Search Results - "De Leenheer, Evy"

Adoptive Transfer of Autoimmune Diabetes Using Immunodeficient Nonobese Diabetic (NOD) Mice by De Leenheer, Evy, Wong, F Susan

“…Studying Type 1 Diabetes (T1D) in the nonobese diabetic (NOD) mouse model can be cumbersome as onset of disease does not usually occur naturally prior to the…”
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Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide by Motozono, Chihiro, Pearson, James A., De Leenheer, Evy, Rizkallah, Pierre J., Beck, Konrad, Trimby, Andrew, Sewell, Andrew K., Wong, F. Susan, Cole, David K.

“…The non-obese diabetic mouse model of type 1 diabetes continues to be an important tool for delineating the role of T-cell-mediated destruction of pancreatic…”
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Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes by Thayer, Terri C, Pearson, James A, De Leenheer, Evy, Hanna, Stephanie J, Boldison, Joanne, Davies, Joanne, Tsui, Adrian, Ahmed, Sartaj, Easton, Peter, Siew, Lai Khai, Wen, Li, Wong, F Susan

“…Low-avidity autoreactive CD8 T cells (CTLs) escape from thymic negative selection, and peripheral tolerance mechanisms are essential for their regulation. We…”
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Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma by Buckle, Clive Henry, De Leenheer, Evy, Lawson, Michelle Anne, Yong, Kwee, Rabin, Neil, Perry, Mark, Vanderkerken, Karen, Croucher, Peter Ian

“…Patients with multiple myeloma commonly develop focal osteolytic bone disease, as well as generalised osteoporosis. The mechanisms underlying the development…”
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A novel redox method for rapid production of functional bi-specific antibodies for use in early pilot studies by Carlring, Jennifer, De Leenheer, Evy, Heath, Andrew William

“…We demonstrate here a rapid alternative method for the production of functional bi-specific antibodies using the mild reducing agent 2-mercaptoethanesulfonic…”
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Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model by Menu, Eline, De Leenheer, Evy, De Raeve, Hendrik, Coulton, Les, Imanishi, Takeshi, Miyashita, Kazuyuki, Van Valckenborgh, Els, Van Riet, Ivan, Van Camp, Ben, Horuk, Richard, Croucher, Peter, Vanderkerken, Karin

“…Multiple myeloma (MM) is a plasma cell malignancy, characterized by the localization of the MM cells in the bone marrow (BM), where they proliferate and induce…”
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Targeting the IGF‐1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: Beneficial effects on tumor growth, angiogenesis, bone disease and survival by Menu, Eline, Jernberg‐Wiklund, Helena, De Raeve, Hendrik, De Leenheer, Evy, Coulton, Les, Gallagher, Orla, Van Valckenborgh, Els, Larsson, Olle, Axelson, Magnus, Nilsson, Kenneth, Van Camp, Ben, Croucher, Peter, Vanderkerken, Karin

“…During the last decade, a central role for insulin‐like growth factor 1 (IGF‐1) in the pathophysiology of multiple myeloma (MM) has been well established…”
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Multifunctional Role of Matrix Metalloproteinases in Multiple Myeloma by Van Valckenborgh, Els, Croucher, Peter I., De Raeve, Hendrik, Carron, Chris, De Leenheer, Evy, Blacher, Sylvia, Devy, Laetitia, Noël, Agnès, De Bruyne, Elke, Asosingh, Kewal, Van Riet, Ivan, Van Camp, Ben, Vanderkerken, Karin

“…Matrix metalloproteinases (MMPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the…”
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B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model by Da Rosa, Larissa C., Boldison, Joanne, De Leenheer, Evy, Davies, Joanne, Wen, Li, Wong, F. Susan

“…Aims/hypothesis Type 1 diabetes is a T cell-mediated autoimmune disease characterised by the destruction of beta cells in the islets of Langerhans, resulting…”
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Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes by Fishman, Sigal, Lewis, Mark D., Siew, L. Khai, De Leenheer, Evy, Kakabadse, Dimitri, Davies, Joanne, Ziv, Doron, Margalit, Alon, Karin, Nathan, Gross, Gideon, Wong, F. Susan

“…Chimeric major histocompatibility complex (MHC) molecules supplemented with T cell receptor (TCR) signaling motifs function as activation receptors and can…”
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A reproducible method for the expansion of mouse CD8+ T lymphocytes by Lewis, Mark D., de Leenheer, Evy, Fishman, Sigal, Siew, Lai Khai, Gross, Gideon, Wong, F. Susan

“…Murine adoptive CD8+ T-cell immunotherapy studies require the generation of large numbers of high viability CD8+ cells. Here we report a tissue culture…”
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Conjugation of lymphoma idiotype to CD40 antibody enhances lymphoma vaccine immunogenicity and antitumor effects in mice by Carlring, Jennifer, Szabo, Marika J., Dickinson, Robert, De Leenheer, Evy, Heath, Andrew W.

“…Personalized immunotherapy of lymphoma based on tumor idiotype (Id) has shown anti-idiotype humoral immune responses in 40%-50% and cellular immune responses…”
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Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells by Pearson, James A, Thayer, Terri C, McLaren, James E, Ladell, Kristin, De Leenheer, Evy, Phillips, Amy, Davies, Joanne, Kakabadse, Dimitri, Miners, Kelly, Morgan, Peter, Wen, Li, Price, David A, Wong, F Susan

“…NOD mice, a model strain for human type 1 diabetes, express proinsulin (PI) in the thymus. However, insulin-reactive T cells escape negative selection, and…”
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Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma by VANDERKERKEN, Karin, DE LEENHEER, Evy, SHIPMAN, Claire, ASOSINGH, Kewal, WILLEMS, Angelo, VAN CAMP, Ben, CROUCHER, Peter

“…The aim of the present study was to determine whether modifying the local bone environment with osteoprotegerin (OPG), the soluble decoy receptor for receptor…”
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Multifunctional Role of Matrix Metalloproteinases in Multiple Myeloma: A Study in the 5T2MM Mouse Model by Van Valckenborgh, Els, Croucher, Peter I, De Raeve, Hendrik, Carron, Chris, De Leenheer, Evy, Blacher, Sylvia, Devy, Laetitia, Noel, Agnes, De Bruyne, Elke, Asosingh, Kewal, Van Riet, Ivan, Van Camp, Ben, Vanderkerken, Karin

“…Matrix metalloproteinases (MMPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the…”
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Evidence of a role for RANKL in the development of myeloma bone disease by De Leenheer, Evy, Mueller, Gabrielle S, Vanderkerken, Karin, Croucher, Peter I

“…Multiple myeloma is associated with the development of a devastating bone disease mediated by increased osteoclastic activity. The ligand for receptor…”
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CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis by Bhagawati-Prasad, Vijay Ns, De Leenheer, Evy, Keefe, Nadine P, Ryan, Lorna A, Carlring, Jennifer, Heath, Andrew W

“…Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the…”
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