Search Results - "De Jesus, Dario F."

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses by Kahraman, Sevim, Shibue, Kimitaka, De Jesus, Dario F, Kim, Hyunki, Hu, Jiang, Manna, Debasish, Wagner, Bridget, Choudhary, Amit, Kulkarni, Rohit N

“…Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the…”
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RADAR: differential analysis of MeRIP-seq data with a random effect model by Zhang, Zijie, Zhan, Qi, Eckert, Mark, Zhu, Allen, Chryplewicz, Agnieszka, De Jesus, Dario F, Ren, Decheng, Kulkarni, Rohit N, Lengyel, Ernst, He, Chuan, Chen, Mengjie

“…Epitranscriptome profiling using MeRIP-seq is a powerful technique for in vivo functional studies of reversible RNA modifications. We develop RADAR, a…”
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Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway by Shirakawa, Jun, Tajima, Kazuki, Okuyama, Tomoko, Kyohara, Mayu, Togashi, Yu, De Jesus, Dario F., Basile, Giorgio, Kin, Tatsuya, Shapiro, A. M. James, Kulkarni, Rohit N., Terauchi, Yasuo

“…Aims/hypothesis Sodium–glucose cotransporter 2 (SGLT2) inhibitors, which prevent the renal reabsorption of glucose, decrease blood glucose levels in an…”
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SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes by Sabadell-Basallote, Joan, Astiarraga, Brenno, Castaño, Carlos, Ejarque, Miriam, Repollés-de-Dalmau, Maria, Quesada, Ivan, Blanco, Jordi, Nuñez-Roa, Catalina, Rodríguez-Peña, M-Mar, Martínez, Laia, De Jesus, Dario F, Marroqui, Laura, Bosch, Ramon, Montanya, Eduard, Sureda, Francesc X, Tura, Andrea, Mari, Andrea, Kulkarni, Rohit N, Vendrell, Joan, Fernández-Veledo, Sonia

“…Pancreatic β-cell dysfunction is a key feature of type 2 diabetes, and novel regulators of insulin secretion are desirable. Here we report that the succinate…”
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Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts by Gupta, Manoj K., Teo, Adrian Kee Keong, Rao, Tata Nageswara, Bhatt, Shweta, Kleinridders, Andre, Shirakawa, Jun, Takatani, Tomozumi, Hu, Jiang, De Jesus, Dario F., Windmueller, Rebecca, Wagers, Amy J., Kulkarni, Rohit N.

“…Primary human fibroblasts were cultured in either insulin‐rich defined medium or in a conventional medium to study the significance of proliferation/growth…”
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Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice by Wang, Xuanchun, Li, Yanliang, Qiang, Guifen, Wang, Kaihua, Dai, Jiarong, McCann, Maximilian, Munoz, Marcos D., Gil, Victoria, Yu, Yifei, Li, Shengxian, Yang, Zhihong, Xu, Shanshan, Cordoba-Chacon, Jose, De Jesus, Dario F., Sun, Bei, Chen, Kuangyang, Wang, Yahao, Liu, Xiaoxia, Miao, Qing, Zhou, Linuo, Hu, Renming, Ding, Qiang, Kulkarni, Rohit N., Gao, Daming, Blüher, Matthias, Liew, Chong Wee

“…Secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) is a poorly characterized secreted protein of largely unknown physiological…”
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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance by Shirakawa, Jun, Togashi, Yu, Basile, Giorgio, Okuyama, Tomoko, Inoue, Ryota, Fernandez, Megan, Kyohara, Mayu, De Jesus, Dario F., Goto, Nozomi, Zhang, Wei, Tsuno, Takahiro, Kin, Tatsuya, Pan, Hui, Dreyfuss, Jonathan M., Shapiro, A.M. James, Yi, Peng, Terauchi, Yasuo, Kulkarni, Rohit N.

“…Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes. Here, we report the pathways utilized by β cells to robustly…”
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“Omics” and “epi-omics” underlying the β-cell adaptation to insulin resistance by De Jesus, Dario F., Kulkarni, Rohit N.

“…Pancreatic β-cells adapt to high metabolic demand by expanding their β-cell mass and/or enhancing insulin secretion to maintain glucose homeostasis. Type 2…”
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Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation by Gupta, Manoj K., De Jesus, Dario F., Kahraman, Sevim, Valdez, Ivan A., Shamsi, Farnaz, Yi, Lian, Swensen, Adam C., Tseng, Yu-Hua, Qian, Wei-Jun, Kulkarni, Rohit N.

“…Insulin receptor (IR)-mediated signaling is involved in the regulation of pluripotent stem cells; however, its direct effects on regulating the maintenance of…”
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NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes by De Jesus, Dario F, Kimura, Tomohiko, Gupta, Manoj K, Kulkarni, Rohit N

“…Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. We recently discovered that neuronal regeneration-related protein…”
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m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation by Kahraman, Sevim, De Jesus, Dario F, Wei, Jiangbo, Brown, Natalie K, Zou, Zhongyu, Hu, Jiang, Pirouz, Mehdi, Gregory, Richard I, He, Chuan, Kulkarni, Rohit N

