Search Results - "De Caestecker, Mark P."

BMPR2 mutations and endothelial dysfunction in pulmonary arterial hypertension (2017 Grover Conference Series) by Frump, Andrea, Prewitt, Allison, de Caestecker, Mark P.

“…Despite the discovery more than 15 years ago that patients with hereditary pulmonary arterial hypertension (HPAH) inherit BMP type 2 receptor (BMPR2)…”
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Experimental models of acute kidney injury for translational research by Hukriede, Neil A., Soranno, Danielle E., Sander, Veronika, Perreau, Tayla, Starr, Michelle C., Yuen, Peter S. T., Siskind, Leah J., Hutchens, Michael P., Davidson, Alan J., Burmeister, David M., Faubel, Sarah, de Caestecker, Mark P.

“…Preclinical models of human disease provide powerful tools for therapeutic discovery but have limitations. This problem is especially apparent in the field of…”
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Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux by Walker, Kenneth A, Sims-Lucas, Sunder, Di Giovanni, Valeria E, Schaefer, Caitlin, Sunseri, Whitney M, Novitskaya, Tatiana, de Caestecker, Mark P, Chen, Feng, Bates, Carlton M

“…Pax3cre-mediated deletion of fibroblast growth factor receptor 2 (Fgfr2) broadly in renal and urinary tract mesenchyme led to ureteric bud (UB) induction…”
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Low-grade albuminuria in pulmonary arterial hypertension by Nickel, Nils P., de Jesus Perez, Vinicio A., Zamanian, Roham T., Fessel, Joshua P., Cogan, Joy D., Hamid, Rizwam, West, James D., de Caestecker, Mark P., Yang, Haichun, Austin, Eric D.

“…Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with…”
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Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium by Naved, Bilal A, Bonventre, Joseph V, Hubbell, Jeffrey A, Hukriede, Neil A, Humphreys, Benjamin D, Kesselman, Carl, Valerius, M Todd, McMahon, Andrew P, Shankland, Stuart J, Wertheim, Jason A, White, Michael J V, de Caestecker, Mark P, Drummond, Iain A

“…Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney…”
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Histone Deacetylase Inhibitor Enhances Recovery after AKI by CIANCIOLO COSENTINO, Chiara, SKRYPNYK, Nataliya I, DAVIDSON, Alan J, HARRIS, Raymond C, DE CAESTECKER, Mark P, HUKRIEDE, Neil A, BRILLI, Lauren L, CHIBA, Takuto, NOVITSKAYA, Tatiana, WOODS, Clara, WEST, James, KOROTCHENKO, Vasiliy N, MCDERMOTT, Lee, DAY, Billy W

“…At present, there are no effective therapies to ameliorate injury, accelerate recovery, or prevent postinjury fibrosis after AKI. Here, we sought to identify…”
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Genotype-Phenotype Effects of Bmpr2 Mutations on Disease Severity in Mouse Models of Pulmonary Hypertension by Frump, Andrea L., Datta, Arunima, Ghose, Sampa, West, James, de Caestecker, Mark P.

“…More than 350 mutations in the type-2 BMP (bone morphogenetic protein) receptor, BMPR2, have been identified in patients with heritable pulmonary arterial…”
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Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI by Chiba, Takuto, Skrypnyk, Nataliya I, Skvarca, Lauren Brilli, Penchev, Radostin, Zhang, Ke Xin, Rochon, Elizabeth R, Fall, Jessica L, Paueksakon, Paisit, Yang, Haichun, Alford, Catherine E, Roman, Beth L, Zhang, Ming-Zhi, Harris, Raymond, Hukriede, Neil A, de Caestecker, Mark P

“…Retinoic acid (RA) has been used therapeutically to reduce injury and fibrosis in models of AKI, but little is known about the regulation of this pathway and…”
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Cell-free hemoglobin augments acute kidney injury during experimental sepsis by Shaver, Ciara M, Paul, Melinda G, Putz, Nathan D, Landstreet, Stuart R, Kuck, Jamie L, Scarfe, Lauren, Skrypnyk, Nataliya, Yang, Haichun, Harrison, Fiona E, de Caestecker, Mark P, Bastarache, Julie A, Ware, Lorraine B

“…Acute kidney injury is a common complication of severe sepsis and contributes to high mortality. The molecular mechanisms of acute kidney injury during sepsis…”
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A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injury by Novitskaya, Tatiana, McDermott, Lee, Zhang, Ke Xin, Chiba, Takuto, Paueksakon, Paisit, Hukriede, Neil A, de Caestecker, Mark P

“…Phenylthiobutanoic acids (PTBAs) are a new class of histone deacetylase (HDAC) inhibitors that accelerate recovery and reduce postinjury fibrosis after…”
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Multi-contrast computed tomography healthy kidney atlas by Lee, Ho Hin, Tang, Yucheng, Xu, Kaiwen, Bao, Shunxing, Fogo, Agnes B., Harris, Raymond, de Caestecker, Mark P., Heinrich, Mattias, Spraggins, Jeffrey M., Huo, Yuankai, Landman, Bennett A.

