Search Results - "De Gregorio, Ennio"

Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge by Magini, Diletta, Giovani, Cinzia, Mangiavacchi, Simona, Maccari, Silvia, Cecchi, Raffaella, Ulmer, Jeffrey B, De Gregorio, Ennio, Geall, Andrew J, Brazzoli, Michela, Bertholet, Sylvie

“…Current hemagglutinin (HA)-based seasonal influenza vaccines induce vaccine strain-specific neutralizing antibodies that usually fail to provide protection…”
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Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake by Liang, Frank, Lindgren, Gustaf, Sandgren, Kerrie J, Thompson, Elizabeth A, Francica, Joseph R, Seubert, Anja, De Gregorio, Ennio, Barnett, Susan, O'Hagan, Derek T, Sullivan, Nancy J, Koup, Richard A, Seder, Robert A, Loré, Karin

“…The innate immune mechanisms by which adjuvants enhance the potency and protection of vaccine-induced adaptive immunity are largely unknown. We introduce a…”
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From empiricism to rational design: a personal perspective of the evolution of vaccine development by De Gregorio, Ennio, Rappuoli, Rino

“…The technological revolution in vaccination — from the empirical approach pioneered by Jenner and Pasteur to the recent developments in structural and reverse…”
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Vaccines for the 21st century by Delany, Isabel, Rappuoli, Rino, De Gregorio, Ennio

“…In the last century, vaccination has been the most effective medical intervention to reduce death and morbidity caused by infectious diseases. It is believed…”
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Technologies to address antimicrobial resistance by Baker, Stephen J., Payne, David J., Rappuoli, Rino, De Gregorio, Ennio

“…Bacterial infections have been traditionally controlled by antibiotics and vaccines, and these approaches have greatly improved health and longevity. However,…”
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Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants by Maisonneuve, Charles, Bertholet, Sylvie, Philpott, Dana J., De Gregorio, Ennio

“…Innate immunity confers an immediate nonspecific mechanism of microbial recognition through germ line-encoded pattern recognition receptors (PRRs). Of these,…”
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Vaccines, new opportunities for a new society by Rappuoli, Rino, Pizza, Mariagrazia, Del Giudice, Giuseppe, De Gregorio, Ennio

“…Vaccination is the most effective medical intervention ever introduced and, together with clean water and sanitation, it has eliminated a large part of the…”
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Vaccines for the twenty-first century society by Rappuoli, Rino, Mandl, Christian W., Black, Steven, De Gregorio, Ennio

“…The childhood vaccination campaigns of the twentieth century represent one of the great success stories of modern medicine. But are we yet to realize the full…”
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Vaccinology in the post−COVID-19 era by Rappuoli, Rino, De Gregorio, Ennio, Del Giudice, Giuseppe, Phogat, Sanjay, Pecetta, Simone, Pizza, Mariagrazia, Hanon, Emmanuel

“…The COVID-19 pandemic is a shocking reminder of how our world would look in the absence of vaccination. Fortunately, new technologies, the pace of…”
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Alum adjuvanticity: Unraveling a century old mystery by De Gregorio, Ennio, Tritto, Elaine, Rappuoli, Rino

“…The development of vaccine adjuvants for human use has been one of the slowest processes in the history of medicine. For almost one century, aluminium…”
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Mechanism of action of licensed vaccine adjuvants by Tritto, Elaine, Mosca, Flaviana, De Gregorio, Ennio

“…Abstract Despite the fact that alum and oil-in-water emulsions have been used for decades as human vaccine adjuvants in a large number of individuals, their…”
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Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin by Brazzoli, Michela, Magini, Diletta, Bonci, Alessandra, Buccato, Scilla, Giovani, Cinzia, Kratzer, Roland, Zurli, Vanessa, Mangiavacchi, Simona, Casini, Daniele, Brito, Luis M, De Gregorio, Ennio, Mason, Peter W, Ulmer, Jeffrey B, Geall, Andrew J, Bertholet, Sylvie

“…Seasonal influenza is a vaccine-preventable disease that remains a major health problem worldwide, especially in immunocompromised populations. The impact of…”
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Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens by Knudsen, Niels Peter H., Olsen, Anja, Buonsanti, Cecilia, Follmann, Frank, Zhang, Yuan, Coler, Rhea N., Fox, Christopher B., Meinke, Andreas, D´Oro, Ugo, Casini, Daniele, Bonci, Alessandra, Billeskov, Rolf, De Gregorio, Ennio, Rappuoli, Rino, Harandi, Ali M., Andersen, Peter, Agger, Else Marie

