Search Results - "De Boer, Onno J."

Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease by Cortjens, Bart, de Boer, Onno J, de Jong, Rineke, Antonis, Adriaan FG, Sabogal Piñeros, Yanaika S, Lutter, René, van Woensel, Job BM, Bem, Reinout A

“…Human respiratory syncytial virus (RSV) is the most important cause of severe lower respiratory tract disease (LRTD) in young children worldwide. Extensive…”
Get full text

The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato by Coumou, Jeroen, Wagemakers, Alex, Narasimhan, Sukanya, Schuijt, Tim J., Ersoz, Jasmin I., Oei, Anneke, de Boer, Onno J., Roelofs, Joris J. T. H., Fikrig, Erol, Hovius, Joppe W.

“…The causative agents of Lyme borreliosis, spirochetes belonging to the Borrelia burgdorferi sensu lato group, have developed several ways to protect themselves…”
Get full text

Extracellular traps derived from macrophages, mast cells, eosinophils and neutrophils are generated in a time‐dependent manner during atherothrombosis by Pertiwi, Kartika R, de Boer, Onno J, Mackaaij, Claire, Pabittei, Dara R, de Winter, Robbert J, Li, Xiaofei, van der Wal, Allard C

“…Extracellular traps generated by neutrophils contribute to thrombus progression in coronary atherosclerotic plaques. It is not known whether other inflammatory…”
Get full text

Deep learning for automatic Gleason pattern classification for grade group determination of prostate biopsies by Lucas, Marit, Jansen, Ilaria, Savci-Heijink, C. Dilara, Meijer, Sybren L., de Boer, Onno J., van Leeuwen, Ton G., de Bruin, Daniel M., Marquering, Henk A.

“…Histopathologic grading of prostate cancer using Gleason patterns (GPs) is subject to a large inter-observer variability, which may result in suboptimal…”
Get full text

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions by De Sousa E Melo, Felipe, Wang, Xin, Jansen, Marnix, Fessler, Evelyn, Trinh, Anne, de Rooij, Laura P M H, de Jong, Joan H, de Boer, Onno J, van Leersum, Ronald, Bijlsma, Maarten F, Rodermond, Hans, van der Heijden, Maartje, van Noesel, Carel J M, Tuynman, Jurriaan B, Dekker, Evelien, Markowetz, Florian, Medema, Jan Paul, Vermeulen, Louis

“…Analysis of gene-expression profiles led to the identification of three molecularly distinct subtypes of colon cancer. One of these subtypes is new, and its…”
Get full text

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae- Induced Pneumonia-Derived Sepsis by Claushuis, Theodora A M, van der Donk, Lieve E H, Luitse, Anna L, van Veen, Henk A, van der Wel, Nicole N, van Vught, Lonneke A, Roelofs, Joris J T H, de Boer, Onno J, Lankelma, Jacqueline M, Boon, Louis, de Vos, Alex F, van 't Veer, Cornelis, van der Poll, Tom

“…Peptidylarginine deiminase 4 (PAD4) catalyzes citrullination of histones, an important step for neutrophil extracellular trap (NET) formation. We aimed to…”
Get full text

Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia by de Porto, Alexander P, Liu, Zhe, de Beer, Regina, Florquin, Sandrine, de Boer, Onno J, Hendriks, Rudi W, van der Poll, Tom, de Vos, Alex F

“…Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia…”
Get full text

Deep Learning for Histopathological Assessment of Esophageal Adenocarcinoma Precursor Lesions by Botros, Michel, de Boer, Onno J., Cardenas, Bryan, Bekkers, Erik J., Jansen, Marnix, van der Wel, Myrtle J., Sánchez, Clara I., Meijer, Sybren L.

“…Histopathological assessment of esophageal biopsies is a key part in the management of patients with Barrett esophagus (BE) but prone to observer variability…”
Get full text

Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis by Res, Pieter C M, Piskin, Gamze, de Boer, Onno J, van der Loos, Chris M, Teeling, Peter, Bos, Jan D, Teunissen, Marcel B M

“…Although recent studies indicate a crucial role for IL-17A and IL-22 producing T cells in the pathogenesis of psoriasis, limited information is available on…”
Get full text

Microvascular proliferations in arteriovenous malformations relate to high-flow characteristics, inflammation, and previous therapeutic embolization of the lesion by Meijer-Jorna, Lorine B., MD, van der Loos, Chris M., PhD, de Boer, Onno J., PhD, Horrevoets, Anton J.G., PhD, Mekkes, Jan R., MD, PhD, van der Horst, Chantal M.A.M., MD, PhD, van der Wal, Allard C., MD, PhD

