Search Results - "De Cabo, Rafael"

Effects of Intermittent Fasting on Health, Aging, and Disease by de Cabo, Rafael, Mattson, Mark P

“…Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with…”
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A time to fast by Di Francesco, Andrea, Di Germanio, Clara, Bernier, Michel, de Cabo, Rafael

“…Nutrient composition and caloric intake have traditionally been used to devise optimized diets for various phases of life. Adjustment of meal size and…”
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The Search for Antiaging Interventions: From Elixirs to Fasting Regimens by de Cabo, Rafael, Carmona-Gutierrez, Didac, Bernier, Michel, Hall, Michael N., Madeo, Frank

“…The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial…”
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The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance by Lee, Changhan, Zeng, Jennifer, Drew, Brian G., Sallam, Tamer, Martin-Montalvo, Alejandro, Wan, Junxiang, Kim, Su-Jeong, Mehta, Hemal, Hevener, Andrea L., de Cabo, Rafael, Cohen, Pinchas

“…Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open…”
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Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise by Mera, Paula, Laue, Kathrin, Ferron, Mathieu, Confavreux, Cyril, Wei, Jianwen, Galán-Díez, Marta, Lacampagne, Alain, Mitchell, Sarah J., Mattison, Julie A., Chen, Yun, Bacchetta, Justine, Szulc, Pawel, Kitsis, Richard N., de Cabo, Rafael, Friedman, Richard A., Torsitano, Christopher, McGraw, Timothy E., Puchowicz, Michelle, Kurland, Irwin, Karsenty, Gerard

“…Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic exercise at the time levels of insulin decrease. In contrast,…”
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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging by Gomes, Ana P., Price, Nathan L., Ling, Alvin J.Y., Moslehi, Javid J., Montgomery, Magdalene K., Rajman, Luis, White, James P., Teodoro, João S., Wrann, Christiane D., Hubbard, Basil P., Mercken, Evi M., Palmeira, Carlos M., de Cabo, Rafael, Rolo, Anabela P., Turner, Nigel, Bell, Eric L., Sinclair, David A.

“…Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities,…”
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SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function by Price, Nathan L., Gomes, Ana P., Ling, Alvin J.Y., Duarte, Filipe V., Martin-Montalvo, Alejandro, North, Brian J., Agarwal, Beamon, Ye, Lan, Ramadori, Giorgio, Teodoro, Joao S., Hubbard, Basil P., Varela, Ana T., Davis, James G., Varamini, Behzad, Hafner, Angela, Moaddel, Ruin, Rolo, Anabela P., Coppari, Roberto, Palmeira, Carlos M., de Cabo, Rafael, Baur, Joseph A., Sinclair, David A.

“…Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To…”
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Reduced Expression of MYC Increases Longevity and Enhances Healthspan by Hofmann, Jeffrey W., Zhao, Xiaoai, De Cecco, Marco, Peterson, Abigail L., Pagliaroli, Luca, Manivannan, Jayameenakshi, Hubbard, Gene B., Ikeno, Yuji, Zhang, Yongqing, Feng, Bin, Li, Xiaxi, Serre, Thomas, Qi, Wenbo, Van Remmen, Holly, Miller, Richard A., Bath, Kevin G., de Cabo, Rafael, Xu, Haiyan, Neretti, Nicola, Sedivy, John M.

“…MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit…”
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Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition by Pomatto-Watson, Laura C. D., Bodogai, Monica, Bosompra, Oye, Kato, Jonathan, Wong, Sarah, Carpenter, Melissa, Duregon, Eleonora, Chowdhury, Dolly, Krishna, Priya, Ng, Sandy, Ragonnaud, Emeline, Salgado, Roberto, Gonzalez Ericsson, Paula, Diaz-Ruiz, Alberto, Bernier, Michel, Price, Nathan L., Biragyn, Arya, Longo, Valter D., de Cabo, Rafael

“…Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer…”
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A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome by Scheibye-Knudsen, Morten, Mitchell, Sarah J., Fang, Evandro F., Iyama, Teruaki, Ward, Theresa, Wang, James, Dunn, Christopher A., Singh, Nagendra, Veith, Sebastian, Hasan-Olive, Md Mahdi, Mangerich, Aswin, Wilson, Mark A., Mattson, Mark P., Bergersen, Linda H., Cogger, Victoria C., Warren, Alessandra, Le Couteur, David G., Moaddel, Ruin, Wilson, David M., Croteau, Deborah L., de Cabo, Rafael, Bohr, Vilhelm A.

