Search Results - "De Gruijl, F"

The consequences for human health of stratospheric ozone depletion in association with other environmental factors by Lucas, R M, Norval, M, Neale, R E, Young, A R, de Gruijl, F R, Takizawa, Y, van der Leun, J C

“…Due to the implementation of the Montreal Protocol, which has limited, and is now probably reversing, the depletion of the stratospheric ozone layer, only…”
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Everyday sunscreen use may compromise vitamin D in temperate climes by de Gruijl, F.R., Webb, A.R., Rhodes, L.E.

“…Linked Article: Passeron et al. Br J Dermatol 2019; 181:916–31…”
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Skin cancer and solar UV radiation by de Gruijl, F.R.

“…Ultraviolet (UV) radiation in sunlight is the most prominent and ubiquitous physical carcinogen in our natural environment. It is highly genotoxic but does not…”
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UVA radiation causes DNA strand breaks, chromosomal aberrations and tumorigenic transformation in HaCaT skin keratinocytes by Wischermann, K, Popp, S, Moshir, S, Scharfetter-Kochanek, K, Wlaschek, M, de Gruijl, F, Hartschuh, W, Greinert, R, Volkmer, B, Faust, A, Rapp, A, Schmezer, P, Boukamp, P

“…The role of UVA-radiation—the major fraction in sunlight—in human skin carcinogenesis is still elusive. We here report that different UVA exposure regime (4 ×…”
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Predictions of skin cancer incidence in the Netherlands up to 2015 by De Vries, E., Van De Poll-Franse, L.V., Louwman, W.J., De Gruijl, F.R., Coebergh, J.W.W.

“…Summary  Background  Skin cancer is an important, growing public health problem among white caucasians, causing a heavy burden on dermatologists and general…”
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Molecular and Immunologic Mechanisms of Cancer Pathogenesis in Solid Organ Transplant Recipients by Martinez, O. M., De Gruijl, F. R.

“…The increased risk for the development of malignancies in transplant recipients is generally attributed to the debilitated immune system that results from…”
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UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis by REBEL, H. G, BODMANN, C. A, DE GLIND, G. C. Van, DE GRUIJL, F. R

“…Chronic ultraviolet (UV) exposure induces clones of cells overexpressing mutant p53 in the interfollicular (IF) epidermis and subsequently squamous cell…”
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Previtamin D action spectrum: Challenging CIE towards a standard by Webb, AR, Terenetskaya, IP, Holick, MF, van Dijk, A, McKenzie, RL, Lucas, RM, Young, AR, Philipsen, PA, de Gruijl, FR

“…In 2006, CIE published a technical report on an action spectrum for the production of previtamin D3 in human skin. CIE procedure is to publish guidelines…”
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Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset by Voskamp, P., Bodmann, C.A., Rebel, H.G., Koehl, G.E., Tensen, C.P., Bouwes Bavinck, J.N., El Ghalbzouri, A., Van Kranen, H.J., Willemze, R., Geissler, E.K., De Gruijl, F.R.

“…Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ transplant recipients in that it may lower their cancer risk. In…”
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Early and late effects of the immunosuppressants rapamycin and mycophenolate mofetil on UV carcinogenesis by de Gruijl, F.R., Koehl, G.E., Voskamp, P., Strik, A., Rebel, H.G., Gaumann, A., de Fijter, J.W., Tensen, C.P., Bavinck, J.N. Bouwes, Geissler, E.K.

“…Increased skin cancer risk in organ transplant recipients has been experimentally emulated with enhanced UV carcinogenesis from administering conventional…”
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Normalized ultraviolet (UV) induction of Langerhans cell depletion and neutrophil infiltrates after artificial UVB hardening of patients with polymorphic light eruption by Janssens, A.S., Pavel, S., Out-Luiting, J.J., Willemze, R., De Gruijl, F.R.

“…Summary Background  Ultraviolet (UV) B hardening has been widely used as a prophylactic treatment in patients with polymorphic light eruption (PLE). Recent…”
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The human health effects of ozone depletion and interactions with climate change by Norval, M, Lucas, R M, Cullen, A P, de Gruijl, F R, Longstreth, J, Takizawa, Y, van der Leun, J C

“…Depletion of the stratospheric ozone layer has led to increased solar UV-B radiation (280-315 nm) at the surface of the Earth. This change is likely to have…”
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Estimates of ozone depletion and skin cancer incidence to examine the Vienna Convention achievements by Slaper, Harry, Velders, Guus J. M, Daniel, John S, de Gruijl, Frank R, van der Leun, Jan C

“…Depletion of the ozone layer has been observed on a global scale, and is probably related to halocarbon emissions. Ozone depletion increases the biologically…”
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Concurrent beneficial (vitamin D production) and hazardous (cutaneous DNA damage) impact of repeated low-level summer sunlight exposures by Felton, S.J., Cooke, M.S., Kift, R., Berry, J.L., Webb, A.R., Lam, P.M.W., de Gruijl, F.R., Vail, A., Rhodes, L.E.

“…Summary Background The concurrent impact of repeated low‐level summer sunlight exposures on vitamin D production and cutaneous DNA damage, potentially leading…”
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Phototherapy in the perspective of the chronicity of psoriasis by Kerkhof, P.C.M., Gruijl, F.R.

“…According to the guidelines for the treatment of psoriasis, phototherapy is given in courses of UVB exposure starting at 50–70% of the minimal erythema dose,…”
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Health risks by Longstreth, J., de Gruijl, F.R., Kripke, M.L., Abseck, S., Arnold, F., Slaper, H.I., Velders, G., Takizawa, Y., van der Leun, J.C.

“…The health risks associated with ozone depletion will principally be those due to increased ultraviolet B (UV-B) radiation in the environment, i.e., increased…”
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Predicted increased risk of squamous cell carcinoma induction associated with sunbed exposure habits by Tierney, P., de Gruijl, F.R., Ibbotson, S., Moseley, H.

“…Summary Background Solar ultraviolet radiation (UVR) is recognized as the principal environmental cause of skin cancer. In particular, the risk of induction of…”
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Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema by BERG, R. J. W, RUVEN, H. J. T, SANDS, A. T, DE GRUIJL, F. R, MULLENDERS, L. H. F

“…It is generally presumed that xeroderma pigmentosum (XP) patients are extremely sensitive to developing UV erythema, and that they have a more than 1000-fold…”
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UVB exposure‐induced systemic modulation of Th1‐ and Th2‐mediated immune responses by Garssen, J, Vandebriel, R J, De Gruijl, F R, Wolvers, D A, Van Dijk, M, Fluitman, A, Van Loveren, H

“…Exposure to ultraviolet light, especially UVB wavelengths, can impair immune responses in animals and humans. It is remarkable that this immunomodulation is…”
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Estimate of the wavelength dependency of ultraviolet carcinogenesis in humans and its relevance to the risk assessment of a stratospheric ozone depletion by de Gruijl, F R, Van der Leun, J C

“…The wavelength dependency of carcinogenesis is an important factor in risk assessments pertaining to sources of ultraviolet radiation, the most important of…”
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