Search Results - "De Groot, Rolf P."

The role of STATs in myeloid differentiation and leukemia by Coffer, P J, Koenderman, L, de Groot, R P

“…Myeloid differentiation is a highly regulated process governed by various cytokines, such as EPO, TPO, G-CSF, IL-3, IL-5 and GM-CSF. These cytokines act in…”
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Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation by Turkson, James, Bowman, Tammy, Garcia, Roy, Caldenhoven, Eric, De Groot, Rolf P., Jove, Richard

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor by DIJKERS, P. F, VAN DIJK, T. B, DE GROOT, R. P, RAAIJMAKERS, J. A, LAMMERS, J.-W. J, KOENDERMAN, L, COFFER, P. J

“…Interleukin (IL)-3, IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) regulate proliferation, differentiation and apoptosis of target cells…”
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Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family by de Groot, Rolf P., Coffer, Paul J., Koenderman, Leo

“…The receptors for the Il-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric complex of a cytokine-specific α chain and a common β chain (βc)…”
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STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells by de Groot, Rolf P., Raaijmakers, Jan A.M., Lammers, Jan-Willem J., Jove, Richard, Koenderman, Leo

“…Signal transducers and activators of transcription (STATs) belong to a family of transcription factors that were originally identified as mediators of…”
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Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues by Emilsson, Valur, Arch, Jonathan R.S., de Groot, Rolf P., Lister, Carolyn A., Cawthorne, Michael A.

“…Leptin concentrations are elevated in the majority of obese individuals raising the possibility that leptin resistance contributes to their obesity. Peripheral…”
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Microgravity decreases c-fos induction and serum response element activity by DE GROOT, R. P, RIJKEN, P. J, DEN HERTOG, J, BOONSTRA, J, VERKLEIJ, A. J, DE LAAT, S. W, KRUIJER, W

“…Several studies have shown that altered gravity conditions influence mammalian cell growth and differentiation. The molecular mechanisms underlying these…”
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Lineage-specific activation of STAT3 by interferon-gamma in human neutrophils by Caldenhoven, Eric, Buitenhuis, Miranda, Djk, Thamar B., Raaijmakers, Jan A. M., Lammers, Jan‐Willem J., Koenderman, Leo, Groot, Rolf P.

“…Binding of interferon‐γ (IFN‐γ) to its heterodimeric receptor induces activation of the tyrosine kinases JAK1 and JAK2 followed by tyrosine phosphorylation of…”
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Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 (∗) by Caldenhoven, Eric, van Dijk, Thamar, Raaijmakers, Jan A.M., Lammers, Jan-Willem J., Koenderman, Leo, de Groot, Rolf P.

“…The receptor for interleukin-5 (IL-5R) is composed of a unique α chain (IL-5Rα) expressed on eosinophils and basophils, associated with a βc subunit, which is…”
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Differential Activation of Functionally Distinct STAT5 Proteins by IL‐5 and GM‐CSF During Eosinophil and Neutrophil Differentiation from Human CD34+ Hematopoietic Stem Cells by Caldenhoven, Eric, van Dijk, Thamar B., Tijmensen, Annelien, Raaijmakers, Jan A. M., Lammers, Jan‐Willem J., Koenderman, Leo, de Groot, Rolf P.

“…Interleukin‐5 (IL‐5) and granulocyte macrophage‐colony stimulating factor (GM‐CSF) are important cytokines for the proliferation, differentiation, and…”
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C/EBP regulates the promoter of the eosinophil-derived neurotoxin/RNS2 gene in human eosinophilic cells by Baltus, Belinda, Buitenhuis, Miranda, Dijk, Thamar B., Vinson, Charles, Raaijmakers, Jan A. M., Lammers, Jan‐Willem J., Koenderman, Leo, Groot, Rolf P.

“…The eosinophil‐derived neurotoxin (EDN), a member of the mammalian ribonuclease family, is found in the large specific granules of human eosinophilic…”
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Activation of 12-O-Tetradecanoylphorbol-13-acetate Response Element- and Dyad Symmetry Element-dependent Transcription by Interleukin-5 Is Mediated by Jun N-terminal Kinase/Stress-activated Protein Kinase Kinases by de Groot, Rolf P., van Dijk, Thamar B., Caldenhoven, Eric, Coffer, Paul J., Raaijmakers, JanA.M., Lammers, Jan-Willem J., Koenderman, Leo

“…Interleukin-5 (IL-5) is one of the major regulators of eosinophilic granulocytes in vivo. IL-5 exerts its pleiotropic effects by binding to the IL-5 receptor,…”
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Multiple tyrosine residues in the intracellular domain of the common β subunit of the interleukin 5 receptor are involved in activation of STAT5 by van Dijk, Thamar B, Caldenhoven, Eric, Raaijmakers, Jan A.M, Lammers, Jan-Willem J, Koenderman, Leo, de Groot, Rolf P

“…In contrast to the general model of cytokine-induced JAK/STAT signaling, tyrosine phosphorylation of the IL-5R β chain seems to be dispensable for STAT…”
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An AP-1 site in the promoter of the human IL-5Rα gene is necessary for promoter activity in eosinophilic HL60 cells by Baltus, Belinda, van Dijk, Thamar B, Caldenhoven, Eric, Zanders, Ed, Raaijmakers, Jan A.M, Lammers, Jan-Willem J, Koenderman, Leo, de Groot, Rolf P

“…Interleukin-5 (IL-5) plays a crucial role in the proliferation, differentiation and activation of eosinophils. The IL-5 receptor is composed of an…”
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Inhibition of EGF-induced signal transduction by microgravity is independent of EGF receptor redistribution in the plasma membrane of human A431 cells by Rijken, P J, de Groot, R P, van Belzen, N, de Laat, S W, Boonstra, J, Verkleij, A J

“…Epidermal growth factor (EGF)-induced c-fos and c-jun expression is strongly suppressed in microgravity. We investigate here whether this is due to inhibition…”
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STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription by Caldenhoven, Eric, van Dijk, Thamar B., Solari, Roberto, Armstrong, John, Raaijmakers, Jan A.M., Lammers, Jan-Willem J., Koenderman, Leo, de Groot, Rolf P.

“…The 89-kDa STAT3 protein is a latent transcription factor which is activated in response to cytokines (interleukin (IL)-5 and -6) and growth factors (epidermal…”
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Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression by de Groot, R P, Ballou, L M, Sassone-Corsi, P

“…Activation of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements (CREs). Nuclear factor…”
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Multiple and cooperative phosphorylation events regulate the CREM activator function by Groot, R.P., Hertog, J., Vandenheede, J.R., Goris, J., Sassone‐Corsi, P.

“…Phosphorylation is one of the major mechanisms by which the activity of transcription factors can be regulated. We have investigated the role of…”
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STAT5-Dependent CyclinD1 and Bcl-xL Expression in Bcr-Abl-Transformed Cells by de Groot, Rolf P., Raaijmakers, Jan A.M., Lammers, Jan-Willem J., Koenderman, Leo

“…Signal transducers and activators of transcription (STATs) are a family of transcription factors that were originally identified as mediators of…”
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Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy by de Groot, R P, Auwerx, J, Bourouis, M, Sassone-Corsi, P

“…Transcription factor AP-1 is constituted by the products of the various fos and jun genes. AP-1 activity is modulated by second messengers and appears to…”
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