Search Results - "De Graaf, A A"

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells by Kind, Jop, Pagie, Ludo, de Vries, Sandra S., Nahidiazar, Leila, Dey, Siddharth S., Bienko, Magda, Zhan, Ye, Lajoie, Bryan, de Graaf, Carolyn A., Amendola, Mario, Fudenberg, Geoffrey, Imakaev, Maxim, Mirny, Leonid A., Jalink, Kees, Dekker, Job, van Oudenaarden, Alexander, van Steensel, Bas

“…Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-associated domains (LADs). We report a method to map NL…”
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Alpha-band rhythms in visual task performance: phase-locking by rhythmic sensory stimulation by de Graaf, Tom A, Gross, Joachim, Paterson, Gavin, Rusch, Tessa, Sack, Alexander T, Thut, Gregor

“…Oscillations are an important aspect of neuronal activity. Interestingly, oscillatory patterns are also observed in behaviour, such as in visual performance…”
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Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies by Samuels, Noor, van de Graaf, Rob A, de Jonge, Rogier C J, Reiss, Irwin K M, Vermeulen, Marijn J

“…Necrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into…”
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Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans by Choi, Jarny, Baldwin, Tracey M, Wong, Mae, Bolden, Jessica E, Fairfax, Kirsten A, Lucas, Erin C, Cole, Rebecca, Biben, Christine, Morgan, Clare, Ramsay, Kerry A, Ng, Ashley P, Kauppi, Maria, Corcoran, Lynn M, Shi, Wei, Wilson, Nick, Wilson, Michael J, Alexander, Warren S, Hilton, Douglas J, de Graaf, Carolyn A

“…Abstract During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many lineages required…”
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Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial by van der Steen, Wouter, van de Graaf, Rob A, Chalos, Vicky, Lingsma, Hester F, van Doormaal, Pieter Jan, Coutinho, Jonathan M, Emmer, Bart J, de Ridder, Inger, van Zwam, Wim, van der Worp, H Bart, van der Schaaf, Irene, Gons, Rob A R, Yo, Lonneke S F, Boiten, Jelis, van den Wijngaard, Ido, Hofmeijer, Jeannette, Martens, Jasper, Schonewille, Wouter, Vos, Jan Albert, Tuladhar, Anil Man, de Laat, Karlijn F, van Hasselt, Boudewijn, Remmers, Michel, Vos, Douwe, Rozeman, Anouk, Elgersma, Otto, Uyttenboogaart, Maarten, Bokkers, Reinoud P H, van Tuijl, Julia, Boukrab, Issam, van den Berg, René, Beenen, Ludo F M, Roosendaal, Stefan D, Postma, Alida Annechien, Krietemeijer, Menno, Lycklama, Geert, Meijer, Frederick J A, Hammer, Sebastiaan, van der Hoorn, Anouk, Yoo, Albert J, Gerrits, Dick, Truijman, Martine T B, Zinkstok, Sanne, Koudstaal, Peter J, Manschot, Sanne, Kerkhoff, Henk, Nieboer, Daan, Berkhemer, Olvert, Wolff, Lennard, van der Sluijs, P Matthijs, van Voorst, Henk, Tolhuisen, Manon, Roos, Yvo B W E M, Majoie, Charles B L M, Staals, Julie, van Oostenbrugge, Robert J, Jenniskens, Sjoerd F M, van Dijk, Lukas C, den Hertog, Heleen M, van Es, Adriaan C G M, van der Lugt, Aad, Dippel, Diederik W J, Roozenbeek, Bob

“…Aspirin and unfractionated heparin are often used during endovascular stroke treatment to improve reperfusion and outcomes. However, the effects and risks of…”
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Phase of beta-frequency tACS over primary motor cortex modulates corticospinal excitability by Schilberg, Lukas, Engelen, Tahnée, ten Oever, Sanne, Schuhmann, Teresa, de Gelder, Beatrice, de Graaf, Tom A., Sack, Alexander T.

“…The assessment of corticospinal excitability by means of transcranial magnetic stimulation-induced motor evoked potentials is an established diagnostic tool in…”
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Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread by Büll, Christian, Boltje, Thomas Jan, van Dinther, Eric A. W, Peters, Timo, de Graaf, Annemarie M. A, Leusen, Jeanette H. W, Kreutz, Martin, Figdor, Carl G, den Brok, Martijn H, Adema, Gosse J

“…Sialic acid sugars are overexpressed by cancer cells and contribute to the metastatic cascade at multiple levels. Therapeutic interference of sialic acids,…”
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Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N‑Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group by Muenzner, Julienne K, Rehm, Tobias, Biersack, Bernhard, Casini, Angela, de Graaf, Inge A. M, Worawutputtapong, Pawida, Noor, Awal, Kempe, Rhett, Brabec, Viktor, Kasparkova, Jana, Schobert, Rainer

“…Five platinum­(II) complexes bearing a (1,3-dibenzyl)­imidazol-2-ylidene ligand but different leaving groups trans to it were examined for cytotoxicity, DNA…”
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In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis by Biben, C., Weber, T. S., Potts, K. S., Choi, J., Miles, D. C., Carmagnac, A., Sargeant, T., de Graaf, C. A., Fennell, K. A., Farley, A., Stonehouse, O. J., Dawson, M. A., Hilton, D. J., Naik, S. H., Taoudi, S.