“…Background Episodes of microvascular proliferation associated with volume expansion have been observed in arteriovenous malformations (AVMs) of skin and soft…”
Get full text

Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques by de Boer, Onno J, van der Meer, Jelger J, Teeling, Peter, van der Loos, Chris M, Idu, Mirza M, van Maldegem, Febe, Aten, Jan, van der Wal, Allard C

“…In addition to the classical TH1 and TH2 cytokines, members of the recently identified IL-17 cytokine family play an important role in regulating cellular and…”
Get full text

Combining streptozotocin and unilateral nephrectomy is an effective method for inducing experimental diabetic nephropathy in the ‘resistant’ C57Bl/6J mouse strain by Uil, Melissa, Scantlebery, Angelique M. L., Butter, Loes M., Larsen, Per W. B., de Boer, Onno J., Leemans, Jaklien C., Florquin, Sandrine, Roelofs, Joris J. T. H.

“…Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Animal models are essential tools for designing new strategies to prevent DN. C57Bl/6…”
Get full text

Atherosclerosis in the circle of Willis: Spatial differences in composition and in distribution of plaques by Denswil, Nerissa P, van der Wal, Allard C, Ritz, Katja, de Boer, Onno J, Aronica, Eleonora, Troost, Dirk, Daemen, Mat J.A.P

“…Abstract Background and aims Intracranial atherosclerosis is one of the main causes of ischemic stroke. However, the characteristics of intracranial arteries…”
Get full text

Enrichment of type 1 innate lymphoid cells in the course of human atherosclerotic plaque development suggests contribution to atherogenesis by Pertiwi, Kartika R, Teunissen, Marcel B M, Krebbers, Gabrielle, Willems, Martine C M, Huisman, Laurens, Poelen, Cindy, van der Wal, Allard C, de Boer, Onno J

“…Innate lymphoid cells (ILCs) have been implicated in multiple pathologic conditions, including atherogenesis, as documented in experimental mice studies,…”
Get full text

Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions by de Boer, Onno J, van der Meer, Jelger J, Teeling, Peter, van der Loos, Chris M, van der Wal, Allard C

“…T cell mediated inflammation contributes to atherogenesis and the onset of acute cardiovascular disease. Effector T cell functions are under a tight control of…”
Get full text

ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice by Lieshout, Miriam H.P., Vos, Alex F., Dessing, Mark C., Porto, Alexander P.N.A., Boer, Onno J., Beer, Regina, Terpstra, Sanne, Florquin, Sandrine, van't Veer, Cornelis, der Poll, Tom

“…Streptococcus (S.) pneumoniae is the most common cause of community‐acquired pneumonia. The Nod‐like receptor family pyrin domain containing 3 (NLRP3)…”
Get full text

Bruton's Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia by de Porto, Alexander P, Liu, Zhe, de Beer, Regina, Florquin, Sandrine, Roelofs, Joris J T H, de Boer, Onno J, den Haan, Joke M M, Hendriks, Rudi W, van 't Veer, Cornelis, van der Poll, Tom, de Vos, Alex F

“…Bruton's tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural…”
Get full text

Bruton’s Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae by Liu, Zhe, De Porto, Alexander P.N.A., De Beer, Regina, Roelofs, Joris J.T.H., De Boer, Onno J., Florquin, Sandrine, Van’t Veer, Cornelis, Hendriks, Rudi W., Van der Poll, Tom, De Vos, Alex F.

“…Abstract Humans with dysfunctional Bruton’s tyrosine kinase (Btk) are highly susceptible to bacterial infections. Compelling evidence indicates that Btk is…”
Get full text

Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice by Daan de Boer, J, Roelofs, Joris J T H, de Vos, Alex F, de Beer, Regina, Schouten, Marcel, Hommes, Tijmen J, Hoogendijk, Arie J, de Boer, Onno J, Stroo, Ingrid, van der Zee, Jaring S, Veer, Cornelis Van't, van der Poll, Tom

“…The complex biology of asthma compels the use of more relevant human allergens, such as house dust mite (HDM), to improve the translation of animal models into…”
Get full text

Myeloid-related protein-14 deficiency promotes inflammation in staphylococcal pneumonia by Achouiti, Ahmed, Vogl, Thomas, Van der Meer, Anne J, Stroo, Ingrid, Florquin, Sandrine, de Boer, Onno J, Roth, Johannes, Zeerleder, Sacha, van 't Veer, Cornelis, de Vos, Alex F, van der Poll, Tom

“…Staphylococcus aureus has evolved as an important cause of pneumonia in both hospital and community settings. Staphylococcal lung infection can lead to…”
Get full text