marino, Joseph P, Meyer, Craig R, Nichols, Jason A, Parks, Derek J, Perez, Paloma, Sarov-Blat, Lea, Seepersaud, Sheila D, Steplewski, Klaudia M, Thompson, Scott K, Wang, Ping, Watson, Mike A, Webb, Christine L, Haigh, David, Caravella, Justin A, Macphee, Colin H, Willson, Timothy M, Collins, Jon L

“…Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1…”
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Discovery of Novel Inhibitors of the Tautomerase Activity of Macrophage Migration Inhibitory Factor (MIF) by Zapatero, Maria Cleofé, Pérez, Paloma, Vázquez, María Jesús, Colmenarejo, Gonzalo, de Los Frailes, Maite, Ramón, Fernando

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine associated with multiple diseases, including neurodegenerative disorders. With the…”
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Discovery of Enhancers of the Secretion of Leukemia Inhibitory Factor for the Treatment of Multiple Sclerosis by Vela, Laura, Caballero, Iván, Fang, Leiping, Liu, Qin, Ramón, Fernando, Díez, Emilio, de Los Frailes, Maite

“…Multiple sclerosis (MS) is an autoimmune neurodegenerative disease that involves activation of T cells, microglia, and astrocytes. There is a clear unmet…”
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Screening technologies for G protein-coupled receptors: from HTS to uHTS by De los Frailes, Maite, Diez, Emilio

“…The discovery of drugs for G protein-coupled receptors (GPCRs) has traditionally been very successful, even before the structural nature of these molecular…”
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Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists by Evans, Karen A, Budzik, Brian W, Ross, Sean A, Wisnoski, David D, Jin, Jian, Rivero, Ralph A, Vimal, Mythily, Szewczyk, George R, Jayawickreme, Channa, Moncol, David L, Rimele, Thomas J, Armour, Susan L, Weaver, Susan P, Griffin, Robert J, Tadepalli, Sarva M, Jeune, Michael R, Shearer, Todd W, Chen, Zibin B, Chen, Lihong, Anderson, Donald L, Becherer, J. David, De Los Frailes, Maite, Colilla, Francisco Javier

“…A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent small molecule agonists of the human TGR5…”
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The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2 by D’Alessandro, Pier L., Corti, Corrado, Roth, Adelheid, Ugolini, Annarosa, Sava, Anna, Montanari, Dino, Bianchi, Federica, Garland, Stephen L., Powney, Ben, Koppe, Emma L., Rocheville, Magalie, Osborne, Greg, Perez, Paloma, de la Fuente, Jesús, De Los Frailes, Maite, Smith, Paul W., Branch, Clive, Nash, David, Watson, Stephen P.

“…The optimisation of an HTS hit series ( 1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 positive modulators…”
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Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification by Heightman, Tom D., Scott, Jackie S., Longley, Mark, Bordas, Vincent, Dean, David K., Elliott, Richard, Hutley, Gail, Witherington, Jason, Abberley, Lee, Passingham, Barry, Berlanga, Manuela, de los Frailes, Maite, Wise, Alan, Powney, Ben, Muir, Alison, McKay, Fiona, Butler, Sharon, Winborn, Kim, Gardner, Christopher, Darton, Jill, Campbell, Colin, Sanger, Gareth

“…A series of indolines showing potent in vitro ghrelin receptor agonism and acceleration of gastric emptying in rats is described. High throughput screening…”
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