Search Results - "De Boeck, Marlies"

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results by Uno, Yoshifumi, Kojima, Hajime, Omori, Takashi, Corvi, Raffaella, Honma, Masamistu, Schechtman, Leonard M., Tice, Raymond R., Beevers, Carol, Boeck, Marlies De, Burlinson, Brian, Hobbs, Cheryl A., Kitamoto, Sachiko, Kraynak, Andrew R., McNamee, James, Nakagawa, Yuzuki, Pant, Kamala, Plappert-Helbig, Ulla, Priestley, Catherine, Takasawa, Hironao, Wada, Kunio, Wirnitzer, Uta, Asano, Norihide, Escobar, Patricia A., Lovell, David, Morita, Takeshi, Nakajima, Madoka, Ohno, Yasuo, Hayashi, Makoto

“…•JaCVAM organized an international validation study of in vivo rat comet assay.•The ultimate goal was to establish the OECD test guideline.•The assay…”
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Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al by Chen, Guang, Mannens, Geert, De Boeck, Marlies, Daly, Ella J., Canuso, Carla M., Teuns, Greet, Manji, Husseini, Drevets, Wayne C.

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Critical issues with the in vivo comet assay: A report of the comet assay working group in the 6th International Workshop on Genotoxicity Testing (IWGT) by Speit, Günter, Kojima, Hajime, Burlinson, Brian, Collins, Andrew R., Kasper, Peter, Plappert-Helbig, Ulla, Uno, Yoshifumi, Vasquez, Marie, Beevers, Carol, De Boeck, Marlies, Escobar, Patricia A., Kitamoto, Sachiko, Pant, Kamala, Pfuhler, Stefan, Tanaka, Jin, Levy, Dan D.

“…•The in vivo comet assay is a mature test for the evaluation of genotoxicity.•Recommendations for an appropriate use of the assay are given.•Laboratories…”
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Importance of detecting numerical versus structural chromosome aberrations by KIRSCH-VOLDERS, Micheline, VANHAUWAERT, Annelies, DE BOECK, Marlies, DECORDIER, Ilse

“…The aim is to review briefly the key questions related to aneuploidy/polyploidy and to compare the advantages and disadvantages of the in vitro micronucleus…”
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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites by Tichenor, Mark S., Keith, John M., Jones, William M., Pierce, Joan M., Merit, Jeff, Hawryluk, Natalie, Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark J., Wilson, Sandy J., Wennerholm, Michelle L., Woestenborghs, Filip, Beerens, Dominiek, Luo, Lin, Brown, Sean M., Boeck, Marlies De, Chaplan, Sandra R., Breitenbucher, J. Guy

“…The structure–activity relationships for a series of heteroaryl urea inhibitors of fatty acid amide hydrolase (FAAH) are described. Members of this class of…”
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Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay by Bryce, Steven M., Avlasevich, Svetlana L., Bemis, Jeffrey C., Lukamowicz, Magdalena, Elhajouji, Azeddine, Van Goethem, Freddy, De Boeck, Marlies, Beerens, Dominiek, Aerts, Hilde, Van Gompel, Jacky, Collins, Joanne E., Ellis, Patricia C., White, Angela T., Lynch, Anthony M., Dertinger, Stephen D.

“…An international, multi-lab trial was conducted to evaluate a flow cytometry-based method for scoring micronuclei in mouse lymphoma L5178Y cells [S.L…”
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Validation and implementation of an internal standard in comet assay analysis by De Boeck, Marlies, Touil, Nadia, De Visscher, Geofrey, Vande, Peter Aka, Kirsch-Volders, Micheline

“…The comet assay is widely used to detect DNA damage in single cells. However, only moderate attention has been paid to the experimental variability of this…”
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Evaluation of the apoptogenic potential of hard metal dust (WC–Co), tungsten carbide and metallic cobalt by Lombaert, Noömi, Boeck, Marlies De, Decordier, Ilse, Cundari, Enrico, Lison, Dominique, Kirsch-Volders, Micheline

“…The present study aimed at comparing in vitro the apoptogenic properties of metallic cobalt (Co), tungsten carbide (WC) and tungsten carbide–cobalt (WC–Co) in…”
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Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling by De Boeck, Marlies, van der Leede, Bas-jan, Van Goethem, Freddy, De Smedt, Ann, Steemans, Margino, Lampo, Ann, Vanparys, Philippe

“…According to the current Organization of Economic Cooperation and Development (OECD) and International Committee on Harmonization (ICH) guidelines for the…”
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Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies by Rothfuss, Andreas, O’Donovan, Mike, De Boeck, Marlies, Brault, Dominique, Czich, Andreas, Custer, Laura, Hamada, Shuichi, Plappert-Helbig, Ulla, Hayashi, Makoto, Howe, Jonathan, Kraynak, Andrew R., van der Leede, Bas-jan, Nakajima, Madoka, Priestley, Catherine, Thybaud, Veronique, Saigo, Kazuhiko, Sawant, Satin, Shi, Jing, Storer, Richard, Struwe, Melanie, Vock, Esther, Galloway, Sheila

