Search Results - "De Jong, Kirstie A"

The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice by Venardos, Kylie, De Jong, Kirstie A, Elkamie, Mansour, Connor, Timothy, McGee, Sean L

“…The development of diabetic cardiomyopathy is a key contributor to heart failure and mortality in obesity and type 2 diabetes (T2D). Current therapeutic…”
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Complex Energy Metabolic Changes in Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction by De Jong, Kirstie A., BMedSci (hons), Lopaschuk, Gary D., PhD

“…Abstract Alterations in cardiac energy metabolism contribute to the severity of heart failure. However, the energy metabolic changes that occur in heart…”
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Live-cell imaging identifies cAMP microdomains regulating β-adrenoceptor-subtype-specific lipolytic responses in human white adipocytes by De Jong, Kirstie A., Ehret, Sandra, Heeren, Joerg, Nikolaev, Viacheslav O.

“…Lipolysis of stored triglycerides is stimulated via β-adrenergic receptor (β-AR)/3′,5′-cyclic adenosine monophosphate (cAMP) signaling and inhibited via…”
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Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women by De Jong, Kirstie A, Berisha, Filip, Naderpoor, Negar, Appelbe, Alan, Kotowicz, Mark A, Cukier, Kimberly, McGee, Sean L, Nikolaev, Viacheslav O

“…It remains unclear as to whether polycystic ovary syndrome (PCOS) is an additional risk factor in the development of left ventricular (LV) hypertrophy in obese…”
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Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity by Hall, Liam G., Czeczor, Juliane K., Connor, Timothy, Botella, Javier, De Jong, Kirstie A., Renton, Mark C., Genders, Amanda J., Venardos, Kylie, Martin, Sheree D., Bond, Simon T., Aston-Mourney, Kathryn, Howlett, Kirsten F., Campbell, James A., Collier, Greg R., Walder, Ken R., McKenzie, Matthew, Ziemann, Mark, McGee, Sean L.

“…There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. The role of amyloid beta 42 (Aβ 42…”
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Impact of maternal high fat diet on hypothalamic transcriptome in neonatal Sprague Dawley rats by Barrand, Sanna, Crowley, Tamsyn M, Wood-Bradley, Ryan J, De Jong, Kirstie A, Armitage, James A

“…Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to…”
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Understanding the Role of SERCA2a Microdomain Remodeling in Heart Failure Induced by Obesity and Type 2 Diabetes by Lai, Ping, Nikolaev, Viacheslav O, De Jong, Kirstie A

“…Obesity and type 2 diabetes (T2D) are on trend to become a huge burden across all ages. They cause harm to almost every organ, especially the heart. For…”
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APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding by Czeczor, Juliane K, Genders, Amanda J, Aston-Mourney, Kathryn, Connor, Timothy, Hall, Liam G, Hasebe, Kyoko, Ellis, Megan, De Jong, Kirstie A, Henstridge, Darren C, Meikle, Peter J, Febbraio, Mark A, Walder, Ken, McGee, Sean L

“…The amyloid precursor protein (APP) generates a number of peptides when processed through different cleavage mechanisms, including the amyloid beta peptide…”
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CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms by Skryabin, Egor B, De Jong, Kirstie A, Subramanian, Hariharan, Bork, Nadja I, Froese, Alexander, Skryabin, Boris V, Nikolaev, Viacheslav O

“…Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic…”
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Cardiac Hypertrophy Changes Compartmentation of cAMP in Non-Raft Membrane Microdomains by Pavlaki, Nikoleta, De Jong, Kirstie A, Geertz, Birgit, Nikolaev, Viacheslav O, Froese, Alexander

“…3',5'-Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger which plays critical roles in cardiac function and disease. In adult mouse…”
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Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity by De Jong, Kirstie A., Hall, Liam G., Renton, Mark C., Connor, Timothy, Martin, Sheree D., Kowalski, Greg M., Shaw, Christopher S., Bruce, Clinton R., Howlett, Kirsten F., McGee, Sean L.

“…Protein kinase D (PKD) signaling has been implicated in stress-induced cardiac remodeling and function as well as metabolic processes including…”
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Multifaceted remodelling of cAMP microdomains driven by different aetiologies of heart failure by De Jong, Kirstie A., Nikolaev, Viacheslav O.

“…Heart failure with preserved ejection fraction (HFpEF) will soon take over as the predominant form of heart failure. This is largely driven by the continuing…”
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Erratum to: Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study by De Jong, Kirstie A, Czeczor, Juliane K, Sithara, Smithamol, McEwen, Kevin, Lopaschuk, Gary D, Appelbe, Alan, Cukier, Kimberly, Kotowicz, Mark, McGee, Sean L

“…After publication of the original article [1], it came to the authors’ attention that in the author list Gary Lopaschuk’s surname originally contained a typo…”
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The role of compartmentalized β-AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes by De Jong, Kirstie A, Siddig, Sana, Pfeifer, Alexander, Nikolaev, Viacheslav O

“…White and brown adipocytes are central mediators of lipid metabolism and thermogenesis, respectively. Their function is tightly regulated by all three…”
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Remodelling of cAMP dynamics within the SERCA2a microdomain in heart failure with preserved ejection fraction caused by obesity and type 2 diabetes by Lai, Ping, Hille, Susanne S, Subramanian, Hariharan, Wiegmann, Robert, Roser, Pia, Müller, Oliver J, Nikolaev, Viacheslav O, De Jong, Kirstie A

“…Abstract Aims Despite massive efforts, we remain far behind in our attempts to identify effective therapies to treat heart failure with preserved ejection…”
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Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation by Jungen, Christiane, Scherschel, Katharina, Flenner, Frederik, Jee, Haesung, Rajendran, Pradeep, De Jong, Kirstie A, Nikolaev, Viacheslav, Meyer, Christian, Ardell, Jeffrey L, Tompkins, John D

“…Patients with type 2 diabetes mellitus (T2DM) have a greater risk of developing life-threatening cardiac arrhythmias. Because the underlying mechanisms and…”
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Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation by Pavlaki, Nikoleta, Froese, Alexander, Li, Wener, De Jong, Kirstie A, Geertz, Birgit, Subramanian, Hariharan, Mohagaonkar, Sanika, Luo, Xiaojing, Schubert, Mario, Wiegmann, Robert, Margaria, Jean Piero, Ghigo, Alessandra, Kämmerer, Susanne, Hirsch, Emilio, El-Armouche, Ali, Guan, Kaomei, Nikolaev, Viacheslav O

“…Abstract Aims Gene therapy with cardiac phosphodiesterases (PDEs), such as phosphodiesterase 4B (PDE4B), has recently been described to effectively prevent…”
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Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study by De Jong, Kirstie A, Czeczor, Juliane K, Sithara, Smithamol, McEwen, Kevin, Lopaschuk, Gary D, Appelbe, Alan, Cukier, Kimberly, Kotowicz, Mark, McGee, Sean L

“…It is unclear whether obesity and type 2 diabetes (T2D), either alone or in combination, induce left ventricular hypertrophy (LVH) independent of hypertension…”
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