Search Results - "De Leon, M."

Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues by Zhang, Shengping, De Leon Rodriguez, Luis M, Li, Freda F, Brimble, Margaret A

“…Peptide and protein selective modification at tyrosine residues has become an exploding field of research as tyrosine constitutes a robust alternative to…”
Get full text

Guidelines for the clinical management of familial adenomatous polyposis (FAP) by Vasen, H F A, Möslein, G, Alonso, A, Aretz, S, Bernstein, I, Bertario, L, Blanco, I, Bülow, S, Burn, J, Capella, G, Colas, C, Engel, C, Frayling, I, Friedl, W, Hes, F J, Hodgson, S, Järvinen, H, Mecklin, J-P, Møller, P, Myrhøi, T, Nagengast, F M, Parc, Y, Phillips, R, Clark, S K, de Leon, M Ponz, Renkonen-Sinisalo, L, Sampson, J R, Stormorken, A, Tejpar, S, Thomas, H J W, Wijnen, J

“…Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is…”
Get more information

Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease by MOSCONI, L, MISTUR, R, SWITALSKI, R, BRYS, M, GLODZIK, L, RICH, K, PIRRAGLIA, E, TSUI, W, DE SANTI, S, DE LEON, M. J

“…At cross-section, cognitively normal individuals (NL) with a maternal history of late-onset Alzheimer disease (AD) have reduced glucose metabolism (CMRglc) on…”
Get full text

Sudden death related to sexual activity: A multicenter study based on forensic autopsies (2010-2021) by Lopez-Garcia, P, de Leon, M S Sanchez, Hernandez-Guerra, A I, Fernandez-Liste, A, Lucena, J, Morentin, B

“…To investigate the epidemiological characteristics, clinic-pathological findings and recent use of substances of abuse and prescribed drugs in sexual…”
Get full text

Chemical Synthesis of Bioactive Naturally Derived Cyclic Peptides Containing Ene‐Like Rigidifying Motifs by De Leon Rodriguez, Luis M., Williams, Elyse T., Brimble, Margaret A.

“…The development of synthetic methods to prepare conformationally constrained peptides and peptide–polyketide hybrids remain an important chemical challenge. It…”
Get full text

Hippocampal and entorhinal atrophy in mild cognitive impairment : Prediction of Alzheimer disease by DEVANAND, D. P, PRADHABAN, G, STERN, Y, TABERT, M. H, DE LEON, M. J, LIU, X, KHANDJI, A, DE SANTI, S, SEGAL, S, RUSINEK, H, PELTON, G. H, HONIG, L. S, MAYEUX, R

“…To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease…”
Get full text

A systematic review of worldwide data on tinea capitis: analysis of the last 20 years by Rodríguez‐Cerdeira, C., Martínez‐Herrera, E., Szepietowski, J.C., Pinto‐Almazán, R., Frías‐De‐León, M.G., Espinosa‐Hernández, V.M., Chávez‐Gutiérrez, E., García‐Salazar, E., Vega‐Sánchez, D.C., Arenas, R., Hay, R., Saunte, D.M.

“…Dermatophyte infections are the most common fungal infections in humans; among them, tinea capitis (TC) – the most contagious fungal infection – is caused by…”
Get full text

Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals by Berti, V, Murray, J, Davies, M, Spector, N, Tsui, W. H, Li, Y, Williams, S, Pirraglia, E, Vallabhajosula, S, McHugh, P, Pupi, A, de Leon, M. J, Mosconi, Lisa

“…OBJECTIVES: Epidemiological evidence linking diet, one of the most important modifiable lifestyle factors, and risk of Alzheimer’s disease (AD) is rapidly…”
Get full text

Prospecting the applications and discovery of peptide hydrogels in food by De Leon Rodriguez, Luis M., Hemar, Yacine

“…The interest in peptide hydrogels of natural origin has dramatically increased given the potential applications in several fields -e.g. biomedicine and…”
Get full text

Reduced hippocampal metabolism in MCI and AD : Automated FDG-PET image analysis by MOSCONI, L, TSUI, W.-H, DE SANTI, S, LI, J, RUSINEK, H, CONVIT, A, LI, Y, BOPPANA, Madhu, DE LEON, M. J

“…To facilitate image analysis, most recent 2-[18F]fluoro-2-deoxy-d-glucose PET (FDG-PET) studies of glucose metabolism (MRglc) have used automated voxel-based…”
Get full text

Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment by Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L.‐O., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., Arai, H., Basun, H., Blennow, K., De Leon, M., DeCarli, C., Erkinjuntti, T., Giacobini, E., Graff, C., Hardy, J., Jack, C., Jorm, A., Ritchie, K., Van Duijn, C., Visser, P., Petersen, R.C.

