Search Results - "De Jager, A"

Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial by Smith, A David, Smith, Stephen M, de Jager, Celeste A, Whitbread, Philippa, Johnston, Carole, Agacinski, Grzegorz, Oulhaj, Abderrahim, Bradley, Kevin M, Jacoby, Robin, Refsum, Helga

“…An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor…”
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Targeting Inflammation after Myocardial Infarction: A Therapeutic Opportunity for Extracellular Vesicles? by Viola, Margarida, de Jager, Saskia C. A., Sluijter, Joost P. G.

“…After myocardial infarction (MI), a strong inflammatory response takes place in the heart to remove the dead tissue resulting from ischemic injury. A growing…”
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Size and Molecular Flexibility of Sugars Determine the Storage Stability of Freeze-Dried Proteins by Tonnis, W. F, Mensink, M. A, de Jager, A, van der Voort Maarschalk, K, Frijlink, H. W, Hinrichs, W. L. J

“…Protein-based biopharmaceuticals are generally produced as aqueous solutions and stored refrigerated to obtain sufficient shelf life. Alternatively, proteins…”
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Associations of Social Isolation with Anxiety and Depression During the Early COVID-19 Pandemic: A Survey of Older Adults in London, UK by Robb, Catherine E, de Jager, Celeste A, Ahmadi-Abhari, Sara, Giannakopoulou, Parthenia, Udeh-Momoh, Chinedu, McKeand, James, Price, Geraint, Car, Josip, Majeed, Azeem, Ward, Helen, Middleton, Lefkos

“…The COVID-19 pandemic is imposing a profound negative impact on the health and wellbeing of societies and individuals, worldwide. One concern is the effect of…”
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Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells by Frodermann, Vanessa, Rohde, David, Courties, Gabriel, Severe, Nicolas, Schloss, Maximilian J., Amatullah, Hajera, McAlpine, Cameron S., Cremer, Sebastian, Hoyer, Friedrich F., Ji, Fei, van Koeverden, Ian D., Herisson, Fanny, Honold, Lisa, Masson, Gustavo Santos, Zhang, Shuang, Grune, Jana, Iwamoto, Yoshiko, Schmidt, Stephen P., Wojtkiewicz, Gregory R., Lee, I-Hsiu, Gustafsson, Karin, Pasterkamp, Gerard, de Jager, Saskia C. A., Sadreyev, Ruslan I., MacFadyen, Jean, Libby, Peter, Ridker, Paul, Scadden, David T., Naxerova, Kamila, Jeffrey, Kate L., Swirski, Filip K., Nahrendorf, Matthias

“…A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis; however, it remains unclear whether regular physical activity influences…”
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Connected speech as a marker of disease progression in autopsy-proven Alzheimer's disease by AHMED, Samrah, HAIGH, Anne-Marie F, DE JAGER, Celeste A, GARRARD, Peter

“…Although an insidious history of episodic memory difficulty is a typical presenting symptom of Alzheimer's disease, detailed neuropsychological profiling…”
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Practice Effect of Repeated Cognitive Tests Among Older Adults: Associations With Brain Amyloid Pathology and Other Influencing Factors by Zheng, Bang, Udeh-Momoh, Chinedu, Watermeyer, Tamlyn, de Jager Loots, Celeste A., Ford, Jamie K., Robb, Catherine E., Giannakopoulou, Parthenia, Ahmadi-Abhari, Sara, Baker, Susan, Novak, Gerald P., Price, Geraint, Middleton, Lefkos T.

“…Background: Practice effects (PE), after repeated cognitive measurements, may mask cognitive decline and represent a challenge in clinical and research…”
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Utility of TICS-M for the assessment of cognitive function in older adults by de Jager, Celeste A., Budge, Marc M., Clarke, Robert

“…Background Routine screening of high‐risk elderly people for early cognitive impairment is constrained by the limitations of currently available cognitive…”
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Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload by Wang, Jiong-Wei, Fontes, Magda S. C., Wang, Xiaoyuan, Chong, Suet Yen, Kessler, Elise L., Zhang, Ya-Nan, de Haan, Judith J., Arslan, Fatih, de Jager, Saskia C. A., Timmers, Leo, van Veen, Toon A. B., Lam, Carolyn S. P., Kleijn, Dominique P. V. de

