Search Results - "De Graan, P N"

Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy by PROPER, E. A, HOOGLAND, G, DE GRAAN, P. N. E, KAPPEN, S. M, JANSEN, G. H, RENSEN, M. G. A, SCHRAMA, L. H, VAN VEELEN, C. W. M, VAN RIJEN, P. C, VAN NIEUWENHUIZEN, O, GISPEN, W. H

“…In patients suffering from temporal lobe epilepsy (TLE), increased extracellular glutamate levels in the epileptogenic hippocampus both during and after…”
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Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms by HOL, E. M, ROELOFS, R. F, MORAAL, E, SONNEMANS, M. A. F, SLUIJS, J. A, PROPER, E. A, DE GRAAN, P. N. E, FISCHER, D. F, VAN LEEUWEN, F. W

“…Glial fibrillary acidic protein (GFAP) is considered to be a highly specific marker for glia. Here, we report on the expression of GFAP in neurons in the human…”
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The chemokine CCL2 modulates Ca2+ dynamics and electrophysiological properties of cultured cerebellar Purkinje neurons by Van Gassen, K. L. I., Netzeband, J. G., De Graan, P. N. E., Gruol, D. L.

“…The chemokine CCL2 is produced at high levels in the central nervous system (CNS) during infection, injury, neuroinflammation and other pathological…”
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Characterization of febrile seizures and febrile seizure susceptibility in mouse inbred strains by Van Gassen, K. L. I., Hessel, E. V. S., Ramakers, G. M. J., Notenboom, R. G. E., Wolterink‐Donselaar, I. G., Brakkee, J. H., Godschalk, T. C., Qiao, X., Spruijt, B. M., Van Nieuwenhuizen, O., De Graan, P. N. E.

“…Febrile seizures (FS) are the most prevalent seizures in children. Although FS are largely benign, complex FS increase the risk to develop temporal lobe…”
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High‐resolution genetic mapping of mammalian motor activity levels in mice by Kas, M. J. H., De Mooij‐van Malsen, J. G., De Krom, M., Van Gassen, K. L. I., Van Lith, H. A., Olivier, B., Oppelaar, H., Hendriks, J., De Wit, M., Groot Koerkamp, M. J. A., Holstege, F. C. P., Van Oost, B. A., De Graan, P. N. E.

“…The generation of motor activity levels is under tight neural control to execute essential behaviors, such as movement toward food or for social interaction…”
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Inhibition of noradrenaline release by antibodies to B-50 (GAP-43) by Dekker, L. V, Graan, P. N. E. De, Oestreicher, A. B, Versteeg, D. H. G, Gispen, W. H

“…Protein kinase C (PKC) is believed to have a crucial role in synaptic transmitter release and long-term potentiation. An important substrate of PKC in the…”
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Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility by Hessel, E. V. S., Van Gassen, K. L. I., Wolterink‐Donselaar, I. G., Stienen, P. J., Fernandes, C., Brakkee, J. H., Kas, M. J. H., De Graan, P. N. E.

“…Febrile seizures (FS) are the most common seizure type in children and recurrent FS are a risk factor for developing temporal lobe epilepsy. Although the…”
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Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy by Proper, E. A., Oestreicher, A. B., Jansen, G. H., Veelen, C. W. M. v., van Rijen, P. C., Gispen, W. H., de Graan, P. N. E.

“…Hippocampal sclerosis (HS) is a common derangement in many patients with temporal lobe epilepsy. As a result of neuronal cell loss in the hilar region of the…”
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Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6 by Nelson, T.E, Olde Engberink, A, Hernandez, R, Puro, A, Huitron-Resendiz, S, Hao, C, De Graan, P.N.E, Gruol, D.L

“…Highlight ► Transgenic mice with chronically elevated levels of IL-6 show enhanced excitatory synaptic transmission in the hippocampus…”
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Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase by MORITZ, A, DE GRAAN, P. N. E, GISPEN, W. H, WIRTZ, K. W. A