“…Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair…”
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Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors by Kim, Ha-Neui, Ponte, Filipa, Nookaew, Intawat, Ucer Ozgurel, Serra, Marques-Carvalho, Adriana, Iyer, Srividhya, Warren, Aaron, Aykin-Burns, Nukhet, Krager, Kimberly, Sardao, Vilma A., Han, Li, de Cabo, Rafael, Zhao, Haibo, Jilka, Robert L., Manolagas, Stavros C., Almeida, Maria

“…Loss of estrogens at menopause is a major cause of osteoporosis and increased fracture risk. Estrogens protect against bone loss by decreasing osteoclast…”
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The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet by Mitchell, Sarah J., Martin-Montalvo, Alejandro, Mercken, Evi M., Palacios, Hector H., Ward, Theresa M., Abulwerdi, Gelareh, Minor, Robin K., Vlasuk, George P., Ellis, James L., Sinclair, David A., Dawson, John, Allison, David B., Zhang, Yongqing, Becker, Kevin G., Bernier, Michel, de Cabo, Rafael

“…The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care…”
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Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates by Mattison, Julie A., Wang, Mingyi, Bernier, Michel, Zhang, Jing, Park, Sung-Soo, Maudsley, Stuart, An, Steven S., Santhanam, Lakshmi, Martin, Bronwen, Faulkner, Shakeela, Morrell, Christopher, Baur, Joseph A., Peshkin, Leonid, Sosnowska, Danuta, Csiszar, Anna, Herbert, Richard L., Tilmont, Edward M., Ungvari, Zoltan, Pearson, Kevin J., Lakatta, Edward G., de Cabo, Rafael

“…Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity…”
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Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice by Allard, Joanne S., Perez, Evelyn J., Fukui, Koji, Carpenter, Priscilla, Ingram, Donald K., Cabo, Rafael de

“…•A mouse model was used to determine the effect of high fat diet and metformin treatment on cognition, brain neurotrophic factor expression and Nrf2…”
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Hepatic HuR modulates lipid homeostasis in response to high-fat diet by Zhang, Zhuojun, Zong, Chen, Jiang, Mingyang, Hu, Han, Cheng, Xiaolei, Ni, Juhua, Yi, Xia, Jiang, Bin, Tian, Feng, Chang, Ming-Wen, Su, Wen, Zhu, Lijun, Li, Jinfan, Xiang, Xueping, Miao, Congxiu, Gorospe, Myriam, de Cabo, Rafael, Dou, Yali, Ju, Zhenyu, Yang, Jichun, Jiang, Changtao, Yang, Zhongzhou, Wang, Wengong

“…Lipid transport and ATP synthesis are critical for the progression of non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms are largely…”
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Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice by Solon-Biet, Samantha M., Mitchell, Sarah J., Coogan, Sean C.P., Cogger, Victoria C., Gokarn, Rahul, McMahon, Aisling C., Raubenheimer, David, de Cabo, Rafael, Simpson, Stephen J., Le Couteur, David G.

“…Both caloric restriction (CR) and low-protein, high-carbohydrate (LPHC) ad-libitum-fed diets increase lifespan and improve metabolic parameters such as…”
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A Regulatory Role for MicroRNA 33 in Controlling Lipid Metabolism Gene Expression by Goedeke, Leigh, Vales-Lara, Frances M, Fenstermaker, Michael, Cirera-Salinas, Daniel, Chamorro-Jorganes, Aranzazu, Ramírez, Cristina M, Mattison, Julie A, de Cabo, Rafael, Suárez, Yajaira, Fernández-Hernando, Carlos

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway by Ashrafian, Houman, Czibik, Gabor, Bellahcene, Mohamed, Aksentijević, Dunja, Smith, Anthony C., Mitchell, Sarah J., Dodd, Michael S., Kirwan, Jennifer, Byrne, Jonathan J., Ludwig, Christian, Isackson, Henrik, Yavari, Arash, Støttrup, Nicolaj B., Contractor, Hussain, Cahill, Thomas J., Sahgal, Natasha, Ball, Daniel R., Birkler, Rune I.D., Hargreaves, Iain, Tennant, Daniel A., Land, John, Lygate, Craig A., Johannsen, Mogens, Kharbanda, Rajesh K., Neubauer, Stefan, Redwood, Charles, de Cabo, Rafael, Ahmet, Ismayil, Talan, Mark, Günther, Ulrich L., Robinson, Alan J., Viant, Mark R., Pollard, Patrick J., Tyler, Damian J., Watkins, Hugh

“…The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective; however, its mechanisms of action remain to be determined. To augment…”
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Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet by Jimenez-Gomez, Yolanda, Mattison, Julie A., Pearson, Kevin J., Martin-Montalvo, Alejandro, Palacios, Hector H., Sossong, Alex M., Ward, Theresa M., Younts, Caitlin M., Lewis, Kaitlyn, Allard, Joanne S., Longo, Dan L., Belman, Jonathan P., Malagon, Maria M., Navas, Placido, Sanghvi, Mitesh, Moaddel, Ruin, Tilmont, Edward M., Herbert, Richard L., Morrell, Christopher H., Egan, Josephine M., Baur, Joseph A., Ferrucci, Luigi, Bogan, Jonathan S., Bernier, Michel, de Cabo, Rafael

“…Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes…”
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A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice by Petr, Michael A, Alfaras, Irene, Krawcyzk, Melissa, Bair, Woei-Nan, Mitchell, Sarah J, Morrell, Christopher H, Studenski, Stephanie A, Price, Nathan L, Fishbein, Kenneth W, Spencer, Richard G, Scheibye-Knudsen, Morten, Lakatta, Edward G, Ferrucci, Luigi, Aon, Miguel A, Bernier, Michel, de Cabo, Rafael

“…Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits…”
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