The influence of maternal immunity on the development of the in vitro lymphocyte proliferation response against pseudorabies virus in pigs

The influence of maternal immunity on the development of the in vitro lymphocyte proliferation response against pseudorabies virus in pigs

In this study, the influence of maternal immunity against pseudorabies virus (PRv) on the development of a PRV-specific T-cell response in pigs was investigated. Pigs with or without maternal immunity were challenged by inoculation with wild-type PRv, or were vaccinated with 783 and subsequently ino...

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Bibliographic Details
Published in:Research in veterinary science Vol. 64; no. 2; pp. 167 - 171
Main Authors: Bouma, A., De Jong, M.D.M., Kimman, T.G.
Format: Journal Article
Language:English
Published: England Elsevier India Pvt Ltd 01-03-1998
Subjects:
Animals
Female
Herpesvirus 1, Suid - immunology
ID Lelystad, Institute for Animal Science and Health
ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid
Immunity, Maternally-Acquired
Lymphocyte Activation
Lymphocytes - immunology
Lymphocytes - virology
Pregnancy
Pseudorabies - immunology
Pseudorabies - prevention & control
Pseudorabies Vaccines
Swine
Vaccines, Inactivated
Viral Vaccines
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Summary:In this study, the influence of maternal immunity against pseudorabies virus (PRv) on the development of a PRV-specific T-cell response in pigs was investigated. Pigs with or without maternal immunity were challenged by inoculation with wild-type PRv, or were vaccinated with 783 and subsequently inoculated. Peripheral blood lymphocytes, collected after vaccination and/or inoculation, were used for PRV-induced lymphocyte proliferation assays in vitro as a measure of a PRv-specific T-cell response. In unvaccinated pigs, the presence of maternal immunity did not inhibit the development of a T-cell response after inoculation with PRv. In contrast, maternal immunity did inhibit the development of a PRV-induced response after intramuscular vaccination. Moreover, vaccinated pigs without maternal immunity shed virus for a shorter period after inoculation than vaccinated pigs with maternal immunity. The greater T-cell response induced by the vaccine might have contributed to the more rapid clearance of PRV in these pigs.
Bibliography:ObjectType-Article-1
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ISSN:0034-5288
1532-2661
DOI:10.1016/S0034-5288(98)90014-5