Search Results - "De Leij, Lou F. M. H."

Kinetics of US28 Gene Expression during Active Human Cytomegalovirus Infection in Lung-Transplant Recipients by Boomker, Jasper M., Verschuuren, Erik A. M., Brinker, Marja G. L., de Leij, Lou F. M. H., The, T. Hauw, Harmsen, Martin C.

“…Targeting viral proteins early during infection may limit exacerbation of human cytomegalovirus infection. The viral chemokine-receptor homologue US28…”
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In vivo characteristics of cationic liposomes as delivery vectors for gene therapy by AUDOUY, Sandrine A. L, DE LEIJ, Lou F. M. H, HOEKSTRA, Dick, MOLEMA, Grietje

“…After a decade of clinical trials, gene therapy seems to have found its place between excessive ambitions and feasible aims, with encouraging results obtained…”
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Epithelial Cell Adhesion Molecule: More than a Carcinoma Marker and Adhesion Molecule by Trzpis, Monika, McLaughlin, Pamela M.J, de Leij, Lou M.F.H, Harmsen, Martin C

“…The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of approximately 40 kd that was originally identified as a marker for carcinoma,…”
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EpCAM in carcinogenesis: the good, the bad or the ugly by van der Gun, Bernardina T.F., Melchers, Lieuwe J., Ruiters, Marcel H.J., de Leij, Lou F.M.H., McLaughlin, Pamela M.J., Rots, Marianne G.

“…The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly expressed on most carcinomas and therefore of potential use as a…”
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Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells by Bremer, Edwin, de Bruyn, Marco, Samplonius, Douwe F., Bijma, Theo, ten Cate, Bram, de Leij, Lou F. M. H., Helfrich, Wijnand

“…Previously, we have shown that epidermal growth factor receptor (EGFR)-selective delivery of soluble tumor necrosis factor-related apoptosis-inducing ligand…”
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Fas Receptor Clustering and Involvement of the Death Receptor Pathway in Rituximab-Mediated Apoptosis with Concomitant Sensitization of Lymphoma B Cells to Fas-Induced Apoptosis by Stel, Alja J, ten Cate, Bram, Jacobs, Susan, Kok, Jan Willem, Spierings, Diana C. J, Dondorff, Monica, Helfrich, Wijnand, Kluin-Nelemans, Hanneke C, de Leij, Lou F. M. H, Withoff, Sebo, Kroesen, Bart Jan

“…Ab binding to CD20 has been shown to induce apoptosis in B cells. In this study, we demonstrate that rituximab sensitizes lymphoma B cells to Fas-induced…”
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Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study by TAMMINGA, Wim J, WEMER, Johan, OOSTERHUIS, Berend, DE BOER, Anthonius, VRANCKX, Stan, DRENTH, Ben F. H, DE ZEEUW, Rokus A, DE LEIJ, Lou F. M. H, JONKMAN, Jan H. G

“…The aim of the current retrospective study was to assess the influence of polymorphic drug metabolism as assessed by genotyping, on the on the utilisation of…”
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CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia by Bremer, Edwin, Cate, Bram ten, Samplonius, Douwe F., de Leij, Lou F.M.H., Helfrich, Wijnand

“…Agonistic anti-Fas antibodies and multimeric recombinant Fas ligand (FasL) preparations show high tumoricidal activity against leukemic cells, but are…”
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Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2 by VAN DER GUN, Bernardina T. F, MONAMI, Amélie, MCLAUGHLIN, Pamela M. J, LAARMANN, Sven, RASKO, Tamas, SLASKA-KISS, Krystyna, WEINHOLD, Elmar, WASSERKORT, Reinhold, DE LEIJ, Lou F. M. H, RUITERS, Marcel H. J, KISS, Antal

“…Cationic liposomal compounds are widely used to introduce DNA and siRNA into viable cells, but none of these compounds are also capable of introducing…”
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Biodistribution Studies of Epithelial Cell Adhesion Molecule (EpCAM)-Directed Monoclonal Antibodies in the EpCAM-Transgenic Mouse Tumor Model by Kosterink, Jos G. W, McLaughlin, Pamela M. J, Lub-de Hooge, Marjolijn N, Hendrikse, Harry H, van Zanten, Jacoba, van Garderen, Evert, Harmsen, Martin C, de Leij, Lou F. M. H

“…The human pancarcinoma-associated epithelial cell adhesion molecule (EpCAM) (EGP-2, CO17-1A) is a well-known target for carcinoma-directed immunotherapy…”
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Persistent downregulation of the pancarcinoma‐associated epithelial cell adhesion molecule via active intranuclear methylation by van der Gun, Bernardina T.F., Wasserkort, Reinhold, Monami, Amélie, Jeltsch, Albert, Raskó, Tamás, Ślaska‐Kiss, Krystyna, Cortese, Rene, Rots, Marianne G., de Leij, Lou F.M.H., Ruiters, Marcel H.J., Kiss, Antal, Weinhold, Elmar, McLaughlin, Pamela M.J.

