Search Results - "De Doncker, Mireille"

Nail analysis for the detection of drugs of abuse and pharmaceuticals: a review by Cappelle, Delphine, Yegles, Michel, Neels, Hugo, van Nuijs, Alexander L. N., De Doncker, Mireille, Maudens, Kristof, Covaci, Adrian, Crunelle, Cleo L.

“…Nails can stably accumulate substances for long periods of time, thus providing retrospective information regarding drugs of abuse and pharmaceutical use…”
Get full text

Keratinous matrices for the assessment of drugs of abuse consumption: A correlation study between hair and nails by Cappelle, Delphine, De Keukeleire, Steven, Neels, Hugo, Been, Frederic, De Doncker, Mireille, Dom, Geert, Crunelle, Cleo L., Covaci, Adrian, Nuijs, Alexander L.N.

“…Keratinous matrices – hair and nails – accumulate substances over time and allow retrospective investigation of past consumption. Analysis of these matrices…”
Get full text

Ethyl glucuronide concentrations in hair: a controlled alcohol-dosing study in healthy volunteers by L. Crunelle, Cleo, Cappelle, Delphine, Yegles, Michel, De Doncker, Mireille, Michielsen, Peter, Dom, Geert, van Nuijs, Alexander L. N, Maudens, Kristof E, Covaci, Adrian, Neels, Hugo

“…Ethyl glucuronide (EtG) is a minor phase II metabolite of alcohol that accumulates in hair. It has been established as a sensitive marker to assess the…”
Get full text

Ethyl glucuronide in hair of non-excessive alcohol consumers: correlations and gender influence by Crunelle, Cleo L., Cappelle, Delphine, Flamand, Eva, Cox, Jeroen, Covaci, Adrian, De Doncker, Mireille, van Nuijs, Alexander L. N., Michielsen, Peter, Yegles, Michel, Neels, Hugo

“…Hair ethyl glucuronide (hEtG) is a marker used for previous alcohol consumption. Correlations have been reported between the amount of alcohol consumed and…”
Get full text

Cibenzoline intoxication: Effect of combined hemoperfusion-hemodialysis on plasma clearance by Meeus, Roel, Verpooten, Gert A., De Paep, Rudi, Paelinck, Bernard P., Neels, Hugo, Cooreman, Sarah, De Doncker, Mireille, Jorens, Philippe G.

“…Introduction. Cibenzoline is an antiarrhythmic drug used to treat patients with supraventricular or ventricular arrhythmias. Cibenzoline overdose is associated…”
Get full text

High throughput identification and quantification of 16 antipsychotics and 8 major metabolites in serum using ultra-high performance liquid chromatography–tandem mass spectrometry by Patteet, Lisbeth, Maudens, Kristof E., Sabbe, Bernard, Morrens, Manuel, De Doncker, Mireille, Neels, Hugo

“…Therapeutic drug monitoring of antipsychotics is important for optimizing therapy, explaining adverse effects, non-response or poor compliance. We developed a…”
Get full text

A straightforward, validated liquid chromatography coupled to tandem mass spectrometry method for the simultaneous detection of nine drugs of abuse and their metabolites in hair and nails by Cappelle, Delphine, De Doncker, Mireille, Gys, Celine, Krysiak, Kamelia, De Keukeleire, Steven, Maho, Walid, Crunelle, Cleo L., Dom, Geert, Covaci, Adrian, van Nuijs, Alexander L.N., Neels, Hugo

“…Hair and nails allow for a stable accumulation of compounds over time and retrospective investigation of past exposure and/or consumption. Owing to their long…”
Get full text

Ethyl Glucuronide in Hair Is an Accurate Biomarker of Chronic Excessive Alcohol Use in Patients With Alcoholic Cirrhosis by Verbeek, Jef, Crunelle, Cleo L., Leurquin-Sterk, Gil, Michielsen, Peter P., De Doncker, Mireille, Monbaliu, Diethard, Pirenne, Jacques, Roskams, Tania, van der Merwe, Schalk, Cassiman, David, Neels, Hugo, Nevens, Frederik

Get full text

Continuous administration of the mTORC1 inhibitor everolimus induces tolerance and decreases autophagy in mice by Kurdi, Ammar, De Doncker, Mireille, Leloup, Arthur, Neels, Hugo, Timmermans, Jean‐Pierre, Lemmens, Katrien, Apers, Sandra, De Meyer, Guido R Y, Martinet, Wim

“…Background and Purpose Everolimus is an allosteric inhibitor of the mechanistic target of rapamycin complex 1 (mTORC1) widely known for its potent autophagy…”
Get full text

Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis by Kurdi, Ammar, Roth, Lynn, Van der Veken, Bieke, Van Dam, Debby, De Deyn, Peter P., De Doncker, Mireille, Neels, Hugo, De Meyer, Guido R.Y., Martinet, Wim

“…Inhibition of the mechanistic target of rapamycin (mTOR) is a promising approach to halt atherogenesis in different animal models. This study evaluated whether…”
Get full text

