Search Results - "De Gunzburg, Jean"

Oral DAV131, a Charcoal-Based Adsorbent, Inhibits Intestinal Colonization by β-Lactam-Resistant Klebsiella pneumoniae in Cefotaxime-Treated Mice by Grall, Nathalie, Massias, Laurent, Nguyen, Thu Thuy, Sayah-Jeanne, Sakina, Ducrot, Nicolas, Chachaty, Elisabeth, de Gunzburg, Jean, Andremont, Antoine

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278 Systematic review and meta-analysis evaluating the impact of antibiotic use on clinical outcomes of non-small-cell lung cancer patients treated with immune checkpoint inhibitors by Crespin, Athéna, Bandinelli, Pierre-Alain, Bescop, Clément Le, Buffet, Renaud, Gunzburg, Jean De, Vitry, Fabien, Zalcman, Gérard, Cervesi, Julie

“…BackgroundIn recent years, the gut microbiome has increasingly emerged as influencing the response to immune checkpoint inhibitors (ICIs).1–3 Antibiotic (ABX)…”
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671 Update of a systematic review and meta-analysis studying the association between antibiotic use and clinical outcomes of non-small-cell lung cancer patients treated with immune checkpoint inhibitors by Bandinelli, Pierre-Alain, Cervesi, Julie, Bescop, Clément Le, Buffet, Renaud, Gunzburg, Jean De, Zalcman, Gérard

“…BackgroundImmune checkpoint inhibitors (ICIs) have been shown to improve patients‘ clinical outcomes in a variety of cancers, but with variable efficacy. Prior…”
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NSCLC Immunotherapy Efficacy and Antibiotic Use: A Systematic Review and Meta-Analysis by Lurienne, Lise, Cervesi, Julie, Duhalde, Lola, de Gunzburg, Jean, Andremont, Antoine, Zalcman, Gérard, Buffet, Renaud, Bandinelli, Pierre-Alain

“…Immune checkpoint inhibitors (ICIs) have dramatically improved patient outcomes in a variety of tumor types, but with variable efficacy. Recent research has…”
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Spare and repair the gut microbiota from antibiotic-induced dysbiosis: state-of-the-art by Andremont, Antoine, Cervesi, Julie, Bandinelli, Pierre-Alain, Vitry, Fabien, de Gunzburg, Jean

“…•The gut microbiota is regarded nowadays as a key component for human health.•Dysbiosis is an unrecognized disease whose consequences just begin to be…”
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Protection of the Human Gut Microbiome From Antibiotics by de Gunzburg, Jean, Ghozlane, Amine, Ducher, Annie, Le Chatelier, Emmanuelle, Duval, Xavier, Ruppé, Etienne, Armand-Lefevre, Laurence, Sablier-Gallis, Frédérique, Burdet, Charles, Alavoine, Loubna, Chachaty, Elisabeth, Augustin, Violaine, Varastet, Marina, Levenez, Florence, Kennedy, Sean, Pons, Nicolas, Mentré, France, Andremont, Antoine

“…In a phase 1 clinical study, coadministration of the adsorbent-based DAV132 product together with the fluoroquinolone antibiotic moxifloxacin, while not…”
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Identification of new transformation products during enzymatic treatment of tetracycline and erythromycin antibiotics at laboratory scale by an on-line turbulent flow liquid-chromatography coupled to a high resolution mass spectrometer LTQ-Orbitrap by Llorca, Marta, Rodríguez-Mozaz, Sara, Couillerot, Olivier, Panigoni, Karine, de Gunzburg, Jean, Bayer, Sally, Czaja, Rico, Barceló, Damià

“…•Development of a fast and sensitive method for the analysis of unknown compounds in waters.•On-line turbulent flow chromatography coupled to a high resolution…”
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The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers by Messaoudene, Meriem, Ferreira, Stéphanie, Saint-Lu, Nathalie, Ponce, Mayra, Truntzer, Caroline, Boidot, Romain, Le Bescop, Clément, Loppinet, Thomas, Corbel, Tanguy, Féger, Céline, Bertrand, Karine, Elkrief, Arielle, Isaksen, Morten, Vitry, Fabien, Sablier-Gallis, Frédérique, Andremont, Antoine, Bod, Lloyd, Ghiringhelli, François, de Gunzburg, Jean, Routy, Bertrand

“…The deleterious impact of antibiotics (ATB) on the microbiome negatively influences immune checkpoint inhibitors (ICI) response in patients with cancer. We…”
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A systematic review and meta-analysis evaluating the impact of antibiotic use on the clinical outcomes of cancer patients treated with immune checkpoint inhibitors by Crespin, Athéna, Le Bescop, Clément, de Gunzburg, Jean, Vitry, Fabien, Zalcman, Gérard, Cervesi, Julie, Bandinelli, Pierre-Alain

