Search Results - "De Cauwer, Lode"

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα by Ratman, Dariusz, Mylka, Viacheslav, Bougarne, Nadia, Pawlak, Michal, Caron, Sandrine, Hennuyer, Nathalie, Paumelle, Réjane, De Cauwer, Lode, Thommis, Jonathan, Rider, Mark H, Libert, Claude, Lievens, Sam, Tavernier, Jan, Staels, Bart, De Bosscher, Karolien

“…Adaptation to fasting involves both Glucocorticoid Receptor (GRα) and Peroxisome Proliferator-Activated Receptor α (PPARα) activation. Given both receptors can…”
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The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages by Mylka, Viacheslav, Deckers, Julie, Ratman, Dariusz, De Cauwer, Lode, Thommis, Jonathan, De Rycke, Riet, Impens, Francis, Libert, Claude, Tavernier, Jan, Vanden Berghe, Wim, Gevaert, Kris, De Bosscher, Karolien

“…Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis,…”
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Sin3a repressor complex is a master regulator of STAT transcriptional activity by Icardi, Laura, Mori, Raffaele, Gesellchen, Viola, Eyckerman, Sven, De Cauwer, Lode, Verhelst, Judith, Vercauteren, Koen, Saelens, Xavier, Meuleman, Philip, Leroux-Roels, Geert, De Bosscher, Karolien, Boutros, Michael, Tavernier, Jan

“…Tyrosine phosphorylation is a hallmark for activation of STAT proteins, but their transcriptional activity also depends on other secondary modifications. Type…”
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A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment by Cauwels, Anje, Van Lint, Sandra, Garcin, Geneviève, Bultinck, Jennyfer, Paul, Franciane, Gerlo, Sarah, Van der Heyden, José, Bordat, Yann, Catteeuw, Dominiek, De Cauwer, Lode, Rogge, Elke, Verhee, Annick, Uzé, Gilles, Tavernier, Jan

“…Despite approval for the treatment of various malignancies, clinical application of cytokines such as type I interferon (IFN) is severely impeded by their…”
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The nature of the GRE influences the screening for GR-activity enhancing modulators by Dendoncker, Karen, Timmermans, Steven, Van Looveren, Kelly, De Cauwer, Lode, De Bosscher, Karolien, Libert, Claude

“…Glucocorticoid resistance (GCR), i.e. unresponsiveness to the beneficial anti-inflammatory activities of the glucocorticoid receptor (GR), poses a serious…”
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TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity by Mori, Raffaele, Wauman, Joris, Icardi, Laura, Van der Heyden, José, De Cauwer, Lode, Peelman, Frank, De Bosscher, Karolien, Tavernier, Jan

“…STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and…”
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Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses by Bougarne, Nadia, Mylka, Viacheslav, Ratman, Dariusz, Beck, Ilse M, Thommis, Jonathan, De Cauwer, Lode, Tavernier, Jan, Staels, Bart, Libert, Claude, De Bosscher, Karolien

“…Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide…”
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Opposed regulation of type I IFN‐induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2 by Icardi, Laura, Lievens, Sam, Mori, Raffaele, Piessevaux, Julie, De Cauwer, Lode, De Bosscher, Karolien, Tavernier, Jan

“…ABSTRACT The antiviral and antiproliferative responses mediated by type I interferons (IFNs) depend on JAK/STAT signaling and ISGF3 (STAT1:STAT2:…”
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Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression by Desmet, Sofie J., Thommis, Jonathan, Vanderhaeghen, Tineke, Vandenboorn, Edmee M.F., Clarisse, Dorien, Li, Yunkun, Timmermans, Steven, Fijalkowska, Daria, Ratman, Dariusz, Van Hamme, Evelien, De Cauwer, Lode, Staels, Bart, Brunsveld, Luc, Peelman, Frank, Libert, Claude, Tavernier, Jan, De Bosscher, Karolien

“…The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent…”
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Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor by Petta, Ioanna, Bougarne, Nadia, Vandewalle, Jolien, Dejager, Lien, Vandevyver, Sofie, Ballegeer, Marlies, Desmet, Sofie, Thommis, Jonathan, De Cauwer, Lode, Lievens, Sam, Libert, Claude, Tavernier, Jan, De Bosscher, Karolien

“…The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here…”
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Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK by Zielińska, Karolina A, de Cauwer, Lode, Knoops, Sofie, Van der Molen, Kristof, Sneyers, Alexander, Thommis, Jonathan, De Souza, J Brian, Opdenakker, Ghislain, De Bosscher, Karolien, Van den Steen, Philippe E