“…N 6 -methyladenosine (m 6 A) is the most abundant chemical modification in mRNA and plays important roles in human and mouse embryonic stem cell pluripotency,…”
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Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice by De Jesus, Dario F, Orime, Kazuki, Kaminska, Dorota, Kimura, Tomohiko, Basile, Giorgio, Wang, Chih-Hao, Haertle, Larissa, Riemens, Renzo, Brown, Natalie K, Hu, Jiang, Männistö, Ville, Silva, Amélia M, Dirice, Ercument, Tseng, Yu-Hua, Haaf, Thomas, Pihlajamäki, Jussi, Kulkarni, Rohit N

“…The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology…”
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Epigenetic modifiers of islet function and mass by De Jesus, Dario F, Kulkarni, Rohit N

“…Highlights • The underlying mechanisms that increase susceptibility of an individual to develop type 2 diabetes implicate epigenetics. • Both aging and…”
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SerpinB1 Promotes Pancreatic β Cell Proliferation by El Ouaamari, Abdelfattah, Dirice, Ercument, Gedeon, Nicholas, Hu, Jiang, Zhou, Jian-Ying, Shirakawa, Jun, Hou, Lifei, Goodman, Jessica, Karampelias, Christos, Qiang, Guifeng, Boucher, Jeremie, Martinez, Rachael, Gritsenko, Marina A., De Jesus, Dario F., Kahraman, Sevim, Bhatt, Shweta, Smith, Richard D., Beer, Hans-Dietmar, Jungtrakoon, Prapaporn, Gong, Yanping, Goldfine, Allison B., Liew, Chong Wee, Doria, Alessandro, Andersson, Olov, Qian, Wei-Jun, Remold-O’Donnell, Eileen, Kulkarni, Rohit N.

“…Although compensatory islet hyperplasia in response to insulin resistance is a recognized feature in diabetes, the factor(s) that promote β cell proliferation…”
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Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes by De Jesus, Dario F., Zhang, Zijie, Brown, Natalie K., Li, Xiaolu, Xiao, Ling, Hu, Jiang, Gaffrey, Matthew J., Fogarty, Garrett, Kahraman, Sevim, Wei, Jiangbo, Basile, Giorgio, Rana, Tariq M., Mathews, Clayton, Powers, Alvin C., Parent, Audrey V., Atkinson, Mark A., Dhe-Paganon, Sirano, Eizirik, Decio L., Qian, Wei-Jun, He, Chuan, Kulkarni, Rohit N.

“…Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed the interest in β-cell RNA sensors and…”
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Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring by Kahraman, Sevim, Dirice, Ercument, De Jesus, Dario F, Hu, Jiang, Kulkarni, Rohit N

“…Studies in both humans and rodents suggest that maternal diabetes leads to a higher risk of the fetus developing impaired glucose tolerance and obesity during…”
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Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia by St-Louis, Johanna L., El Jellas, Khadija, Velasco, Kelly, Slipp, Brittany A., Hu, Jiang, Helgeland, Geir, Steine, Solrun J., De Jesus, Dario F., Kulkarni, Rohit N., Molven, Anders

“…Congenital hyperinsulinism of infancy (CHI) can be caused by a deficiency of the ubiquitously expressed enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase…”
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Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b by Patel, Suraj J, Liu, Nan, Piaker, Sam, Gulko, Anton, Andrade, Maynara L, Heyward, Frankie D, Sermersheim, Tyler, Edinger, Nufar, Srinivasan, Harini, Emont, Margo P, Westcott, Gregory P, Luther, Jay, Chung, Raymond T, Yan, Shuai, Kumari, Manju, Thomas, Reeby, Deleye, Yann, Tchernof, André, White, Phillip J, Baselli, Guido A, Meroni, Marica, De Jesus, Dario F, Ahmad, Rasheed, Kulkarni, Rohit N, Valenti, Luca, Tsai, Linus, Rosen, Evan D

“…Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here,…”
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A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism by Pradas-Juni, Marta, Hansmeier, Nils R., Link, Jenny C., Schmidt, Elena, Larsen, Bjørk Ditlev, Klemm, Paul, Meola, Nicola, Topel, Hande, Loureiro, Rute, Dhaouadi, Ines, Kiefer, Christoph A., Schwarzer, Robin, Khani, Sajjad, Oliverio, Matteo, Awazawa, Motoharu, Frommolt, Peter, Heeren, Joerg, Scheja, Ludger, Heine, Markus, Dieterich, Christoph, Büning, Hildegard, Yang, Ling, Cao, Haiming, Jesus, Dario F. De, Kulkarni, Rohit N., Zevnik, Branko, Tröder, Simon E., Knippschild, Uwe, Edwards, Peter A., Lee, Richard G., Yamamoto, Masayuki, Ulitsky, Igor, Fernandez-Rebollo, Eduardo, Vallim, Thomas Q. de Aguiar, Kornfeld, Jan-Wilhelm

“…Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism…”
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Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes by Jungtrakoon, Prapaporn, Shirakawa, Jun, Buranasupkajorn, Patinut, Gupta, Manoj K, De Jesus, Dario F, Pezzolesi, Marcus G, Panya, Aussara, Hastings, Timothy, Chanprasert, Chutima, Mendonca, Christine, Kulkarni, Rohit N, Doria, Alessandro

“…Solute Carrier Family 19 Member 2 ( ) encodes thiamine transporter 1 (THTR1), which facilitates thiamine transport across the cell membrane. homozygous…”
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