Search Results - "De Hoogt, Ronald"

Ellipsoid Segmentation Model for Analyzing Light-Attenuated 3D Confocal Image Stacks of Fluorescent Multi-Cellular Spheroids by Barbier, Michaël, Jaensch, Steffen, Cornelissen, Frans, Vidic, Suzana, Gjerde, Kjersti, de Hoogt, Ronald, Graeser, Ralph, Gustin, Emmanuel, Chong, Yolanda T

“…In oncology, two-dimensional in-vitro culture models are the standard test beds for the discovery and development of cancer treatments, but in the last…”
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Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo by Hickman, John A., Graeser, Ralph, de Hoogt, Ronald, Vidic, Suzana, Brito, Catarina, Gutekunst, Matthias, van der Kuip, Heiko, IMI PREDECT consortium

“…Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with their host. Models of human cancer in vitro, used in cancer biology and…”
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Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery by Stock, Kristin, Estrada, Marta F., Vidic, Suzana, Gjerde, Kjersti, Rudisch, Albin, Santo, Vítor E., Barbier, Michaël, Blom, Sami, Arundkar, Sharath C., Selvam, Irwin, Osswald, Annika, Stein, Yan, Gruenewald, Sylvia, Brito, Catarina, van Weerden, Wytske, Rotter, Varda, Boghaert, Erwin, Oren, Moshe, Sommergruber, Wolfgang, Chong, Yolanda, de Hoogt, Ronald, Graeser, Ralph

“…Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More…”
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Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes by Verheyen, An, Diels, Annick, Reumers, Joke, Van Hoorde, Kirsten, Van den Wyngaert, Ilse, van Outryve d’Ydewalle, Constantin, De Bondt, An, Kuijlaars, Jacobine, De Muynck, Louis, De Hoogt, Ronald, Bretteville, Alexis, Jaensch, Steffen, Buist, Arjan, Cabrera-Socorro, Alfredo, Wray, Selina, Ebneth, Andreas, Roevens, Peter, Royaux, Ines, Peeters, Pieter J.

“…Tauopathies such as frontotemporal dementia (FTD) remain incurable to date, partially due to the lack of translational in vitro disease models. The MAPT gene,…”
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Translation of a tumor microenvironment mimicking 3D tumor growth co-culture assay platform to high-content screening by Krausz, Eberhard, de Hoogt, Ronald, Gustin, Emmanuel, Cornelissen, Frans, Grand-Perret, Thierry, Janssen, Lut, Vloemans, Nele, Wuyts, Dirk, Frans, Sandy, Axel, Amy, Peeters, Pieter Johan, Hall, Brett, Cik, Miroslav

“…For drug discovery, cell-based assays are becoming increasingly complex to mimic more realistically the nature of biological processes and their…”
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Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes identified by transcriptional profiling of laser-capture microdissected endothelial and smooth muscle cells by Bökenkamp, Regina, van Brempt, Ronald, van Munsteren, Jacoba Cornelia, van den Wijngaert, Ilse, de Hoogt, Ronald, Finos, Livio, Goeman, Jelle, Groot, Adriana Cornelia Gittenberger-de, Poelmann, Robert Eugen, Blom, Nicolaas Andreas, DeRuiter, Marcus Cornelis

“…Closure of the ductus arteriosus (DA) is a crucial step in the transition from fetal to postnatal life. Patent DA is one of the most common cardiovascular…”
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Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission by Ooms, Maarten, Celen, Sofie, De Hoogt, Ronald, Lenaerts, Ilse, Liebregts, Johnny, Vanhoof, Greet, Langlois, Xavier, Postnov, Andrey, Koole, Michel, Verbruggen, Alfons, Van Laere, Koen, Bormans, Guy

“…Background Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of…”
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Alterations in the Brain–Gut Axis Underlying Visceral Chemosensitivity in Nippostrongylus brasiliensis- Infected Mice by Aerssens, Jeroen, Hillsley, Kirk, Peeters, Pieter J, de Hoogt, Ronald, Stanisz, Andrzej, Lin, Jia–Hui, Van den Wyngaert, Ilse, Göhlmann, Hinrich W, Grundy, David, Stead, Ronald H, Coulie, Bernard

“…Background & Aims: Visceral hypersensitivity, a hallmark of irritable bowel syndrome, is generally considered to be mechanosensitive in nature and mediated via…”
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An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans by De Backer, Marianne D, Nelissen, Bart, Logghe, Marc, Viaene, Jasmine, Loonen, Inge, Vandoninck, Sandy, de Hoogt, Ronald, Dewaele, Sylviane, Simons, Fermin A, Verhasselt, Peter, Vanhoof, Greet, Contreras, Roland, Luyten, Walter H.M.L

“…Converting the complete genome sequence of Candida albicans into meaningful biological information will require comprehensive screens for identifying…”
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Assessment of the Microbiota in Microdissected Tissues of Crohn's Disease Patients by De Hertogh, Gert, Lemmens, Bart, Verhasselt, Peter, de Hoogt, Ronald, Sagaert, Xavier, Joossens, Marie, Van Assche, Gert, Rutgeerts, Paul, Vermeire, Severine, Aerssens, Jeroen

“…The microbiota of the gastrointestinal tract is frequently mentioned as one of the key players in the etiopathogenesis of Crohn's disease (CD). Four hypotheses…”
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The Hepatocarcinoma Cell Line HepG2 Does Not Express a GHS-R1a-Type Ghrelin Receptor by THIELEMANS, LEEN, PEETERS, PIETER J., JONCKHEERE, HEIDI, LUYTEN, WALTER, HOOGT, RONALD DE, COULIE, BERNARD, AERSSENS, JEROEN