“…The majority of vaccine candidates in clinical development are highly purified proteins and peptides relying on adjuvants to enhance and/or direct immune…”
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The path to a successful vaccine adjuvant – ‘The long and winding road’ by O’Hagan, Derek T., De Gregorio, Ennio

“…New generation vaccines will increasingly comprise highly purified recombinant proteins. Unfortunately, these antigens are often poorly immunogenic. Therefore,…”
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adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination by Vono, Maria, Taccone, Marianna, Caccin, Paola, Gallotta, Marilena, Donvito, Giovanna, Falzoni, Simonetta, Palmieri, Emiliano, Pallaoro, Michele, Rappuoli, Rino, Di Virgilio, Francesco, De Gregorio, Ennio, Montecucco, Cesare, Seubert, Anja

“…Vaccines are the most effective agents to control infections. In addition to the pathogen antigens, vaccines contain adjuvants that are used to enhance…”
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Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus by Bagnoli, Fabio, Fontana, Maria Rita, Soldaini, Elisabetta, Mishra, Ravi P N, Fiaschi, Luigi, Cartocci, Elena, Nardi-Dei, Vincenzo, Ruggiero, Paolo, Nosari, Sarah, De Falco, Maria Grazia, Lofano, Giuseppe, Marchi, Sara, Galletti, Bruno, Mariotti, Paolo, Bacconi, Marta, Torre, Antonina, Maccari, Silvia, Scarselli, Maria, Rinaudo, C Daniela, Inoshima, Naoko, Savino, Silvana, Mori, Elena, Rossi-Paccani, Silvia, Baudner, Barbara, Pallaoro, Michele, Swennen, Erwin, Petracca, Roberto, Brettoni, Cecilia, Liberatori, Sabrina, Norais, Nathalie, Monaci, Elisabetta, Bubeck Wardenburg, Juliane, Schneewind, Olaf, O'Hagan, Derek T, Valiante, Nicholas M, Bensi, Giuliano, Bertholet, Sylvie, De Gregorio, Ennio, Rappuoli, Rino, Grandi, Guido

“…Significance Staphylococcus aureus is a human pathogen causing life-threatening infections. The high incidence of methicillin-resistant S. aureus isolates…”
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The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect by Calabro, Samuele, Tritto, Elaine, Pezzotti, Annamaria, Taccone, Marianna, Muzzi, Alessandro, Bertholet, Sylvie, De Gregorio, Ennio, O’Hagan, Derek T, Baudner, Barbara, Seubert, Anja

“…Highlights • We dissect the mechanism of MF59, an adjuvant used in human vaccines. • We set to identify its putative adjuvant-active ingredient(s). • Span85…”
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MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action by Caproni, Elena, Tritto, Elaine, Cortese, Mario, Muzzi, Alessandro, Mosca, Flaviana, Monaci, Elisabetta, Baudner, Barbara, Seubert, Anja, De Gregorio, Ennio

“…The innate immune pathways induced by adjuvants required to increase adaptive responses to influenza subunit vaccines are not well characterized. We profiled…”
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Rational design of small molecules as vaccine adjuvants by Wu, Tom Y-H, Singh, Manmohan, Miller, Andrew T, De Gregorio, Ennio, Doro, Francesco, D'Oro, Ugo, Skibinski, David A G, Mbow, M Lamine, Bufali, Simone, Herman, Ann E, Cortez, Alex, Li, Yongkai, Nayak, Bishnu P, Tritto, Elaine, Filippi, Christophe M, Otten, Gillis R, Brito, Luis A, Monaci, Elisabetta, Li, Chun, Aprea, Susanna, Valentini, Sara, Calabrό, Samuele, Laera, Donatello, Brunelli, Brunella, Caproni, Elena, Malyala, Padma, Panchal, Rekha G, Warren, Travis K, Bavari, Sina, O'Hagan, Derek T, Cooke, Michael P, Valiante, Nicholas M

“…Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major…”
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Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells by Cioncada, Rossella, Maddaluno, Marcella, Vo, Hoa Thi My, Woodruff, Matthew, Tavarini, Simona, Sammicheli, Chiara, Tortoli, Marco, Pezzicoli, Alfredo, De Gregorio, Ennio, Carroll, Michael C, D'Oro, Ugo, Piccioli, Diego

“…MF59 is an oil-in-water emulsion adjuvant approved for human influenza vaccination in European Union. The mode of action of MF59 is not fully elucidated yet,…”
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