“…During embryogenesis, haematopoietic and endothelial lineages emerge closely in time and space. It is thought that the first blood and endothelium derive from…”
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Deuterium metabolic imaging – Back to the future by De Feyter, Henk M., de Graaf, Robin A.

“…[Display omitted] •The promise of deuterium as a metabolic tracer was recognized soon after the discovery of chemical isotopes.•Deuterium NMR has only seen…”
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Anticancer Gold N‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study by Estrada‐Ortiz, Natalia, Guarra, Federica, de Graaf, Inge A. M., Marchetti, Lorella, de Jager, Marina H., Groothuis, Geny M. M., Gabbiani, Chiara, Casini, Angela

“…A series of organometallic AuI N‐heterocyclic carbene (NHC) complexes was synthesized and characterized for anticancer activity in four human cancer cell…”
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Concurrent human TMS-EEG-fMRI enables monitoring of oscillatory brain state-dependent gating of cortico-subcortical network activity by Peters, Judith C., Reithler, Joel, Graaf, Tom A. de, Schuhmann, Teresa, Goebel, Rainer, Sack, Alexander T.

“…Despite growing interest, the causal mechanisms underlying human neural network dynamics remain elusive. Transcranial Magnetic Stimulation (TMS) allows to…”
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Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells by Hof, Willemien F J, Visser, Miranda, de Jong, Joyce J, Rajasekar, Marian N, Schuringa, Jan Jacob, de Graaf, Inge A M, Touw, Daan J, Dekkers, Bart G J

“…poisonings account for the majority of fatal mushroom poisonings. Recently, we identified hematotoxicity as a relevant aspect of poisonings. In this study, we…”
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Beyond diversity: functional microbiomics of the human colon by Egert, Markus, de Graaf, Albert A., Smidt, Hauke, de Vos, Willem M., Venema, Koen

“…Molecular tools have revealed wide microbial diversity in the human alimentary tract. Most intestinal microorganisms have not been cultured and the in situ…”
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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity by Sulkowski, Parker L, Corso, Christopher D, Robinson, Nathaniel D, Scanlon, Susan E, Purshouse, Karin R, Bai, Hanwen, Liu, Yanfeng, Sundaram, Ranjini K, Hegan, Denise C, Fons, Nathan R, Breuer, Gregory A, Song, Yuanbin, Mishra-Gorur, Ketu, De Feyter, Henk M, de Graaf, Robin A, Surovtseva, Yulia V, Kachman, Maureen, Halene, Stephanie, Günel, Murat, Glazer, Peter M, Bindra, Ranjit S

“…2-Hydroxyglutarate (2HG) exists as two enantiomers, (R)-2HG and (S)-2HG, and both are implicated in tumor progression via their inhibitory effects on…”
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Thrombopoietin and hematopoietic stem cells by de Graaf, Carolyn A., Metcalf, Donald

“…Thrombopoietin (TPO) is the cytokine that is chiefly responsible for megakaryocyte production but increasingly attention has turned to its role in maintaining…”
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The Contribution of GABA to Glutamate/Glutamine Cycling and Energy Metabolism in the Rat Cortex in vivo by Patel, Anant B., de Graaf, Robin A., Mason, Graeme F., Rothman, Douglas L., Shulman, Robert G., Behar, Kevin L.

“…Previous studies have shown that the glutamate/glutamine (Glu/Gln) neurotransmitter cycle and neuronal glucose oxidation are proportional (1:1), with…”
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Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation by van Schalkwijk, Daniël B, Pasman, Wilrike J, Hendriks, Henk F J, Verheij, Elwin R, Rubingh, Carina M, van Bochove, Kees, Vaes, Wouter H J, Adiels, Martin, Freidig, Andreas P, de Graaf, Albert A

“…Dietary medium chain fatty acids (MCFA) and linoleic acid follow different metabolic routes, and linoleic acid activates PPAR receptors. Both these mechanisms…”
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Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution by Ruhm, Loreen, Avdievich, Nikolai, Ziegs, Theresia, Nagel, Armin M., De Feyter, Henk M., de Graaf, Robin A., Henning, Anke

“…To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast…”
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Genetic diversity within leukemia-associated immunophenotype-defined subclones in AML by Tiso, F., Koorenhof-Scheele, T. N., Huys, E., Martens, J. H. A., de Graaf, A. O., van der Reijden, B. A., Langemeijer, S. M. C., Preijers, F. W. M. B., Kroeze, L. I., Jansen, J. H.

“…Acute myeloid leukemia (AML) is a highly heterogeneous disease showing dynamic clonal evolution patterns over time. Various subclones may be present…”
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