Search Results - "De Cristofaro, R"

On‐pump Cardiac Surgery Enhances Platelet Renewal and Impairs Aspirin Pharmacodynamics: Effects of Improved Dosing Regimens by Cavalca, V, Rocca, B, Veglia, F, Petrucci, G, Porro, B, Myasoedova, V, Cristofaro, R, Turnu, L, Bonomi, A, Songia, P, Cavallotti, L, Zanobini, M, Camera, M, Alamanni, F, Parolari, A, Patrono, C, Tremoli, E

“…On‐pump cardiac surgery may trigger inflammation and accelerate platelet cyclooxygenase‐1 renewal, thereby modifying low‐dose aspirin pharmacodynamics…”
Get full text

High mobility group box 1 is a novel substrate of dipeptidyl peptidase-IV by Marchetti, C., Di Carlo, A., Facchiano, F., Senatore, C., De Cristofaro, R., Luzi, A., Federici, M., Romani, M., Napolitano, M., Capogrossi, M. C., Germani, A.

“…Aims/hypothesis High mobility group box 1 (HMGB1) is a cytokine with a key role in tissue regeneration and angiogenesis. Previous studies have shown that…”
Get full text

Biochemical properties of indoleamine 2,3-dioxygenase: from structure to optimized design of inhibitors by Lancellotti, S, Novarese, L, De Cristofaro, R

“…The enzyme indoleamine 2,3-dioxygenase (IDO, EC 1.13.11.42) belongs to the family of heme-containing oxidoreductases and catalyzes the first and rate-limiting…”
Get more information

From angiotensin-converting enzyme 2 disruption to thromboinflammatory microvascular disease: A paradigm drawn from COVID-19 by Vinci, R., Pedicino, D., Andreotti, F., Russo, G., D'Aiello, A., De Cristofaro, R., Crea, F., Liuzzo, G.

“…We concisely review clinical, autopsy, experimental and molecular data of 2019 coronavirus disease (COVID-19). Angiotensin-converting enzyme 2 disruption and…”
Get full text

Qualitative and quantitative modifications of von Willebrand factor in patients with essential thrombocythemia and controlled platelet count by Lancellotti, S., Dragani, A., Ranalli, P., Petrucci, G., Basso, M., Tartaglione, R., Rocca, B., De Cristofaro, R.

“…Summary Background Essential thrombocythemia (ET) is characterized by increased platelets and prevalent thrombosis. An acquired von Willebrand factor (VWF)…”
Get full text

Effects of time to chemoradiation on high-grade gliomas from the Buenos Aires Metropolitan Area by Prost, Diego M, Merenzon, Martín A, Gómez-Escalante, José I, Primavera, Andrés, Vargas Benítez, Mara, Gil, Andrés S, Marenco, Pablo M, Califano, María M, Moughty Cueto, Carolina, Zaloff Dakoff, Juan M, Colonna, Mario, Mazzón, Alejandro, Zaninovich, Roberto S, De Cristófaro, Oscar R

“…High-Grade Gliomas (HGG) are the most frequent brain tumor in adults. The gold standard of clinical care recommends beginning chemoradiation within 6 weeks of…”
Get full text

β2‐Glycoprotein I binds to thrombin and selectively inhibits the enzyme procoagulant functions by Pozzi, N., Acquasaliente, L., Frasson, R., Cristiani, A., Moro, S., Banzato, A., Pengo, V., Scaglione, G. L., Arcovito, A., Cristofaro, R., Filippis, V.

“…Summary Background This work was aimed at characterizing the interaction of β2‐glycoprotein I (β2GPI), an abundant plasma protein of unknown function, with…”
Get full text

Platelet reactive conformation and multimeric pattern of von Willebrand factor in acquired thrombotic thrombocytopenic purpura during acute disease and remission by LOTTA, L. A., LOMBARDI, R., MARIANI, M., LANCELLOTTI, S., DE CRISTOFARO, R., HOLLESTELLE, M. J., CANCIANI, M. T., MANNUCCI, P. M., PEYVANDI, F.

“…Background: Binding of von Willebrand factor (VWF) multimers of ultra‐large size to platelets is considered the triggering mechanism of microvascular…”
Get full text

Measurement of plasma fibrinogen concentration by the prothrombin-time-derived method: applicability and limitations by De Cristofaro, R, Landolfi, R

“…A prothrombin-time-derived method was used to measure plasma fibrinogen concentration (PFC) in 286 samples from 242 normal and 44 orally anticoagulated…”
Get more information

Oxidized von Willebrand factor is efficiently cleaved by serine proteases from primary granules of leukocytes: divergence from ADAMTS‐13 by LANCELLOTTI, S., DE FILIPPIS, V., POZZI, N., OGGIANU, L., RUTELLA, S., SCAGLIONE, G. L., MASET, F., PEYVANDI, F., MANNUCCI, P. M., DE CRISTOFARO, R.

