Search Results - "De Leonardis, Giampiero"
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Autotaxin-Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic Implications
Published in International journal of molecular sciences (15-07-2024)“…Autotaxin (ATX) is a member of the ectonucleotide pyrophosphate/phosphodiesterase ( ) family; it is encoded by the gene. ATX is a secreted glycoprotein and…”
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Differential Tissue Fatty Acids Profiling between Colorectal Cancer Patients with and without Synchronous Metastasis
Published in International journal of molecular sciences (23-03-2018)“…The early detection of colorectal cancer and determination of its metastatic potential are important factors to set up more efficacious therapeutic strategies…”
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Aerobic Physical Activity and a Low Glycemic Diet Reduce the AA/EPA Ratio in Red Blood Cell Membranes of Patients with NAFLD
Published in Nutrients (13-09-2018)“…Omega-6 Polyunsaturated Fatty Acids (PUFAs), through the eicosanoids derived from arachidonic acid (AA), are able to modulate the inflammatory processes,…”
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Corrigendum: Variations in circulating levels of angiopoietin-2 over time are predictive of ramucirumab-paclitaxel therapy outcome in advanced gastric cancer: results of prospective study
Published in Frontiers in oncology (14-04-2023)“…[This corrects the article DOI: 10.3389/fonc.2022.862116.]…”
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Variations in Circulating Levels of Angiopoietin-2 Over Time Are Predictive of Ramucirumab-Paclitaxel Therapy Outcome in Advanced Gastric Cancer: Results of Prospective Study
Published in Frontiers in oncology (06-04-2022)“…The combination of paclitaxel and ramucirumab is the second-line therapy of choice in the treatment of advanced gastric cancer. To date, no biomarkers are…”
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The multiple combination of Paclitaxel, Ramucirumab and Elacridar reverses the paclitaxel-mediated resistance in gastric cancer cell lines
Published in Frontiers in oncology (16-02-2023)“…Paclitaxel (PTX) interferes with microtubule architecture by binding to β-tubulin, thereby blocking progression at the G2/M phase and inducing apoptosis. This…”
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VEGFA Status as a Predictive Marker of Therapy Outcome in Metastatic Gastric Cancer Patients Following Ramucirumab-Based Treatment
Published in Biomedicines (07-10-2023)“…Metastatic gastric cancer (mGC) often has a poor prognosis and may benefit from a few targeted therapies. Ramucirumab-based anti-angiogenic therapy targeting…”
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Nutrition and lipidomic profile in colorectal cancers
Published in Acta bio-medica : Atenei Parmensis (17-12-2018)“…Adherence to a healthy diet has been reported to be essential for the primary prevention of colorectal cancer, through a reduction of tissue inflammation, a…”
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Tissue Fatty Acid Profile is Differently Modulated from Olive Oil and Omega-3 Polyunsaturated Fatty Acids in ApcMin/+ Mice
Published in Endocrine, metabolic & immune disorders drug targets (16-11-2017)“…Fatty acid profile can be considered an appropriate biomarker for investigating the relations between the patterns of fatty acid metabolism and specific…”
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Women in LOVe: Lacto-Ovo-Vegetarian Diet Rich in Omega-3 Improves Vasomotor Symptoms in Postmenopausal Women. An Exploratory Randomized Controlled Trial
Published in Endocrine, metabolic & immune disorders drug targets (01-01-2019)“…In the postmenopausal period, most women suffer vasomotor symptoms (VMS). It is well-known that VMS can worsen the quality of life. Diet seems to play a…”
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Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models
Published in European journal of medicinal chemistry (05-12-2023)“…Formyl peptide receptor-1 (FPR1) is a G protein-coupled chemoattractant receptor that plays a crucial role in the trafficking of leukocytes into the sites of…”
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High levels of autotaxin and lysophosphatidic acid predict poor outcome in treatment of resectable gastric carcinoma
Published in European journal of cancer (1990) (01-12-2024)“…Although early-stage gastric cancer is a candidate for curative surgical resection, the absence of specific early symptoms results in a late diagnosis and…”
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Targeting Angiogenesis in the Era of Biliary Tract Cancer Immunotherapy: Biological Rationale, Clinical Implications, and Future Research Avenues
Published in Cancers (19-04-2023)“…Although biliary tract cancers are traditionally considered rare in Western countries, their incidence and mortality rates are rising worldwide. A better…”
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Significant decrease of saturation index in erythrocytes membrane from subjects with non-alcoholic fatty liver disease (NAFLD)
Published in Lipids in health and disease (23-08-2017)“…The lipidomic profiling of erythrocyte membranes is expected to provide a peculiar scenario at molecular level of metabolic and nutritional pathways which may…”
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Fatty liver and mortality: a cohort population study in South Italy
Published in BMJ open (01-06-2019)“…ObjectiveAlcoholic fatty liver (AFLD) and non-alcoholic fatty liver (NAFLD) are two common conditions. However, if they can increase the risk of death is…”
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