Liposome-delivered 131I-labelled Zn(II)-phthalocyanine as a radiodiagnostic agent for tumours

131I-Zn(II)-phthalocyanine (ZnPc) incorporated into unilamellar liposomes has been systemically injected to mice bearing a transplanted MS-2 fibrosarcoma. Biodistribution studies show that the pharmacokinetic behaviour of 131I-ZnPc is very similar to that defined for the parent molecule ZnPc includi...

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Bibliographic Details
Published in:	Cancer letters Vol. 109; no. 1; pp. 57 - 61
Main Authors:	Polo, Laura, Segalla, Anna, Jori, Giulio, Bocchiotti, Giovanni, Verna, Giovanni, Franceschini, Rodolfo, Mosca, Renzo, De Filippi, Pier Giorgio
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 03-12-1996 Elsevier
Subjects:	Animals Biological and medical sciences Contrast media. Radiopharmaceuticals Fibrosarcoma - diagnostic imaging Fibrosarcoma - metabolism Gamma-camera Indoles - pharmacokinetics Iodine Radioisotopes - pharmacokinetics Liposomes Medical sciences Mice Mice, Inbred BALB C Muscles - metabolism Organometallic Compounds - pharmacokinetics Pharmacology. Drug treatments Phthalocyanine Radiodiagnostic agents Radionuclide Imaging Time Factors Tissue Distribution Tumor Cells, Cultured Tumours Phthalocyanine Gamma-camera Liposomes Tumours Radiodiagnostic agents Intravenous administration Sarcoma Rodentia Liposome Fibrosarcoma Malignant tumor Radioisotope Diagnostic agent Vertebrata Mammalia Mouse Metallophthalocyanine Animal Dosage form Pharmacokinetics Zinc Complexes Photosensitizer Labelled compound
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Summary:	131I-Zn(II)-phthalocyanine (ZnPc) incorporated into unilamellar liposomes has been systemically injected to mice bearing a transplanted MS-2 fibrosarcoma. Biodistribution studies show that the pharmacokinetic behaviour of 131I-ZnPc is very similar to that defined for the parent molecule ZnPc including a serum half-life of ca. 12 h, a high recovery from liver and spleen and minimal accumulation in kidney and brain The most important pharmacokinetic parameter is represented by the high tumour/ muscle ratio of 131I-ZnPc concentration (ca. 9 at 24 h post-injection). These results suggest the possible use of the radiolabelled derivative for a real-time non-invasive monitoring of the ZnPc concentration in the tumour and peritumoural tissue during photodynamic therapy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3835 1872-7980
DOI:	10.1016/S0304-3835(96)04409-6