“…The epithelial cell adhesion molecule (EpCAM) is expressed at high levels on the surface of most carcinoma cells. SiRNA silencing of EpCAM expression leads to…”
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The Role of B Cell-Mediated T Cell Costimulation in the Efficacy of the T Cell Retargeting Bispecific Antibody BIS20x3 by Stel, Alja J, Kroesen, Bart-Jan, Jacobs, Susan, Groen, Herman, de Leij, Lou F. M. H, Kluin-Nelemans, Hanneke C, Withoff, Sebo

“…In this study, we investigated the role of the naturally occurring B cell-mediated T cell costimulation in the antitumor efficacy of the bispecific Ab BIS20x3…”
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Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer by Kok, Klaas, Osinga, Jan, Carritt, Ben, Davis, Mary B, van der Hout, Annemarie H, van der Veen, Anneke Y, Landsvater, Rudy M, de Leij, Lou F. M. H, Berendsen, Henk H, Postmus, Pieter E, Poppema, Sibrand, Buys, Charles H. C. M

“…In childhood malignancies such as retinoblastoma and Wilms tumour, of which both familial and sporadic forms exist, recessive mutations of presumed…”
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Simultaneous Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling and Enhanced Activation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Receptor-mediated Apoptosis Induction by an scFv:sTRAIL Fusion Protein with Specificity for Human EGFR by Bremer, Edwin, Samplonius, Douwe F., van Genne, Linda, Dijkstra, Marike H., Kroesen, Bart Jan, de Leij, Lou F.M.H., Helfrich, Wijnand

“…Epidermal growth factor receptor (EGFR) signaling inhibition by monoclonal antibodies and EGFR-specific tyrosine kinase inhibitors has shown clinical efficacy…”
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Specific immune responses against airway epithelial cells in a transgenic mouse-trachea transplantation model for obliterative airway disease by NING QU, DE BRAN, Aalzen, HARMSEN, Martin C, KROESE, Frans G. M, DE LEIJ, Lou F. M. H, PROP, Jochum

“…Immune injury to airway epithelium is suggested to play a central role in the pathogenesis of obliterative bronchiolitis (OB) after clinical lung…”
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BcR-induced Apoptosis Involves Differential Regulation of C16 and C24-Ceramide Formation and Sphingolipid-dependent Activation of the Proteasome by Kroesen, Bart-Jan, Jacobs, Susan, Pettus, Benjamin J., Sietsma, Hannie, Kok, Jan Willem, Hannun, Yusuf A., de Leij, Lou F.M.H.

“…In this study, we describe an ordered formation of long- and very long-chain ceramide species in relation to the progression of B-cell receptor (BcR)…”
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EpCAM in morphogenesis by Trzpis, Monika, Bremer, Edwin, McLaughlin, Pamela M J, de Leij, Lou F M H, Harmsen, Martin C

“…Embryonic development is one of the most complex biological phenomena that involves the appropriate expression and synchronized interactions of a plethora of…”
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Distribution patterns of the membrane glycoprotein CD44 during the foreign-body reaction to a degradable biomaterial in rats and mice by Bonnema, Harmke, Popa, Eliane R, van Timmeren, Mirjan M., van Wachem, Pauline B., de Leij, Lou F. M. H., van Luyn, Marja J. A.

“…Although biomaterials have been used in the clinical setting for a long time, little is known of the molecular mechanisms underlying the foreign‐body reaction…”
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Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra‐individual reproducibility and occurrence of adverse events by Tamminga, Wim J., Wemer, Johan, Oosterhuis, Berend, Wieling, Jaap, Touw, Daan J., De Zeeuw, Rokus A., De Leij, Lou F. M. H., Jonkman, Jan H. G.

“…Aims  To further evaluate mephenytoin as a probe for CYP2C19 phenotyping. Methods  Healthy subjects (n = 2638) were phenotyped using the urinary…”
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The human cytomegalovirus-encoded receptor US28 increases the activity of the major immediate-early promoter/enhancer by Boomker, Jasper M., The, T. Hauw, de Leij, Lou F.M.H., Harmsen, Martin C.

“…The activation of the major immediate-early promoter (MIEP) is a key event in the cytomegalovirus replication cycle and is dependent on cellular transcription…”
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