“…Immune checkpoint inhibitors (ICIs) have considerably improved patient outcomes in various cancer types, but their efficacy remains poorly predictable among…”
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Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection by Burdet, Charles, Sayah-Jeanne, Sakina, Nguyen, Thu Thuy, Hugon, Perrine, Sablier-Gallis, Frédérique, Saint-Lu, Nathalie, Corbel, Tanguy, Ferreira, Stéphanie, Pulse, Mark, Weiss, William, Andremont, Antoine, Mentré, France, de Gunzburg, Jean

“…Antibiotic disruption of the intestinal microbiota favors colonization by Using a charcoal-based adsorbent to decrease intestinal antibiotic concentrations, we…”
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Mathematical modeling of bacterial kinetics to predict the impact of antibiotic colonic exposure and treatment duration on the amount of resistant enterobacteria excreted by Nguyen, Thu Thuy, Guedj, Jeremie, Chachaty, Elisabeth, de Gunzburg, Jean, Andremont, Antoine, Mentré, France

“…Fecal excretion of antibiotics and resistant bacteria in the environment are major public health threats associated with extensive farming and modern medical…”
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Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis by Dao, Vi Thuy, Dupuy, Aurélien Guy, Gavet, Olivier, Caron, Emmanuelle, de Gunzburg, Jean

“…At the onset of mitosis, most adherent cells undergo cell retraction characterised by the disassembly of focal adhesions and actin stress fibres. Mitosis takes…”
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Correlation between Fecal Concentrations of Ciprofloxacin and Fecal Counts of Resistant Enterobacteriaceae in Piglets Treated with Ciprofloxacin: toward New Means To Control the Spread of Resistance? by NGUYEN, Thu Thuy, CHACHATY, Elisabeth, HUY, Clarisse, CAMBIER, Carole, DE GUNZBURG, Jean, MENTRE, France, ANDREMONT, Antoine

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Prevalence of Beta-Lactam and Quinolone/Fluoroquinolone Resistance in Enterobacteriaceae From Dogs in France and Spain—Characterization of ESBL/pAmpC Isolates, Genes, and Conjugative Plasmids by Dupouy, Véronique, Abdelli, Mouni, Moyano, Gabriel, Arpaillange, Nathalie, Bibbal, Delphine, Cadiergues, Marie-Christine, Lopez-Pulin, Diego, Sayah-Jeanne, Sakina, de Gunzburg, Jean, Saint-Lu, Nathalie, Gonzalez-Zorn, Bruno, Andremont, Antoine, Bousquet-Mélou, Alain

“…Quantitative data on fecal shedding of antimicrobial-resistant bacteria are crucial to assess the risk of ansmission from dogs to humans. Our first objective…”
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Dissecting Activation of the PAK1 Kinase at Protrusions in Living Cells by Parrini, Maria Carla, Camonis, Jacques, Matsuda, Michiyuki, de Gunzburg, Jean

“…The p21-activated kinase (PAK) 1 kinase, an effector of the Cdc42 and Rac1 GTPases, regulates cell protrusions and motility by controlling actin and adhesion…”
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Biochemical and Structural Characterization of the Gem GTPase by Splingard, Anne, Ménétrey, Julie, Perderiset, Mylène, Cicolari, Jérome, Regazzoni, Karine, Hamoudi, Fatima, Cabanié, Lucien, El Marjou, Ahmed, Wells, Amber, Houdusse, Anne, de Gunzburg, Jean

“…RGK proteins, encompassing Rad, Gem, Rem1, and Rem2, constitute an intriguing branch of the Ras superfamily; their expression is regulated at the transcription…”
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Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking by Leprince, Corinne, Le Scolan, Erwan, Meunier, Brigitte, Fraisier, Vincent, Brandon, Nathalie, De Gunzburg, Jean, Camonis, Jacques

“…Endocytosis is a regulated physiological process by which membrane receptors and their extracellular ligands are internalized. After internalization, they…”
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Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras–Raf-1- and Rap1–B-Raf-Dependent Pathways by Garcia, Josefina, de Gunzburg, Jean, Eychène, Alain, Gisselbrecht, Sylvie, Porteu, Françoise

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A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases by Aresta, Sandra, de Tand-Heim, Marie-France, Béranger, Florence, de Gunzburg, Jean

“…Gem is a Ras-related protein whose expression is induced in several cell types upon activation by extracellular stimuli. With the aim of isolating the cellular…”
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Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac by DUPUY, Aurélien G, L'HOSTE, Sébastien, CHERFILS, Jacqueline, CAMONIS, Jacques, GAUDRIAULT, Georges, DE GUNZBURG, Jean

“…Rap1 is a Ras-related GTPase that is principally involved in integrin- and E-cadherin-mediated adhesion. Rap1 is transiently activated in response to many…”
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