“…Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome…”
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PS1-019. Opposite regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2 by Icardi, Laura, Bosscher, Karolien De, Mori, Raffaele, Cauwer, Lode De, Lievens, Sam, Tavernier, Jan

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Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice by Thoonen, Robrecht, Cauwels, Anje, Decaluwe, Kelly, Geschka, Sandra, Tainsh, Robert E., Delanghe, Joris, Hochepied, Tino, De Cauwer, Lode, Rogge, Elke, Voet, Sofie, Sips, Patrick, Karas, Richard H., Bloch, Kenneth D., Vuylsteke, Marnik, Stasch, Johannes-Peter, Van de Voorde, Johan, Buys, Emmanuel S., Brouckaert, Peter

“…Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its…”
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Co-Activation of Glucocorticoid Receptor and Peroxisome Proliferator–Activated Receptor-γ in Murine Skin Prevents Worsening of Atopic March by Deckers, Julie, Bougarne, Nadia, Mylka, Viacheslav, Desmet, Sofie, Luypaert, Astrid, Devos, Michael, Tanghe, Giel, Van Moorleghem, Justine, Vanheerswynghels, Manon, De Cauwer, Lode, Thommis, Jonathan, Vuylsteke, Marnik, Tavernier, Jan, Lambrecht, Bart N., Hammad, Hamida, De Bosscher, Karolien

“…Children with atopic dermatitis show an increased risk to develop asthma later in life, a phenomenon referred to as “atopic march,” which emphasizes the need…”
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Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development by Baetens, Dorien, Güran, Tülay, Mendonca, Berenice B., Gomes, Nathalia L., De Cauwer, Lode, Peelman, Frank, Verdin, Hannah, Vuylsteke, Marnik, Van der Linden, Malaïka, Stoop, Hans, Looijenga, Leendert H., De Bosscher, Karolien, Cools, Martine, De Baere, Elfride, Atay, Zeynep, Bereket, Abdullah, de Krijger, Ronald R., Preter, Katleen de, Domenice, Sorahia, Turan, Serap

“…Disorders or differences of sex development (DSDs) are rare congenital conditions characterized by atypical sex development. Despite advances in genomic…”
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A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma by Reber, Laurent L, Daubeuf, François, Plantinga, Maud, De Cauwer, Lode, Gerlo, Sarah, Waelput, Wim, Van Calenbergh, Serge, Tavernier, Jan, Haegeman, Guy, Lambrecht, Bart N, Frossard, Nelly, De Bosscher, Karolien

“…The glucocorticoid receptor (GR) is a transcription factor able to support either target gene activation via direct binding to DNA or gene repression via…”
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Co-activation of GR and PPARγ in murine skin prevents worsening of atopic march by Deckers, Julie, Bougarne, Nadia, Mylka, Viacheslav, Desmet, Sofie, Luypaert, Astrid, Devos, Michael, Tanghe, Giel, Van Moorleghem, Justine, Vanheerswynghels, Manon, De Cauwer, Lode, Thommis, Jonathan, Vuylsteke, Marnik, Tavernier, Jan, Lambrecht, Bart, Hammad, Hamida, De Bosscher, Karolien

“…Children with atopic dermatitis (AD) show an increased risk to develop asthma later in life, a phenomenon referred to as ‘atopic march’, which emphasizes the…”
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Oral 2022-2 - Heme-deficient NO-unresponsive sGC knock-in mice: Novel aspects of NO–sGC signaling in cardiovascular (patho)physiology by Robrecht, T., Emmanuel, Buys, Cauwels, Anje, Decaluwe, Kelly, Geschka, Sandra, Tainsh, Robert, Delanghe, Joris, Hochepied, Tino, De Cauwer, Lode, Rogge, Elke, Sips, Patrick, Karas, Richard, Bloch, Kenneth, Van De Voorde, Johan, Stasch, Johannes-Peter, Vuylsteke, Marnik, Brouckaert, Peter

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Heme-deficient NO-unresponsive sGC knock-in mice: Novel aspects of NO–sGC signaling in cardiovascular (patho)physiology by Robrecht, T., Emmanuel, Buys, Cauwels, Anje, Decaluwe, Kelly, Geschka, Sandra, Tainsh, Robert, Delanghe, Joris, Hochepied, Tino, De Cauwer, Lode, Rogge, Elke, Sips, Patrick, Karas, Richard, Bloch, Kenneth, Van De Voorde, Johan, Stasch, Johannes-Peter, Vuylsteke, Marnik, Brouckaert, Peter

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