“…To cite this article: Lancellotti S, De Filippis V, Pozzi N, Oggianu L, Rutella S, Scaglione GL, Maset F, Peyvandi F, Mannucci PM, De Cristofaro R. Oxidized…”
Get full text

The type 2B p.R1306W natural mutation of von Willebrand factor dramatically enhances the multimer sensitivity to shear stress by Scaglione, G. L., Lancellotti, S., Papi, M., Spirito, M., Maiorana, A., Baronciani, L., Pagliari, M. T., Arcovito, A., Stasio, E., Peyvandi, F., Cristofaro, R.

“…Summary Background Shear stress triggers conformational stretching of von Willebrand factor (VWF), which is responsible for its self‐association and binding to…”
Get full text

Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets by Marino, M, Scuderi, F, Ponte, E, Maiuri, M T, De Cristofaro, R, Provenzano, C, Rose-John, S, Cittadini, A, Bartoccioni, E

“…Interleukin (IL)-6 is a multifunctional cytokine with a critical role in inflammatory, immunoregulatory and haemopoietic responses. Its receptor consists of an…”
Get more information

Role of Chloride Ions in Modulation of the Interaction between von Willebrand Factor and ADAMTS-13 by De Cristofaro, Raimondo, Peyvandi, Flora, Palla, Roberta, Lavoretano, Silvia, Lombardi, Rossana, Merati, Giuliana, Romitelli, Federica, Di Stasio, Enrico, Mannucci, Pier Mannuccio

“…The degradation of von Willebrand factor (VWF) depends on the activity of a zinc protease (referred to as ADAMTS-13), which cleaves VWF at the Tyr 1605 -Met…”
Get full text

Changes in Regional Cerebral Blood Flow Caused by Deep-Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease by Sestini, Stelvio, Scotto di Luzio, Anita, Ammannati, Franco, De Cristofaro, Maria Teresa R, Passeri, Alessandro, Martini, Sara, Pupi, Alberto

“…The aim of this study was to investigate the effect of deep-brain stimulation of the subthalamic nucleus (STN) on regional cerebral blood flow (rCBF)…”
Get full text

Polypharmacy in the elderly: A population based cross-sectional study in Lazio, Italy by Kirchmayer, U, Mayer, F, Basso, M, De Cristofaro, R, Mores, N, Cappai, G, Agabiti, N, Fusco, D, Davoli, M, Gambassi, G

“…Abstract Background Polypharmacy in the elderly is a matter of concern, especially regarding adverse events and drug–drug interactions. Little is known about…”
Get full text

Anticoagulation in ischaemic heart disease by De Cristofaro, R

“…[...]these patients received less frequently antiplatelet (aspirin and thienopyridines) drugs and heparin treatment in the acute phase, although, unexpectedly,…”
Get full text

Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus by De Cristofaro, R., Rocca, B., Vitacolonna, E., Falco, A., Marchesani, P., Ciabattoni, G., Landolfi, R., Patrono, C., Davì, G.

“…Diabetes mellitus (DM) is associated with enhanced lipid oxidation and persistent platelet activation. We investigated whether oxidant stress (OS) also affects…”
Get full text

Thrombin-induced platelet activation is inhibited by high- and low-molecular-weight heparin by DE CANDIA, E, DE CRISTOFARO, R, LANDOLFI, R

“…Thrombin binds to platelet glycoprotein Ib (Gp Ib), and this interaction contributes to platelet activation. Thrombin ligation to Gp Ib was recently shown to…”
Get full text

PO-31 Thrombin cleaves in vitro FGF-2 and modulates its biological activity by Totta, P, De Cristofaro, R, Capogrossi, M.C, Facchiano, A

Get full text

Structural and Functional Mapping of the Thrombin Domain Involved in the Binding to the Platelet Glycoprotein Ib by De Cristofaro, Raimondo, De Candia, Erica, Landolfi, Raffaele, Rutella, Sergio, Hall, Scott W

“…The activation of human platelets by α-thrombin is mediated in part by cleavage of the protease-activated receptor (PAR) 1 and 4 and by the glycoprotein Ibα,…”
Get full text