Search Results - "De Lannoy, Inés A.M."

In vivo solid-phase microextraction liquid chromatography–tandem mass spectrometry for monitoring blood eicosanoids time profile after lipopolysaccharide-induced inflammation in Sprague-Dawley rats by Bessonneau, Vincent, Zhan, Yanwei, De Lannoy, Inés A.M., Saldivia, Victor, Pawliszyn, Janusz

“…•In vivo SPME LC–MS offers fast and non-lethal determination of blood eicosanoids.•SPME calibrated using pre-determined sampling rates.•Determination of…”
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Pharmacokinetics by Fan, Jianghong, de Lannoy, Inés A.M.

“…Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or new chemical…”
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The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin by de Lannoy, I A, Silverman, M

“…Digoxin, a widely used cardiac glycoside with a low therapeutic index, is known to interact with a large and diverse group of co-administered drugs, frequently…”
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Human Amyloid-β 40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo by Peng, H Benson, Noh, Keumhan, Pan, Sophie R, Saldivia, Victor, Serson, Sylvia, Toscan, Anja, de Lannoy, Inés A M, Pang, K Sandy

“…Amyloid-β peptides of 40 and 42 amino acid lengths, which are synthesized in neurons and degraded in the brain and liver, have the potential to aggregate and…”
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Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine:An Intracerebral Microdialysis Study in Conscious Rats by Durk, Matthew R., Fan, Jianghong, Sun, Huadong, Yang, Yingbo, Pang, Henrianna, Pang, K. Sandy, de Lannoy, Inés A. M.

“…Purpose Since the vitamin D receptor (VDR) was found to up-regulate cerebral P-glycoprotein expression in vitro and in mice, we extend our findings to rats by…”
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Overview of pharmacokinetics by Aimone, Lisa D, de Lannoy, Inés A M

“…In addition to having selective potency against the molecular target(s), a compound must be able to reach its intended site of action in vivo in sufficient…”
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Aging and brain free cholesterol concentration on amyloid‐β peptide accumulation in guinea pigs by Pang, K. Sandy, Peng, H. Benson, Li, Betty P., Wen, Binyu, Noh, Keumhan, Xia, Runyu, Toscan, Anja, Serson, Sylvia, Fraser, Paul E., Tirona, Rommel G., Lannoy, Inès A. M.

“…Alzheimer’s disease is a complex multifactorial neurodegenerative disorder wherein age is a major risk factor. The appropriateness of the Hartley guinea pig…”
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Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β‐amyloid peptide accumulation in mice by Peng, H. Benson, Bukuroshi, Paola, Durk, Matthew R., Grootendorst, Paul, Yan, Xiaoyu, Pan, Sophie R., Lannoy, Ines A. M., Pang, K. Sandy

“…Age, hypercholesterolemia, and vitamin D deficiency are risk factors that increase the brain accumulation of pathogenic β‐amyloid peptides (40 and 42),…”
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Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388 by Arastu‐Kapur, Shirin, Nguyen, Mai, Raha, Debasish, Ermini, Florian, Haditsch, Ursula, Araujo, Joseph, De Lannoy, Ines A. M., Ryder, Mark I., Dominy, Stephen S., Lynch, Casey, Holsinger, Leslie J.

“…COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with…”
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Studies To Examine Potential Tolerability Differences between the 5‑HT2C Receptor Selective Agonists Lorcaserin and CP-809101 by Higgins, Guy A, Silenieks, Leonardo B, Patrick, Amy, De Lannoy, Ines A. M, Fletcher, Paul J, Parker, Linda A, MacLusky, Neil J, Sullivan, Laura C, Chavera, Teresa A, Berg, Kelly A

“…Lorcaserin (LOR) is a selective 5-HT2C receptor agonist that has been FDA approved as a treatment for obesity. The most frequently reported side-effects of LOR…”
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Cyclosporin and quinidine inhibition of renal digoxin excretion: evidence for luminal secretion of digoxin by De Lannoy, I A, Koren, G, Klein, J, Charuk, J, Silverman, M

“…We studied the in vivo luminal and contraluminal uptake of [3H]digoxin in dog kidney using the single-pass multiple indicator dilution method. A bolus tracer…”
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Enalaprilat handling by the kidney: barrier-limited cell entry by Schwab, A J, de Lannoy, I A, Goresky, C A, Poon, K, Pang, K S

“…The angiotensin-converting enzyme inhibitor enalaprilat is formed in vivo in liver and kidney by esterolysis of the antihypertensive drug enalapril. To gain…”
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A physiological model for renal drug metabolism: enalapril esterolysis to enalaprilat in the isolated perfused rat kidney by de Lannoy, I A, Hirayama, H, Pang, K S

“…A physiologically based kidney model was developed to describe the metabolism of enalapril and explain the observed discrepancies between generated and…”
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Formed and preformed metabolite excretion clearances in liver, a metabolite formation organ: studies on enalapril and enalaprilat in the single-pass and recirculating perfused rat liver by de Lannoy, I A, Barker, 3rd, F, Pang, K S

“…Single-pass and recirculating rat liver perfusion studies were conducted with [14C]enalapril and [3H]enalaprilat, a precursor-product pair, and the data were…”
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Combined recirculation of the rat liver and kidney: studies with enalapril and enalaprilat by de Lannoy, I A, Pang, K S

“…Combined recirculation of the rat liver (L) and kidney (IPK) at 10 ml min-1 per organ (LK) was developed to examine the hepatorenal handling of the…”
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