“…The construction of three-dimensional multi-modal tissue maps provides an opportunity to spur interdisciplinary innovations across temporal and spatial scales…”
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Heterozygous Null Bone Morphogenetic Protein Receptor Type 2 Mutations Promote SRC Kinase-dependent Caveolar Trafficking Defects and Endothelial Dysfunction in Pulmonary Arterial Hypertension by Prewitt, Allison R., Ghose, Sampa, Frump, Andrea L., Datta, Arumima, Austin, Eric D., Kenworthy, Anne K., de Caestecker, Mark P.

“…Hereditary pulmonary arterial hypertension (HPAH) is a rare, fatal disease of the pulmonary vasculature. The majority of HPAH patients inherit mutations in the…”
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Organ-Specific Defects in Insulin-Like Growth Factor and Insulin Receptor Signaling in Late Gestational Asymmetric Intrauterine Growth Restriction in Cited1 Mutant Mice by Novitskaya, Tatiana, Baserga, Mariana, de Caestecker, Mark P

“…Studies in Cited1 mutant mice identify organ-specific defects in IGF1R and IR signaling that may regulate asymmetric organ growth in late gestational placental…”
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Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension by Anderson, Lynda, Lowery, Jonathan W, Frank, David B, Novitskaya, Tatiana, Jones, Mark, Mortlock, Douglas P, Chandler, Ronald L, de Caestecker, Mark P

“…The bone morphogenetic protein (BMP) type 2 receptor ligand, Bmp2, is upregulated in the peripheral pulmonary vasculature during hypoxia-induced pulmonary…”
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Kidney regeneration: common themes from the embryo to the adult by Cirio, M. Cecilia, de Groh, Eric D., de Caestecker, Mark P., Davidson, Alan J., Hukriede, Neil A.

“…The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid…”
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Bone Morphogenetic Protein 4 Promotes Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension by Frank, David B, Abtahi, Amir, Yamaguchi, D J, Manning, Suzanne, Shyr, Yu, Pozzi, Ambra, Baldwin, H Scott, Johnson, Joyce E, de Caestecker, Mark P

“…We show that 1 of the type II bone morphogenetic protein (BMP) receptor ligands, BMP4, is widely expressed in the adult mouse lung and is upregulated in…”
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Correction: Deletion of Fibroblast Growth Factor Receptor 2 from the Peri-Wolffian Duct Stroma Leads to Ureteric Induction Abnormalities and Vesicoureteral Reflux by Walker, Kenneth A, Sims-Lucas, Sunder, Di Giovanni, Valeria E, Schaefer, Caitlin, Sunseri, Whitney M, Novitskaya, Tatiana, de Caestecker, Mark P, Chen, Feng, Bates, Carlton M

“…[This corrects the article DOI: 10.1371/journal.pone.0056062.]…”
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ID family protein expression and regulation in hypoxic pulmonary hypertension by Lowery, Jonathan W, Frump, Andrea L, Anderson, Lynda, DiCarlo, Gabriella E, Jones, Mark T, de Caestecker, Mark P

“…Bone morphogenetic protein (BMP) signaling has been linked to the development of pulmonary hypertension (PH). Inhibitors of differentiation (ID) proteins…”
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Capillary rarefaction is more closely associated with CKD progression after cisplatin, rhabdomyolysis, and ischemia-reperfusion-induced AKI than renal fibrosis by Menshikh, Anna, Scarfe, Lauren, Delgado, Rachel, Finney, Charlene, Zhu, Yuantee, Yang, Haichun, de Caestecker, Mark P

“…Acute kidney injury (AKI) is a strong independent predictor of mortality and often results in incomplete recovery of renal function, leading to progressive…”
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CITED1 Expression in Liver Development and Hepatoblastoma by Murphy, Andrew J, de Caestecker, Christian, Pierce, Janene, Boyle, Scott C, Ayers, Gregory D, Zhao, Zhiguo, Libes, Jaime M, Correa, Hernan, Walter, Teagan, Huppert, Stacey S, Perantoni, Alan O, de Caestecker, Mark P, Lovvorn, Harold N

“…Hepatoblastoma, the most common pediatric liver cancer, consists of epithelial mixed embryonal/fetal (EMEF) and pure fetal histologic subtypes, with the latter…”
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