Search Results - "De Ioris, Maria Antonietta"
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Humoral and cellular immune response after mRNA SARS-CoV-2 vaccine in children on treatment for cancer: A pilot observational study
Published in Heliyon (30-07-2024)“…Immunocompromised children are at risk of developing severe COVID-19 infection. We conducted a pilot prospective study to evaluate the impact of cancer…”
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Two bullets in the gun: combining immunotherapy with chemotherapy to defeat neuroblastoma by targeting adrenergic-mesenchymal plasticity
Published in Frontiers in immunology (02-10-2023)“…Neuroblastoma (NB) is a childhood tumor that originates in the peripheral sympathetic nervous system and is responsible for 15% of cancer-related deaths in the…”
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DICER1 Syndrome and Cancer Predisposition: From a Rare Pediatric Tumor to Lifetime Risk
Published in Frontiers in oncology (21-01-2021)“…DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused by variants in the gene. The risk to present a neoplasm before the age…”
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Venetoclax plus cyclophosphamide and topotecan in heavily pre-treated relapsed metastatic neuroblastoma: a single center case series
Published in Scientific reports (07-11-2023)“…The prognosis of relapsed/refractory (R/R) neuroblastoma (NB) is dismal, calling for new therapeutic strategies. Venetoclax (VEN) is a highly selective,…”
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A case of SARS-CoV-2 Omicron reinfection resulting in a significant immunity boost in a paediatric patient affected by B-cell acute lymphoblastic leukemia
Published in BMC infectious diseases (07-03-2023)“…Since its emergence in November 2021, SARS-CoV-2 Omicron clade has quickly become dominant, due to its increased transmissibility and immune evasion. Different…”
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Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma
Published in Journal of experimental & clinical cancer research (22-10-2024)“…Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and low…”
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Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma
Published in Journal of experimental & clinical cancer research (17-11-2022)“…Abstract Background Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a…”
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Case Report: Early Association of Vemurafenib to Standard Chemotherapy in Multisystem Langerhans Cell Histiocytosis in a Newborn: Taking a Chance for a Better Outcome?
Published in Frontiers in oncology (13-12-2021)“…Langerhans cell histiocytosis (LCH) is due to aberrant monoclonal proliferation and accumulation of dendritic cells, ranging from a self-limiting local…”
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Case report: A new pathogenic variant of LRBA deficiency with a complex phenotype and Rosai-Dorfman disease
Published in Frontiers in immunology (09-12-2022)“…We reported a new pathogenic variant of LRBA deficiency with a complex phenotype-neonatal diabetes, very early-onset inflammatory bowel disease, and…”
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Case report: A safeguard in the sea of variants of uncertain significance: a case study on child with high risk neuroblastoma and acute myeloid leukemia
Published in Frontiers in oncology (08-01-2024)“…The increased availability of genetic technologies has significantly improved the detection of novel germline variants conferring a predisposition to tumor…”
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Unraveling the impact of upfront chemotherapy and proton beam therapy on treatment outcome and follow-up in central nervous system germ cell tumors: a single center experience
Published in Frontiers in oncology (04-10-2023)“…Background Germ cell tumors (GCT) account for a minority of central nervous system (CNS) malignancies, highly prevalent in adolescents and young adults…”
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Safety and Efficacy of Mek Inhibitors in the Treatment of Plexiform Neurofibromas: A Retrospective Study
Published in Cancer control (01-01-2023)“…Introduction Plexiform neurofibromas (PN) represent the main cause of morbidity in patients affected by Neurofibromatosis Type 1 (NF1). Until recently, surgery…”
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Salvage rates and prognostic factors after relapse in children and adolescents with initially localised synovial sarcoma
Published in European journal of cancer (1990) (01-12-2012)“…Abstract Background Previous studies have reported a poor outcome for synovial sarcoma patients whose tumours relapse. Methods This study analysed 44 relapsing…”
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SHH medulloblastoma and very early onset of bowel polyps in a child with PTEN hamartoma tumor syndrome
Published in Frontiers in molecular neuroscience (24-08-2023)“…Phosphatase and tensin homolog ( PTEN ) hamartoma tumor syndrome (PHTS) is a cancer predisposition syndrome characterized by an increased risk of developing…”
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The 4YouLab Model: A Dedicated-Program for Adolescents and Young Adults With Cancer in a Children’s Hospital
Published in Frontiers in oncology (01-07-2021)Get full text
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Glycopyrrolate for drooling in children with medical complexity under three years of age
Published in Italian journal of pediatrics (08-01-2022)“…The aim of the study is to determine that Glycopirrolate is safe and effective in decreasing drooling in children with medical complexity under 3 years of age…”
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Preoperative Spinal Angiography for Thoracic Neuroblastoma: Impact of Identification of the Adamkiewicz Artery on Gross Total Resection and Neurological Sequelae
Published in Children (Basel) (27-06-2023)“…Patients with thoracic neuroblastoma (TNB) are at high risk of postoperative neurologic complications due to iatrogenic lesions of the artery of Adamkiewicz…”
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Local control in metastatic neuroblastoma in children over 1 year of age
Published in BMC cancer (21-02-2015)“…Local control is always considered in metastatic neuroblastoma (NBL). The aim of this study is to evaluate the impact of radical surgery on survival in…”
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A neonatal cluster of novel coronavirus disease 2019: clinical management and considerations
Published in Italian journal of pediatrics (07-12-2020)“…Lately, one of the major clinical and public health issues has been represented by Coronavirus disease of 2019 (COVID-19) during pregnancy and the risk of…”
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Hyperinflammation in Two Severe Acute Respiratory Syndrome Coronavirus 2-Infected Adolescents Successfully Treated With the Interleukin-1 Inhibitor Anakinra and Glucocorticoids
Published in Frontiers in pediatrics (30-11-2020)“…In severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) critically ill adults, hyperinflammation plays a key role in disease progression. The…”
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