“…An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic…”
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Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease by De Jager, C A, Hogervorst, E, Combrinck, M, Budge, M M

“…Early diagnosis of dementia is important for those who might benefit from treatment. We designed a brief comprehensive neuropsychological test battery to help…”
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Potential of mesenchymal- and cardiac progenitor cells for therapeutic targeting of B-cells and antibody responses in end-stage heart failure by van den Hoogen, Patricia, de Jager, Saskia C A, Mol, Emma A, Schoneveld, Arjan S, Huibers, Manon M H, Vink, Aryan, Doevendans, Pieter A, Laman, Jon D, Sluijter, Joost P G

“…Upon myocardial damage, the release of cardiac proteins induces a strong antibody-mediated immune response, which can lead to adverse cardiac remodeling and…”
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NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction by Silvis, Max J M, Demkes, Evelyne J, Timmers, Leo, Arslan, Fatih, de Jager, Saskia C A, Sluijter, Joost P G, Mosterd, Arend, de Kleijn, Dominique P V, Bosch, Lena, van Hout, Gerardus P J

“…NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent of myocardial damage after myocardial infarction (MI). The purpose…”
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Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial by de Jager, Celeste A., Oulhaj, Abderrahim, Jacoby, Robin, Refsum, Helga, Smith, A. David

“…Background Homocysteine is a risk factor for Alzheimer's disease. In the first report on the VITACOG trial, we showed that homocysteine‐lowering treatment with…”
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Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment by Douaud, Gwenaëlle, Refsum, Helga, de Jager, Celeste A., Jacoby, Robin, Nichols, Thomas E., Smith, Stephen M., Smith, A. David

“…Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer’s disease (AD)? One approach is to modify nongenetic risk…”
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Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival by van den Hoogen, Patricia, Huibers, Manon M H, van den Dolder, Floor W, de Weger, Roel, Siera-de Koning, Erica, Oerlemans, Marish I F, de Jonge, Nicolaas, van Laake, Linda W, Doevendans, Pieter A, Sluijter, Joost P G, Vink, Aryan, de Jager, Saskia C A

“…Cardiac allograft vasculopathy (CAV) and antibody-mediated rejection are immune-mediated, long-term complications that jeopardize graft survival after heart…”
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Activity and Concentration of Polyphenolic Antioxidants in Apple:  Effect of Cultivar, Harvest Year, and Storage Conditions by van der Sluis, Addie A, Dekker, Matthijs, de Jager, Anton, Jongen, Wim M. F

“…Consumers' increasing interest in the relationship between diet and health is a sign for food producers to pay more attention to potential health-protecting…”
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An assessment of neurocognitive speed in relation to frailty by Rolfson, Darryl B, Wilcock, Gordon, Mitnitski, Arnold, King, Elizabeth, de Jager, Celeste A, Rockwood, Kenneth, Fallah, Nader, Searle, Samuel D

“…to evaluate the relationship between neurocognitive speed (NCS) and frailty; to consider how this relationship is affected by how frailty is operationalised…”
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Logopenic aphasia in Alzheimer's disease: clinical variant or clinical feature? by Ahmed, Samrah, de Jager, Celeste A, Haigh, Anne-Marie F, Garrard, Peter

“…BackgroundPrimary progressive aphasia (PPA) is a clinical syndrome characterised by progressive decline in components of the language system. Recent evidence…”
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Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus by Reijrink, M, van Ark, J, Lexis, C P H, Visser, L M, Lodewijk, M E, van der Horst, I C C, Zeebregts, C J, van Goor, H, de Jager, S C A, Pasterkamp, G, Wolffenbuttel, B H R, Hillebrands, J L

“…Individuals with type 2 diabetes mellitus (T2DM) have an increased risk for developing macrovascular disease (MVD) manifested by atherosclerosis…”
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Transition from physical to virtual visit format for a longitudinal brain aging study, in response to the Covid‐19 pandemic. Operationalizing adaptive methods and challenges by Udeh‐Momoh, Chinedu Theresa, Jager‐Loots, Celeste A., Price, Geraint, Middleton, Lefkos T.

“…The COVID‐19 pandemic necessitated adaptations to standard operations and management of clinical studies, after lockdown measures put in place by several…”
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