“… The First Key Symposium was held in Stockholm, Sweden, 2–5 September 2003. The aim of the symposium was to integrate clinical and epidemiological…”
Get full text

Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors by Ferrer, I, Verdugo-Sivianes, E M, Castilla, M A, Melendez, R, Marin, J J, Muñoz-Galvan, S, Lopez-Guerra, J L, Vieites, B, Ortiz-Gordillo, M J, De León, J M, Praena-Fernandez, J M, Perez, M, Palacios, J, Carnero, A

“…The spinophilin (Spn, PPP1R9B) gene is located at 17q21.33, a region frequently associated with microsatellite instability and loss of heterozygosity,…”
Get full text

Metabolomics uncovers dietary omega-3 fatty acid-derived metabolites implicated in anti-nociceptive responses after experimental spinal cord injury by Figueroa, J.D, Cordero, K, Serrano-Illan, M, Almeyda, A, Baldeosingh, K, Almaguel, F.G, De Leon, M

“…Graphical abstract…”
Get full text

Synthesis and bioactivity of antitubercular peptides and peptidomimetics: an update by De Leon Rodriguez, Luis M, Kaur, Harveen, Brimble, Margaret A

“…Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), an infection that has been declared a global public health emergency by the World…”
Get more information

Synthesis of Natural Cyclopentapeptides Isolated from Dianthus chinensis by Zhang, Shengping, Amso, Zaid, De Leon Rodriguez, Luis M, Kaur, Harveen, Brimble, Margaret A

“…The first syntheses of the naturally occurring cyclic peptides dianthin I (1), pseudostellarin A (2), and heterophyllin J (3) are described. The linear…”
Get full text

Transient Flare of Ulcerative Colitis After Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection by De Leon, Lauren M, Watson, James B, Kelly, Colleen R

“…Clostridium difficile infection (CDI) is a common cause of infectious diarrhea and is usually treated with metronidazole or vancomycin. CDI recurs in 15%–30%…”
Get full text

Preventing surgical site infection using operating room bundle of care in patients undergoing elective exploratory laparotomy cholecystectomy surgery by Magat, Erika Leslie R, De Leon, Josephine M

“…Surgical procedures manifest immense risks to patients. One of the adverse events that healthcare professionals see as a threat to the patient’s health is the…”
Get full text

Stress-constrained topology optimization for compliant mechanism design by De Leon, Daniel M., Alexandersen, Joe, O. Fonseca, Jun S., Sigmund, Ole

“…This article presents an application of stress-constrained topology optimization to compliant mechanism design. An output displacement maximization formulation…”
Get full text

Track analysis, simulation, and field survey of the 2013 Typhoon Haiyan storm surge by Takagi, H., Esteban, M., Shibayama, T., Mikami, T., Matsumaru, R., De Leon, M., Thao, N.D., Oyama, T., Nakamura, R.

“…The authors have examined the characteristics of Typhoon Haiyan (Yolanda), which made landfall on the coast of the Philippines on November 2013, generating a…”
Get full text

Total Synthesis and Conformational Study of Callyaerin A: Anti‐Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z)‐2,3‐ Diaminoacrylamide Moiety by Zhang, Shengping, De Leon Rodriguez, Luis M., Leung, Ivanhoe K. H., Cook, Gregory M., Harris, Paul W. R., Brimble, Margaret A.

“…The first synthesis of the anti‐TB cyclic peptide callyaerin A (1), containing a rare (Z)‐2,3‐diaminoacrylamide bridging motif, is reported…”
Get full text