“…The interaction of ghrelin, a 28-residue acylated peptide, with the growth hormone secretagogue receptor 1a (GHS-R1a) has been studied mostly in cells…”
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PCR- and ligation-mediated synthesis of split-marker cassettes with long flanking homology regions for gene disruption in Candida albicans by de Hoogt, R, Luyten, W H, Contreras, R, De Backer, M D

“…Because Candida albicans is a diploid organism, two consecutive steps of gene disruption are required to generate a gene knock-out. The same marker (URA3) is…”
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Single allele knock-out of Candida albicans CGT1 leads to unexpected resistance to hygromycin B and elevated temperature by De Backer, Marianne D, de Hoogt, Ronald A, Froyen, Guy, Odds, Frank C, Simons, Fermin, Contreras, Roland, Luyten, Walter H. M. L

“…Department of Advanced Bio-Technologies 1 and Department of Bacteriology and Mycology 2 , Janssen Research Foundation, Turnhoutseweg 30, B2340 Beerse, Belgium…”
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Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2 by Van Kolen, Kristof, Verstraeten, Karin, Royaux, Ines, De Hoogt, Ronald, Gutknecht, Eric, Peeters, Pieter J.

“…CRF-induced ERK phosphorylation has been shown to be an important mechanism underlying expression of pro-opiomelanocortin, a key precursor molecule in the…”
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Alterations in Mucosal Immunity Identified in the Colon of Patients With Irritable Bowel Syndrome by Aerssens, Jeroen, Camilleri, Michael, Talloen, Willem, Thielemans, Leen, Göhlmann, Hinrich W.H, Van den Wyngaert, Ilse, Thielemans, Theo, De Hoogt, Ronald, Andrews, Christopher N, Bharucha, Adil E, Carlson, Paula J, Busciglio, Irene, Burton, Duane D, Smyrk, Thomas, Urrutia, Raul, Coulie, Bernard

“…Background & Aims: Irritable bowel syndrome (IBS) has been associated with mucosal dysfunction, mild inflammation, and altered colonic bacteria. We used…”
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Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project by de Hoogt, Ronald, Estrada, Marta F., Vidic, Suzana, Davies, Emma J., Osswald, Annika, Barbier, Michael, Santo, Vítor E., Gjerde, Kjersti, van Zoggel, Hanneke J. A. A., Blom, Sami, Dong, Meng, Närhi, Katja, Boghaert, Erwin, Brito, Catarina, Chong, Yolanda, Sommergruber, Wolfgang, van der Kuip, Heiko, van Weerden, Wytske M., Verschuren, Emmy W., Hickman, John, Graeser, Ralph

“…Two-dimensional (2D) culture of cancer cells in vitro does not recapitulate the three-dimensional (3D) architecture, heterogeneity and complexity of human…”
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Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes by Verheyen, An, Diels, Annick, Reumers, Joke, Van Hoorde, Kirsten, Van den Wyngaert, Ilse, van Outryve d’Ydewalle, Constantin, De Bondt, An, Kuijlaars, Jacobine, De Muynck, Louis, De Hoogt, Ronald, Bretteville, Alexis, Jaensch, Steffen, Buist, Arjan, Cabrera-Socorro, Alfredo, Wray, Selina, Ebneth, Andreas, Roevens, Peter, Royaux, Ines, Peeters, Pieter J.

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Abstract 2023: Complex in vitro and in vivo prostate cancer models for the PREDECT consortium by Vidic, Suzana, Esser, Norbert, Hoogt, Ronald de, Verberne, Ingrid, Kogan-Sakin, Ira, Stein, Yan, Rotter, Varda, Barbier, Michael, Chong, Yolanda, Breucker, Sabine D., Smans, Karine, Akerfelt, Malin, Nees, Matthias, King, Peter, Hickson, Ian, Weerden, Wytske van, Graeser, Ralph

“…The failure of many drugs in the clinic - drugs proven to be active in pre-clinical assays - has raised question marks on the predictive power of these models,…”
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Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution by Piccart, Elisabeth, Gantois, Ilse, Laeremans, Annelies, de Hoogt, Ronald, Meert, Theo, Vanhoof, Greet, Arckens, Lutgarde, D’Hooge, Rudi

“…► PDE10A knockout mice show impaired appetitive and aversive conditioning. ► PDE10A knockout mice show spatial learning deficits in the Morris water maze. ►…”
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Abstract 1698: Systems pathology for characterization of cancer model systems in a multicenter IMI-PREDECT project by Blom, Sami, Wang, Yinhai, Metsalu, Tauno, Vesterinen, Tiina, Pellinen, Teijo, Grote, Anne, Linder, Nina, Säilä, Jenni, Välimäki, Katja, Kovanen, Ruusu-Maria, Monni, Outi, Kovanen, Panu, Davies, Emma, Stock, Kristin, Estrada, Marta, Sflomos, Georgios, Grünewald, Sylvia, Brito, Catarina, Schüler, Julia, de Hoogt, Ronald, Brisken, Cathrin, van der Kuip, Heiko, van Weerden, Wytske, Barry, Simon, Sommergruber, Wolgang, Anderson, Elizabeth, Nees, Matthias, Klefström, Juha, Vilo, Jaak, Verschuren, Emmy, Graeser, Ralph, Hickman, John, Lundin, Johan, Kallioniemi, Olli

“…Despite of our increased understanding of cancer biology, the majority of anti-cancer therapies fail at late-stage clinical trials. Thus, there is an urgent…”
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