Search Results - "De Deken, Xavier"

Genomewide Location Analysis of Candida albicans Upc2p, a Regulator of Sterol Metabolism and Azole Drug Resistance by Znaidi, Sadri, Weber, Sandra, Al-Abdin, Osman Zin, Bomme, Perrine, Saidane, Saloua, Drouin, Simon, Lemieux, Sébastien, De Deken, Xavier, Robert, François, Raymond, Martine

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NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation by Ameziane-El-Hassani, Rabii, Talbot, Monique, de Souza Dos Santos, Maria Carolina, Al Ghuzlan, Abir, Hartl, Dana, Bidart, Jean-Michel, De Deken, Xavier, Miot, Françoise, Diallo, Ibrahima, de Vathaire, Florent, Schlumberger, Martin, Dupuy, Corinne

“…Ionizing radiation (IR) causes not only acute tissue damage, but also late effects in several cell generations after the initial exposure. The thyroid gland is…”
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Mice Deficient in Dual Oxidase Maturation Factors Are Severely Hypothyroid by Grasberger, Helmut, De Deken, Xavier, Mayo, Olga Barca, Raad, Houssam, Weiss, Mia, Liao, Xiao-Hui, Refetoff, Samuel

“…Dual oxidases (DUOX1 and DUOX2) are evolutionary conserved reduced nicotinamide adenine dinucleotide phosphate oxidases responsible for regulated hydrogen…”
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Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ by Driessens, Natacha, Versteyhe, Soetkin, Ghaddhab, Chiraz, Burniat, Agnès, De Deken, Xavier, Van Sande, Jacqueline, Dumont, Jacques-Emile, Miot, Françoise, Corvilain, Bernard

“…DNA double-strand breaks (DSBs) are considered as one of the primary causes of cancer but their induction by hydrogen peroxide (H2O2) is still controversial…”
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Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR by Diebold, Becky A, Wilder, S Garrett, De Deken, Xavier, Meitzler, Jennifer L, Doroshow, James H, McCoy, James W, Zhu, Yerun, Lambeth, J David

“…The identification of NADPH oxidase (NOX) isoforms in tissues is essential for interpreting experiments and for next step decisions regarding cell lines,…”
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Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation by Dickinson, John D., Sweeter, Jenea M., Warren, Kristi J., Ahmad, Iman M., De Deken, Xavier, Zimmerman, Matthew C., Brody, Steven L.

“…The airway epithelium is a broad interface with the environment, mandating well-orchestrated responses to properly modulate inflammation. Classically,…”
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Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes by MACPHERSON, Sarah, AKACHE, Bassel, WEBER, Sandra, DE DEKEN, Xavier, RAYMOND, Martine, TURCOTTE, Bernard

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Urothelial cells produce hydrogen peroxide through the activation of Duox1 by Donkó, Ágnes, Ruisanchez, Éva, Orient, Anna, Enyedi, Balázs, Kapui, Réka, Péterfi, Zalán, de Deken, Xavier, Benyó, Zoltán, Geiszt, Miklós

“…Hydrogen peroxide (H 2O 2) has important messenger and effector functions in the plant and animal kingdom. Phagocytes produce H 2O 2 to kill pathogens, and…”
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Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family by De Deken, Xavier, Wang, Dantong, Many, Marie-Christine, Costagliola, Sabine, Libert, Frédérick, Vassart, Gilbert, Dumont, Jacques E., Miot, Françoise

“…Two cDNAs encoding NADPH oxidases and constituting the thyroid H2O2 generating system have been cloned. The strategy of cloning was based on the functional…”
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IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response by Fink, Karin, Martin, Lydie, Mukawera, Esperance, Chartier, Stéfany, Deken, Xavier De, Brochiero, Emmanuelle, Miot, Françoise, Grandvaux, Nathalie

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Characterization of ThOX Proteins as Components of the Thyroid H2O2-Generating System by De Deken, Xavier, Wang, Dantong, Dumont, Jacques E., Miot, Françoise

“…We have recently cloned two thyroid-specific cDNAs encoding new members of the NADPH oxidase family. ThOX1 and ThOX2 proteins are colocalized with…”
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Stroma cell-derived factor-1α signaling enhances calcium transients and beating frequency in rat neonatal cardiomyocytes by Hadad, Ielham, Veithen, Alex, Springael, Jean-Yves, Sotiropoulou, Panagiota A, Mendes Da Costa, Agnès, Miot, Françoise, Naeije, Robert, De Deken, Xavier, Entee, Kathleen Mc

“…Stroma cell-derived factor-1α (SDF-1α) is a cardioprotective chemokine, acting through its G-protein coupled receptor CXCR4. In experimental acute myocardial…”
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Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult by Milenkovic, Milutin, De Deken, Xavier, Jin, Ling, De Felice, Mario, Di Lauro, Roberto, Dumont, Jacques E, Corvilain, Bernard, Miot, Francoise

“…In the thyroid, H2O2 is produced at the apical pole of thyrocytes by one or two NADPH oxidases (NOX), Duox1/2 proteins. The onset of Duox expression was…”
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Constitutive Activation of the PDR16 Promoter in a Candida albicans Azole-Resistant Clinical Isolate Overexpressing CDR1 and CDR2 by DE DEKEN, Xavier, RAYMOND, Martine

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DUOX Defects and Their Roles in Congenital Hypothyroidism by De Deken, Xavier, Miot, Françoise

“…Extracellular hydrogen peroxide is required for thyroperoxidase-mediated thyroid hormone synthesis in the follicular lumen of the thyroid gland. Among the…”
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Activation of Dual Oxidases Duox1 and Duox2 by Rigutto, Sabrina, Hoste, Candice, Grasberger, Helmut, Milenkovic, Milutin, Communi, David, Dumont, Jacques E., Corvilain, Bernard, Miot, Françoise, De Deken, Xavier

“…Dual oxidases were initially identified as NADPH oxidases producing H2O2 necessary for thyroid hormone biosynthesis. The crucial role of Duox2 has been…”
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Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling by De Deken, Xavier, Corvilain, Bernard, Dumont, Jacques Emile, Miot, Françoise

“…Among the NADPH oxidases, the dual oxidases, DUOX1 and DUOX2, constitute a distinct subfamily initially called thyroid oxidases, based on their high level of…”
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Severe Autoimmune Thyroiditis in Transgenic NOD.H2 h4 Mice Expressing Interleukin-4 in the Thyroid by Merakchi, Karima, Djerbib, Sami, Dumont, Jacques-Emile, Miot, Françoise, De Deken, Xavier

“…Hashimoto's thyroiditis is a common autoimmune thyroid disorder characterized by thyroid lymphocytic infiltrates and autoreactive antibodies against…”
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Identification of a Novel Partner of Duox by Wang, Dantong, De Deken, Xavier, Milenkovic, Milutin, Song, Yue, Pirson, Isabelle, Dumont, Jacques E., Miot, Françoise

“…H2O2 is a crucial substrate of thyroproxidase (TPO) to iodinate thyroglobulin and synthesize thyroid hormones in thyroid. ThOX proteins (thyroid oxidase) also…”
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The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model by Poncelet, Louise, Dumont, Jacques-Emile, Miot, Françoise, De Deken, Xavier

“…Thyroid hormone synthesis requires H2O2, produced by two NADPH oxidases, Duox1 and Duox2. To be fully active at the apical pole of the thyrocytes, these…”
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