Search Results - "De La Garza, Adriana"
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REPTOR and REPTOR-BP regulate organismal metabolism and transcription downstream of TORC1
Published in Developmental cell (04-05-2015)“…TORC1 regulates growth and metabolism in part by influencing transcriptional programs. We identify here REPTOR and REPTOR-BP as transcription factors…”
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2
RAC1b Overexpression Confers Resistance to Chemotherapy Treatment in Colorectal Cancer
Published in Molecular cancer therapeutics (01-05-2019)“…Resistance to chemotherapy represents a major limitation in the treatment of colorectal cancer. Novel strategies to circumvent resistance are critical to…”
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3
The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish
Published in Blood advances (23-07-2019)“…The spliceosomal component Splicing Factor 3B, subunit 1 (SF3B1) is one of the most prevalently mutated factors in the bone marrow failure disorder…”
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CHD1 - a Novel Epigenetic Regulator in Myeloid Malignancies with a Role in DNA Repair
Published in Blood (29-11-2018)“…Myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML) are clonal hematopoietic disorders resulting from genetic alterations in hematopoietic stem…”
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Abstract 4824: Rac1b overexpression confers resistance to chemotherapy treatment in colorectal cancer
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Acquired resistance to chemotherapy represents a major limitation in the treatment of colorectal cancer. New strategies to circumvent this problem are critical…”
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The spliceosomal component SF3B1 is essential for proper erythroid differentiation and gene expression in zebrafish
Published in Experimental hematology (01-09-2017)Get full text
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Spliceosomal component Sf3b1 is essential for hematopoietic differentiation in zebrafish
Published in Experimental hematology (01-09-2016)“…SF3B1 ( Splicing factor 3b , subunit 1 ) is one of the most commonly mutated factors in myelodysplastic syndrome (MDS). Although the genetic correlation…”
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Concise Review: Hematopoietic Stem Cell Origins: Lessons From Embryogenesis for Improving Regenerative Medicine
Published in Stem cells translational medicine (02-08-2016)“…: Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood cell types, an ability that is harnessed in the clinic for bone…”
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A Chemical Modifier Screen in Zebrafish Mutants for the Spliceosomal Component Sf3b1reveals Genotype-Selective Vulnerabilities
Published in Blood (02-12-2016)“…Myelodysplastic syndrome (MDS) is a disorder arising from hematopoietic stem and progenitor cell (HSPC) dysfunction resulting in ineffective hematopoiesis…”
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10
Concise Review: Hematopoietic Stem Cell Origins: Lessons from Embryogenesis for Improving Regenerative Medicine
Published in Stem cells translational medicine (01-01-2017)“…Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood cell types, an ability that is harnessed in the clinic for bone…”
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11
The spliceosomal component SF3B1 is essential for hematopoietic differentiation and splicing fidelity
Published in Experimental hematology (01-09-2016)Get full text
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12
The Spliceosomal Component Sf3b1 Is Essential for Hematopoietic Differentiation
Published in Blood (03-12-2015)“…Myelodysplastic syndrome (MDS) is a disorder arising from hematopoietic stem and progenitor cell (HSPC) dysfunction resulting in ineffective hematopoiesis. A…”
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Interactions between the chromatin remodeller CHD1 and the spliceosome are critical for hematopoietic stem and progenitor cell emergence
Published in Experimental hematology (01-08-2014)Get full text
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14
Deciphering the role of SF3B1 in hematopoiesis
Published 01-01-2017“…Hematologic malignancies claim the lives of many people every year, yet we lack a complete understanding of the mechanisms of pathogenesis behind them…”
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Dissertation