Search Results - "De Clercq, Sarah"

Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation In Vivo by De Clercq, Sarah, Gembarska, Agnieszka, Denecker, Geertrui, Maetens, Marion, Naessens, Michael, Haigh, Katharina, Haigh, Jody J, Marine, Jean-Christophe

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Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients by Remmelink, Myriam, De Mendonça, Ricardo, D'Haene, Nicky, De Clercq, Sarah, Verocq, Camille, Lebrun, Laetitia, Lavis, Philomène, Racu, Marie-Lucie, Trépant, Anne-Laure, Maris, Calliope, Rorive, Sandrine, Goffard, Jean-Christophe, De Witte, Olivier, Peluso, Lorenzo, Vincent, Jean-Louis, Decaestecker, Christine, Taccone, Fabio Silvio, Salmon, Isabelle

“…Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in…”
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Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death by Blanpain, Cédric, Denecker, Geertrui, Mascré, Guilhem, Candi, Aurélie, Marine, Jean-Christophe, Semeraro, Claudio, Youssef, Khalil Kass, Dahl, Ellen, Sotiropoulou, Panagiota A, De Clercq, Sarah, Lapouge, Gaelle

“…Hair follicle stem cells have increased resistance to DNA damage-induced cell death. This is due to higher expression of Bcl2 and to a faster non-homologous…”
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Expanding roles for the evolutionarily conserved Dmrt sex transcriptional regulators during embryogenesis by Bellefroid, Eric J., Leclère, Lucas, Saulnier, Amandine, Keruzore, Marc, Sirakov, Maria, Vervoort, Michel, De Clercq, Sarah

“…Dmrt genes encode a large family of transcription factors characterized by the presence of a DM domain, an unusual zinc finger DNA binding domain. While Dmrt…”
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L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages by De Clercq, Sarah, Boucherie, Ciska, Vandekerckhove, Joël, Gettemans, Jan, Guillabert, Aude

“…Podosomes are cellular structures acting as degradation 'hot-spots' in monocytic cells. They appear as dot-like structures at the ventral cell surface,…”
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The Role of SMAD4 Inactivation in Epithelial-Mesenchymal Plasticity of Pancreatic Ductal Adenocarcinoma: The Missing Link? by Racu, Marie-Lucie, Lebrun, Laetitia, Schiavo, Andrea Alex, Van Campenhout, Claude, De Clercq, Sarah, Absil, Lara, Minguijon Perez, Esmeralda, Maris, Calliope, Decaestecker, Christine, Salmon, Isabelle, D'Haene, Nicky

“…Pancreatic ductal adenocarcinoma (PDAC) presents a five-year survival rate of 10% and its incidence increases over the years. It is, therefore, essential to…”
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NTRK gene fusions in biliary tract cancers by Demols, Anne, Rocq, Laureen, Charry, Manon, De Nève, Nancy, Verrellen, Audrey, Ramadhan, Ali, Van Campenhout, Claude, De Clercq, Sarah, Salmon, Isabelle, D'Haene, Nicky

“…Abstract only 574 Background: Gene fusions involving one of the 3 neurotrophic tyrosine receptor kinases ( NTRK) have been identified in approximately 1% of…”
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Mdm4 and Mdm2 Cooperate to Inhibit p53 Activity in Proliferating and Quiescent Cells in vivo by Francoz, Sarah, Froment, Pascal, Bogaerts, Sven, De Clercq, Sarah, Maetens, Marion, Doumont, Gilles, Bellefroid, Eric, Marine, Jean-Christophe

“…The Mdm2 and Mdm4 oncoproteins are key negative regulators of the p53 tumor suppressor. However, their physiological contributions to the regulation of p53…”
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SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature by Lebrun, Laetitia, Absil, Lara, Remmelink, Myriam, De Mendonça, Ricardo, D'Haene, Nicky, Gaspard, Nicolas, Rusu, Stefan, Racu, Marie-Lucie, Collin, Amandine, Allard, Justine, Zindy, Egor, Schiavo, Andrea Alex, De Clercq, Sarah, De Witte, Olivier, Decaestecker, Christine, Lopes, Maria-Beatriz, Salmon, Isabelle

“…COVID-19-infected patients harbour neurological symptoms such as stroke and anosmia, leading to the hypothesis that there is direct invasion of the central…”
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The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals by Saulnier, Amandine, Keruzore, Marc, De Clercq, Sarah, Bar, Isabelle, Moers, Virginie, Magnani, Dario, Walcher, Tessa, Filippis, Carol, Kricha, Sadia, Parlier, Damien, Viviani, Laurène, Matson, Clinton K, Nakagawa, Yasushi, Theil, Thomas, Götz, Magdalena, Mallamaci, Antonello, Marine, Jean-Christophe, Zarkower, David, Bellefroid, Eric J

“…Regional patterning of the cerebral cortex is initiated by morphogens secreted by patterning centers that establish graded expression of transcription factors…”
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Evolutionarily Conserved Role of Nucleostemin: Controlling Proliferation of Stem/Progenitor Cells during Early Vertebrate Development by Beekman, Chantal, Nichane, Massimo, De Clercq, Sarah, Maetens, Marion, Floss, Thomas, Wurst, Wolfgang, Bellefroid, Eric, Marine, Jean-Christophe

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Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells by Nyabi, Omar, Naessens, Michael, Haigh, Katharina, Gembarska, Agnieszka, Goossens, Steven, Maetens, Marion, De Clercq, Sarah, Drogat, Benjamin, Haenebalcke, Lieven, Bartunkova, Sonia, De Vos, Ilse, De Craene, Bram, Karimi, Mansour, Berx, Geert, Nagy, Andras, Hilson, Pierre, Marine, Jean-Christophe, Haigh, Jody J.