“…A collaborative trial was conducted to evaluate the possibility of integrating the rat-liver Comet assay into repeat-dose toxicity studies. Fourteen…”
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Evaluation of p-phenylenediamine, o-phenylphenol sodium salt, and 2,4-diaminotoluene in the rat comet assay as part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay by De Boeck, Marlies, van der Leede, Bas-jan, De Vlieger, Kathleen, Geys, Helena, Vynckier, An, Van Gompel, Jacky

“…•Three coded compounds were evaluated in the in vivo rat alkaline comet assay.•Contribution to JaCVAM comet assay validation trial in rat liver and…”
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Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: Protocol optimization and transferability assessment by Bryce, Steven M., Avlasevich, Svetlana L., Bemis, Jeffrey C., Tate, Matthew, Walmsley, Richard M., Saad, Frédéric, Van Dijck, Kris, De Boeck, Marlies, Van Goethem, Freddy, Lukamowicz-Rajska, Magdalena, Elhajouji, Azeddine, Dertinger, Stephen D.

“…An automated approach for scoring in vitro micronuclei (MN) has been described in which flow cytometric analysis is combined with compound exposure,…”
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Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future by Avlasevich, Svetlana, Bryce, Steven, De Boeck, Marlies, Elhajouji, Azeddine, Van Goethem, Freddy, Lynch, Anthony, Nicolette, John, Shi, Jing, Dertinger, Stephen

“…The relative simplicity of the in vitro micronucleus (MNvit) endpoint has made it amenable to several automated scoring approaches. Flow cytometry is one such…”
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New and emerging technologies for genetic toxicity testing by Lynch, Anthony M, Sasaki, Jennifer C, Elespuru, Rosalie, Jacobson-Kram, David, Thybaud, Véronique, De Boeck, Marlies, Aardema, Marilyn J, Aubrecht, Jiri, Benz, R. Daniel, Dertinger, Stephen D, Douglas, George R, White, Paul A, Escobar, Patricia A, Fornace, Albert Jr, Honma, Masamitsu, Naven, Russell T, Rusling, James F, Schiestl, Robert H, Walmsley, Richard M, Yamamura, Eiji, van Benthem, Jan, Kim, James H

“…The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of…”
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A Bayesian, Generalized Frailty Model for Comet Assays by Ghebretinsae, Aklilu Habteab, Faes, Christel, Molenberghs, Geert, De Boeck, Marlies, Geys, Helena

“…This paper proposes a flexible modeling approach for so-called comet assay data regularly encountered in preclinical research. While such data consist of…”
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In vivo genotoxicity of hard metal dust: induction of micronuclei in rat type II epithelial lung cells by De Boeck, Marlies, Hoet, Peter, Lombaert, Noömi, Nemery, Benoit, Kirsch-Volders, Micheline, Lison, Dominique

“…Inhalation of hard metal dust (WC-Co particles) has been associated with an increased risk for lung cancer in occupational settings. In vitro, WC-Co was…”
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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structureamutagenicity relationships for arylamine metabolites by Tichenor, Mark S, Keith, John M, Jones, William M, Pierce, Joan M, Merit, Jeff, Hawryluk, Natalie, Seierstad, Mark, Palmer, James A, Webb, Michael, Karbarz, Mark J, Wilson, Sandy J, Wennerholm, Michelle L, Woestenborghs, Filip, Beerens, Dominiek, Luo, Lin, Brown, Sean M, Boeck, Marlies De, Chaplan, Sandra R, Breitenbucher, JGuy

“…The structure-activity relationships for a series of heteroaryl urea inhibitors of fatty acid amide hydrolase (FAAH) are described. Members of this class of…”
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Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells by De Smedt, Ann, Steemans, Margino, De Boeck, Marlies, Peters, Annelieke K., van der Leede, Bas-jan, Van Goethem, Freddy, Lampo, Ann, Vanparys, Philippe

“…In order to support drug research in the selection process for non-embryotoxic pharmaceutical compounds, a screening method for embryotoxicity is needed. The…”
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Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers by Godderis, Lode, De Boeck, Marlies, Haufroid, Vincent, Emmery, Muriel, Mateuca, Raluca, Gardinal, Sophie, Kirsch-Volders, Micheline, Veulemans, Hendrik, Lison, Dominique

“…A study on 44 workers exposed to styrene and 44 matched referents was performed in order to examine the influence of genetic polymorphisms in biotransformation…”
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Evaluation of the in vitro direct and indirect genotoxic effects of cobalt compounds using the alkaline comet assay. Influence of interdonor and interexperimental variability by DE BOECK, M, LISON, D, KIRSCH-VOLDERS, M

“…The mechanisms of cobalt-induced pulmonary interstitial fibrosis and cancer are incompletely understood. DNA damage, either induced by genotoxic (direct or via…”
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