Search Results - "De Kaste, D."

The identification of (−)- trans-tadalafil, tadalafil, and sildenafil in counterfeit Cialis ® and the optical purity of tadalafil stereoisomers by Venhuis, B.J., Zomer, G., Vredenbregt, M.J., de Kaste, D.

“…Four blisters with suspect Cialis ® (tadalafil) 20 mg tablets were screened for authenticity using near infrared spectroscopy (NIRS) and for the presence of…”
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Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: A history, analytical aspects and health risks by Venhuis, B.J., de Kaste, D.

“…► Analogues of sildenafil, tadalafil, and vardenafil are predominantly found as adulterants in food supplements. ► Analogues are essentially experimental drugs…”
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Sildenafil and analogous phosphodiesterase type 5 (PDE-5) inhibitors in herbal food supplements sampled on the Dutch market by Reeuwijk, N.M, Venhuis, B.J, de Kaste, D, Hoogenboom, L.A.P, Rietjens, I.M.C.M, Martena, M.J

“…Herbal food supplements, claiming to enhance sexual potency, may contain deliberately added active pharmacological ingredients (APIs) that can be used for the…”
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Structure elucidation of sildenafil analogues in herbal products by Blok-Tip, L, Zomer, B, Bakker, F, Hartog, K D, Hamzink, M, Ten Hove, J, Vredenbregt, M, De Kaste, D

“…The structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry,…”
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Dose-to-dose variations with single packages of counterfeit medicines and adulterated dietary supplements as a potential source of false negatives and inaccurate health risk assessments by Venhuis, B J, Zwaagstra, M E, Keizers, P H J, de Kaste, D

“…In this report, we show three examples of how the variability in dose units in single packages of counterfeit medicines and adulterated dietary supplements may…”
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Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac by Venhuis, B.J., Zomer, G., de Kaste, D.

“…A new analogue of sildenafil was detected in a herbal aphrodisiac. The structure of the compound was established using LC–MS, UV and IR spectroscopy, MS–MS,…”
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Screening suspected counterfeit Viagra ® and imitations of Viagra ® with near-infrared spectroscopy by Vredenbregt, M.J., Blok-Tip, L., Hoogerbrugge, R., Barends, D.M., Kaste, D. de

“…We describe a near-infrared spectroscopy (NIRS) method for fast-screening Viagra ® tablets, counterfeit Viagra tablets, and imitations of Viagra. The method…”
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Pharmacologically effective red yeast rice preparations marketed as dietary supplements illustrated by a case report by Venhuis, B.J., van Hunsel, F., van de Koppel, S., Keizers, P.H.J., Jeurissen, S.M.F., De Kaste, D.

“…This paper reports a typical statin‐related adverse reaction from a red yeast rice (RYR) supplement and the analytical findings from the supplement. It also…”
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The identification of rimonabant polymorphs, sibutramine and analogues of both in counterfeit Acomplia bought on the internet by Venhuis, B.J., Vredenbregt, M.V., Kaun, N., Maurin, J.K., Fijałek, Z., de Kaste, D.

“…Acomplia was ordered over the internet resulting in the delivery of counterfeit Acomplia and imitation products. The tablets were analyzed for the presence of…”
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Detection of Lipitor ® counterfeits: A comparison of NIR and Raman spectroscopy in combination with chemometrics by de Peinder, P., Vredenbregt, M.J., Visser, T., de Kaste, D.

“…Research has been carried on the feasibility of near infrared (NIR) and Raman spectroscopy as rapid screening methods to discriminate between genuine and…”
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Consistency of FMEA used in the validation of analytical procedures by Oldenhof, M.T., van Leeuwen, J.F., Nauta, M.J., de Kaste, D., Odekerken-Rombouts, Y.M.C.F., Vredenbregt, M.J., Weda, M., Barends, D.M.

“…In order to explore the consistency of the outcome of a Failure Mode and Effects Analysis (FMEA) in the validation of analytical procedures, an FMEA was…”
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The identification of a nitrosated prodrug of the PDE-5 inhibitor aildenafil in a dietary supplement: A Viagra with a pop by Venhuis, B.J., Zomer, G., Hamzink, M., Meiring, H.D., Aubin, Y., de Kaste, D.

“…A new unapproved analogue of sildenafil was detected in capsules of a herbal dietary supplement promoted as a libido enhancing product. Using LC–DAD–MS, MS–MS,…”
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Risk analysis by FMEA as an element of analytical validation by van Leeuwen, J.F., Nauta, M.J., de Kaste, D., Odekerken-Rombouts, Y.M.C.F., Oldenhof, M.T., Vredenbregt, M.J., Barends, D.M.

“…We subjected a Near-Infrared (NIR) analytical procedure used for screening drugs on authenticity to a Failure Mode and Effects Analysis (FMEA), including…”
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Analysis of optically active compounds using conventional chromatography with a circular dichroism detector by Slijkhuis, C, Hartog, K.D, van Alphen, C, Blok-Tip, L, Jongen, P.M.J.M, de Kaste, D

“…Analysis of optically active compounds in complex samples is often based on chiral chromatography or capillary electrophoresis in order to separate the…”
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Results of a market surveillance study in The Netherlands on break-mark tablets by Barends, D M, Groot, D W, van der Steen, J C, de Kaste, D, Frijlink, H W

“…A representative market surveillance study on break-mark tablets for human use, having a marketing authorization (MA) in The Netherlands (NL), was carried out…”
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An improved in vitro method for the evaluation of antacids with in vivo relevance by van Riet-Nales, D.A, van Aalst, P, de Kaste, D, Barends, D.M

“…An improved in vitro method for the evaluation of antacids for use with standard equipment is described. The method is a modification of an older method (RIGO…”
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Disintegration of sublingual tablets: proposal for a validated test method and acceptance criterion by Weda, M, van Riet-Nales, D A, van Aalst, P, de Kaste, D, Lekkerkerker, J F F

“…In the Netherlands the market share of isosorbide dinitrate 5 mg sublingual tablets is dominated by 2 products (A and B). In the last few years complaints have…”
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Pharmaceutical analysis of the oral iron chelator deferiprone (DMHP,L1) by Lange, R, Lameijer, W, Slijkhuis, C, de Kaste, D

“…The oral iron chelator deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one, DMHP, LT or CP20) can be a useful drug in patients with transfusional hemosiderosis…”
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Computer modelling of the binding of non-selective ligands to biological receptors by Wynne, H J, De Kaste, D, Soudijn, W

“…The application of common linearization methods (log-probit analysis or Hill plot transformation) to the evaluation of receptor binding experiments leads to…”
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Active pharmaceutical ingredients detected in herbal food supplements for weight loss samples on the Dutch market by Reeuwijk, N.M, Venhuis, B.J, Kaste, D., de, Hoogenboom, L.A.P, Rietjens, I, Martena, M.J

“…Herbal food supplements claiming to reduce weight may contain active pharmacological ingredients (APIs) that can be used for the treatment of overweight and…”
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