“…The ability to rapidly and efficiently generate reliable Cre/loxP conditional transgenic mice would greatly complement global high-throughput gene targeting…”
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Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma by VAN MAERKEN, Tom, SPELEMAN, Frank, MARINE, Jean-Christophe, VANDESOMPELE, Jo, VERMEULEN, Joëlle, LAMBERTZ, Irina, DE CLERCQ, Sarah, DE SMET, Els, YIGIT, Nurten, COPPENS, Vicky, PHILIPPE, Jan, DE PAEPE, Anne

“…Circumvention of the p53 tumor suppressor barrier in neuroblastoma is rarely caused by TP53 mutation but might arise from inappropriately increased activity of…”
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Distinct roles of Mdm2 and Mdm4 in red cell production by Maetens, Marion, Doumont, Gilles, Clercq, Sarah De, Francoz, Sarah, Froment, Pascal, Bellefroid, Eric, Klingmuller, Ursula, Lozano, Guillermina, Marine, Jean-Christophe

“…Mdm2 and Mdm4 are critical negative regulators of the p53 tumor suppressor. Mdm4-null mutants are severely anemic and exhibit impaired proliferation of the…”
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Identification of the tumour transition states occurring during EMT by Pastushenko, Ievgenia, Brisebarre, Audrey, Sifrim, Alejandro, Fioramonti, Marco, Revenco, Tatiana, Boumahdi, Soufiane, Van Keymeulen, Alexandra, Brown, Daniel, Moers, Virginie, Lemaire, Sophie, De Clercq, Sarah, Minguijón, Esmeralda, Balsat, Cédric, Sokolow, Youri, Dubois, Christine, De Cock, Florian, Scozzaro, Samuel, Sopena, Federico, Lanas, Angel, D’Haene, Nicky, Salmon, Isabelle, Marine, Jean-Christophe, Voet, Thierry, Sotiropoulou, Panagiota A., Blanpain, Cédric

“…In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour stemness, metastasis and resistance to therapy. It has recently been…”
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Monitoring community antibiotic consumption in Belgium: reimbursement versus retail data (2013-22) by Damian, Elena, Bonacini, Laura, Kelly, Moira, Allaoui, El Maati, Maertens De Noordhout, Charline, Coenen, Samuel, Deckers, Ivo, De Clercq, Sarah, De Falleur, Marc, Versporten, Ann, Catry, Boudewijn, Catteau, Lucy

“…In Belgium, monitoring antibiotic consumption relies on reimbursement data, which is obtained with a time delay and does not account for over-the-counter or…”
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A Two-Step Diagnostic Approach for NTRK Gene Fusion Detection in Biliary Tract and Pancreatic Adenocarcinomas by Demols, Anne, Rocq, Laureen, Perez-Casanova, Luis, Charry, Manon, De Nève, Nancy, Ramadhan, Ali, Van Campenhout, Claude, De Clercq, Sarah, Maris, Calliope, Closset, Jean, Lucidi, Valerio, Salmon, Isabelle, D’Haene, Nicky

“…Abstract Background It is of interest to determine the incidence and molecular characteristics of NTRK gene fusions in patients with bilio-pancreatic cancers,…”
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DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors by Desmaris, Elodie, Keruzore, Marc, Saulnier, Amandine, Ratié, Leslie, Assimacopoulos, Stavroula, De Clercq, Sarah, Nan, Xinsheng, Roychoudhury, Kaushik, Qin, Shenyue, Kricha, Sadia, Chevalier, Clément, Lingner, Thomas, Henningfeld, Kristine A, Zarkower, David, Mallamaci, Antonello, Theil, Thomas, Campbell, Kenneth, Pieler, Tomas, Li, Meng, Grove, Elizabeth A, Bellefroid, Eric J

“…Specification of dorsoventral regional identity in progenitors of the developing telencephalon is a first pivotal step in the development of the cerebral…”
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Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation by De Clercq, Sarah, Zwaenepoel, Olivier, Martens, Evelien, Vandekerckhove, Joël, Guillabert, Aude, Gettemans, Jan

“…The T cell integrin receptor LFA-1 orchestrates adhesion between T cells and antigen-presenting cells (APCs), resulting in formation of a contact zone known as…”
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DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation by De Clercq, Sarah, Keruzore, Marc, Desmaris, Elodie, Pollart, Charlotte, Assimacopoulos, Stavroula, Preillon, Julie, Ascenzo, Sabrina, Matson, Clinton K, Lee, Melody, Nan, Xinsheng, Li, Meng, Nakagawa, Yasushi, Hochepied, Tino, Zarkower, David, Grove, Elizabeth A, Bellefroid, Eric J

“…Abstract Mice that are constitutively null for the zinc finger doublesex and mab-3 related (Dmrt) gene, Dmrt5/Dmrta2, show a variety of patterning…”
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