“…The lipid dependence of phosphatidylinositol-4-phosphate (PIP) kinase purified from bovine brain membranes was investigated. In the assay used, PIP-Triton…”
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Chronic exposure to the chemokine CCL3 enhances neuronal network activity in rat hippocampal cultures by Kuijpers, M, van Gassen, K.L.I, de Graan, P.N.E, Gruol, D

“…Abstract We examined the effect of chronic CCL3 treatment on the properties of cultured rat hippocampal neurons to gain an understanding of the neuronal…”
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Ontogeny of hippocampal corticosteroid receptors: Effects of antenatal glucocorticoids in human and mouse by Noorlander, C.W., De Graan, P.N.E., Middeldorp, J., Van Beers, J.J.B.C., Visser, G.H.A.

“…Women at risk for preterm delivery are treated with synthetic glucocorticoids (GCs) to enhance fetal lung maturation. GCs can bind to two intracellular…”
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Prenatal corticosteroid exposure affects hippocampal plasticity and reduces lifespan by Noorlander, C.W., Visser, G.H.A., Ramakers, G.M.J., Nikkels, P.G.J., de Graan, P.N.E.

“…Synthetic corticosteroids, such as dexamethasone, are frequently administered to pregnant women at risk for preterm delivery. Endogenous corticosteroids are…”
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B-50 phosphorylation and polyphosphoinositide metabolism in nerve growth cone membranes by Van Hooff, CO, De Graan, PN, Oestreicher, AB, Gispen, WH

“…The neuron-specific phosphoprotein B-50 (Mr 48 kDa, isoelectric point, IEP, 4.5), which is identical to GAP43, is a member of a family of growth-associated…”
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Haploinsufficiency of glutamine synthetase increases susceptibility to experimental febrile seizures by Van Gassen, K. L. I., Van Der Hel, W. S., Hakvoort, T. B. M., Lamers, W. H., De Graan, P. N. E.

“…Glutamine synthetase (GS) is a pivotal glial enzyme in the glutamate–glutamine cycle. GS is important in maintaining low extracellular glutamate concentrations…”
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Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsy by VAN DER HEL, W. S, NOTENBOOM, R. G. E, BOS, I. W. M, VAN RIJEN, P. C, VAN VEELEN, C. W. M, DE GRAAN, P. N. E

“…Increased levels of glutamate have been reported in the epileptogenic hippocampus of patients with temporal lobe epilepsy (TLE). This sustained increase, which…”
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Phosphorylation of B-50 (GAP43) is correlated with neurotransmitter release in rat hippocampal slices by Dekker, L V, De Graan, P N, Versteeg, D H, Oestreicher, A B, Gispen, W H

“…Recent studies have demonstrated that phorbol diesters enhance the release of various neurotransmitters. It is generally accepted that activation of protein…”
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Nerve Growth Factor-Induced Changes in the Intracellular Localization of the Protein Kinase C Substrate B-50 in Pheochromocytoma PC12 Cells by Carien O. M. Van Hooff, Joost C. M. Holthuis, Oestreicher, A. Beate, Boonstra, Johannes, Pierre N. E. De Graan, Gispen, Willem Hendrik

“…High levels of the neuron-specific protein kinase C substrate, B-50 (= GAP43), are present in neurites and growth cones during neuronal development and…”
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Depolarization-induced phosphorylation of the protein kinase C substrate B-50 (GAP-43) in rat cortical synaptosomes by Dekker, L V, De Graan, P N, De Wit, M, Hens, J J, Gispen, W H

“…We studied the molecular events underlying K(+)-induced phosphorylation of the neuron-specific protein kinase C substrate B-50. Rat cortical synaptosomes were…”
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Increased glutamine synthetase but normal EAAT2 expression in platelets of ALS patients by Bos, I.W.M., Hoogland, G., Meine Jansen, C.F., Willigen, G. van, Spierenburg, H.A., van den Berg, L.H., de Graan, P.N.E.

“…Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and glutamate excitotoxicity has been implicated in its pathogenesis. Platelets contain a…”
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