Search Results - "De Franceschi, Giorgia"

Global analysis of protein structural changes in complex proteomes by Feng, Yuehan, De Franceschi, Giorgia, Kahraman, Abdullah, Soste, Martin, Melnik, Andre, Boersema, Paul J, de Laureto, Patrizia Polverino, Nikolaev, Yaroslav, Oliveira, Ana Paula, Picotti, Paola

“…Coupling limited proteolysis and a proteomics workflow enables measurement of both subtle and wholesale protein conformational changes in a eukaryotic…”
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α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity by Fecchio, Chiara, De Franceschi, Giorgia, Relini, Annalisa, Greggio, Elisa, Dalla Serra, Mauro, Bubacco, Luigi, Polverino de Laureto, Patrizia

“…A key feature of Parkinson disease is the aggregation of α-synuclein and its intracellular deposition in fibrillar form. Increasing evidence suggests that the…”
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Covalent α-synuclein dimers: chemico-physical and aggregation properties by Pivato, Micaela, De Franceschi, Giorgia, Tosatto, Laura, Frare, Erica, Kumar, Dhruv, Aioanei, Daniel, Brucale, Marco, Tessari, Isabella, Bisaglia, Marco, Samori, Bruno, de Laureto, Patrizia Polverino, Bubacco, Luigi

“…The aggregation of α-synuclein into amyloid fibrils constitutes a key step in the onset of Parkinson's disease. Amyloid fibrils of α-synuclein are the major…”
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Changes in protein expression in two cholangiocarcinoma cell lines undergoing formation of multicellular tumor spheroids in vitro by Mischiati, Carlo, Ura, Blendi, Roncoroni, Leda, Elli, Luca, Cervellati, Carlo, Squerzanti, Monica, Conte, Dario, Doneda, Luisa, Polverino de Laureto, Patrizia, de Franceschi, Giorgia, Calza, Roberta, Barrero, Carlos A, Merali, Salim, Ferrari, Carlo, Bergamini, Carlo M, Agostinelli, Enzo

“…Epithelial-to-Mesenchymal Transition (EMT) is relevant in malignant growth and frequently correlates with worsening disease progression due to its implications…”
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The functional dissection of the plasma corona of SiO₂-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages by Fedeli, Chiara, Segat, Daniela, Tavano, Regina, Bubacco, Luigi, De Franceschi, Giorgia, de Laureto, Patrizia Polverino, Lubian, Elisa, Selvestrel, Francesco, Mancin, Fabrizio, Papini, Emanuele

“…A coat of strongly-bound host proteins, or hard corona, may influence the biological and pharmacological features of nanotheranostics by altering their…”
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α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection by De Franceschi, Giorgia, Fecchio, Chiara, Sharon, Ronit, Schapira, Anthony H.V., Proukakis, Christos, Bellotti, Vittorio, de Laureto, Patrizia Polverino

“…α-Synuclein (aS) is a protein abundant in presynaptic nerve terminals in Parkinson disease (PD) and is a major component of intracellular Lewy bodies, the…”
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Structural and Morphological Characterization of Aggregated Species of α-Synuclein Induced by Docosahexaenoic Acid by De Franceschi, Giorgia, Frare, Erica, Pivato, Micaela, Relini, Annalisa, Penco, Amanda, Greggio, Elisa, Bubacco, Luigi, Fontana, Angelo, de Laureto, Patrizia Polverino

“…The interaction of brain lipids with α-synuclein may play an important role in the pathogenesis of Parkinson disease (PD). Docosahexaenoic acid (DHA) is an…”
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The oleic acid complexes of proteolytic fragments of α‐lactalbumin display apoptotic activity by Tolin, Serena, De Franceschi, Giorgia, Spolaore, Barbara, Frare, Erica, Canton, Marcella, Polverino de Laureto, Patrizia, Fontana, Angelo

“…The complexes formed by partially folded human and bovine α‐lactalbumin with oleic acid (OA) have been reported to display selective apoptotic activity against…”
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Variations of the corona HDL:albumin ratio determine distinct effects of amorphous SiO2 nanoparticles on monocytes and macrophages in serum by Fedeli, Chiara, Segat, Daniela, Tavano, Regina, De Franceschi, Giorgia, de Laureto, Patrizia Polverino, Lubian, Elisa, Selvestrel, Francesco, Mancin, Fabrizio, Papini, Emanuele

“…We investigated monocyte and macrophage death and cytokine production induced by amorphous silica nanoparticles (SiO2-NPs) to clarify the role of defined serum…”
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Molecular Insights into the Interaction between α-Synuclein and Docosahexaenoic Acid by De Franceschi, Giorgia, Frare, Erica, Bubacco, Luigi, Mammi, Stefano, Fontana, Angelo, de Laureto, Patrizia Polverino

“…α-Synuclein (α-syn) is a 140-residue protein of unknown function, involved in several neurodegenerative disorders, such as Parkinson's disease. Recently, the…”
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Amyloid Fibril Formation and Disaggregation of Fragment 1-29 of Apomyoglobin: Insights into the Effect of pH on Protein Fibrillogenesis by Picotti, Paola, De Franceschi, Giorgia, Frare, Erica, Spolaore, Barbara, Zambonin, Marcello, Chiti, Fabrizio, de Laureto, Patrizia Polverino, Fontana, Angelo

“…The N-terminal fragment 1–29 of horse heart apomyoglobin (apoMb 1–29) is highly prone to form amyloid-like fibrils at low pH. Fibrillogenesis at pH 2.0 occurs…”
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Covalent [alpha]-Synuclein Dimers: Chemico-Physical and Aggregation Properties by Pivato, Micaela, De Franceschi, Giorgia, Tosatto, Laura, Frare, Erica, Kumar, Dhruv, Aioanei, Daniel, Brucale, Marco, Tessari, Isabella, Bisaglia, Marco, Samori, Bruno, de Laureto, Patrizia Polverino, Bubacco, Luigi

“…The aggregation of [alpha]-synuclein into amyloid fibrils constitutes a key step in the onset of Parkinson's disease. Amyloid fibrils of [alpha]-synuclein are…”
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The role of tryptophan in protein fibrillogenesis: relevance of Trp7 and Trp14 to the amyloidogenic properties of myoglobin by Cecchini, Paola, De Franceschi, Giorgia, Frare, Erica, Fontana, Angelo, Polverino de Laureto, Patrizia

“…In order to understand the role of tryptophan in the mechanisms of fibrils formation, the ability of a series of analogs of the residue 7–18 span of myoglobin…”
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The oleic acid complexes of proteolytic fragments of [alpha]-lactalbumin display apoptotic activity by Tolin, Serena, De Franceschi, Giorgia, Spolaore, Barbara, Frare, Erica, Canton, Marcella, Polverino de Laureto, Patrizia, Fontana, Angelo

“…The complexes formed by partially folded human and bovine [alpha]-lactalbumin with oleic acid (OA) have been reported to display selective apoptotic activity…”
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alpha -Synuclein Oligomers Induced by Docosahexaenoic Acid Affect Membrane Integrity: e82732 by Fecchio, Chiara, Franceschi, Giorgia De, Relini, Annalisa, Greggio, Elisa, Serra, Mauro Dalla, Bubacco, Luigi, Laureto, Patrizia Polverinode

“…A key feature of Parkinson disease is the aggregation of alpha -synuclein and its intracellular deposition in fibrillar form. Increasing evidence suggests that…”
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