Hair ethyl glucuronide concentrations in teetotalers: Should we re-evaluate the lower cut-off? by Crunelle, Cleo L, Yegles, Michel, De Doncker, Mireille, Cappelle, Delphine, Covaci, Adrian, van Nuijs, Alexander L.N, Neels, Hugo

“…Highlights • Hair EtG concentrations remain detectable following abstinence. • Sensitive analytical methods are preferred when assessing alcohol abstinence. •…”
Get full text

Influence of Body Mass Index on Hair Ethyl Glucuronide Concentrations by Crunelle, Cleo L, Neels, Hugo, Maudens, Kristof, De Doncker, Mireille, Cappelle, Delphine, Matthys, Frieda, Dom, Geert, Fransen, Erik, Michielsen, Peter, De Keukeleire, Steven, Covaci, Adrian, Yegles, Michel

“…Analysis of ethyl glucuronide (EtG) concentrations in hair is increasingly used to estimate the consumption of alcohol of the prior months. Linear correlations…”
Get full text

Retrospective evaluation of therapeutic drug monitoring of clozapine and norclozapine in Belgium using a multidrug UHPLC–MS/MS method by Patteet, Lisbeth, Maudens, Kristof E., Vermeulen, Zarha, Dockx, Greetje, De Doncker, Mireille, Morrens, Manuel, Sabbe, Bernard, Neels, Hugo

“…Clozapine is an atypical antipsychotic with a narrow therapeutic range and serious toxic side effects. According to AGNP–TDM consensus guidelines, therapeutic…”
Get full text

Hair ethyl glucuronide and serum carbohydrate deficient transferrin for the assessment of relapse in alcohol-dependent patients by Crunelle, Cleo L., Verbeek, Jef, Dom, Geert, Covaci, Adrian, Yegles, Michel, Michielsen, Peter, De Doncker, Mireille, Nevens, Frederik, Cappelle, Delphine, van Nuijs, Alexander L.N., Neels, Hugo

“…Ethyl glucuronide in hair (hEtG) and serum carbohydrate deficient transferrin (%CDT) are valuable markers for alcohol abuse, but their diagnostic accuracy to…”
Get full text

Influence of repeated permanent coloring and bleaching on ethyl glucuronide concentrations in hair from alcohol-dependent patients by Crunelle, Cleo L, Yegles, Michel, De Doncker, Mireille, Dom, Geert, Cappelle, Delphine, Maudens, Kristof E, van Nuijs, Alexander L.N, Covaci, Adrian, Neels, Hugo

“…Highlights • Hair EtG can be used to assess chronic alcohol use of the prior 18 months. • Permanent coloring and bleaching reduces EtG concentrations in hair…”
Get full text

Hair ethyl glucuronide levels as a marker for alcohol use and abuse: A review of the current state of the art by Crunelle, Cleo L, Yegles, Michel, Nuijs, Alexander L.N. van, Covaci, Adrian, De Doncker, Mireille, Maudens, Kristof E, Sabbe, Bernard, Dom, Geert, Lambert, Willy E, Michielsen, Peter, Neels, Hugo

“…Abstract Background Ethyl glucuronide (EtG) is a minor alcohol metabolite that has been proposed as a stable marker in hair to detect and quantify alcohol…”
Get full text

Ethyl glucuronide determination in meconium and hair by hydrophilic interaction liquid chromatography–tandem mass spectrometry by Tarcomnicu, Isabela, van Nuijs, Alexander L.N, Aerts, Katrien, De Doncker, Mireille, Covaci, Adrian, Neels, Hugo

“…Abstract Ethyl glucuronide (EtG) detection in non-conventional matrices, such as hair and meconium, can provide useful information on alcohol abuse over a long…”
Get full text

Ethylene glycol poisoning: Quintessential clinical toxicology; analytical conundrum by Van hee, Paul, Neels, Hugo, De Doncker, Mireille, Maudens, Kristof E., Lambert, Willy, Patteet, Lisbeth

Get full text

Analysis of gamma-hydroxybutyric acid, DL-lactic acid, glycolic acid, ethylene glycol and other glycols in body fluids by a direct injection gas chromatography-mass spectrometry assay for wide use by Van Hee, Paul, Neels, Hugo, De Doncker, Mireille, Vrydags, Nicolas, Schatteman, Katinka, Uyttenbroeck, Wim, Hamers, Nicole, Himpe, Dirk, Lambert, Willy

“…Analysis of blood of severely intoxicated patients always requires prompt investigation. Diagnosis of intoxication with ethylene glycol, gamma-hydroxybutyric…”
Get more information

Analysis Of ??-hydroxy Butyric Acid, DL-lactic Acid, Glycolic Acid, Ethylene Glycol And Other Glycols In Body Fluids By A Direct Injection Gas Chromatography Mass Spectrometry Assay For Wide Use: 65 by Van hee, Paul, Neels, Hugo, Doncker, Mireille De, Vrydags, Nicolas, Schatteman, Katinka, Uyttenbroeck, Wim, Hamers, Nicole, Himpe, Dirk, Lambert, Willy

Get full text