Search Results - "De Bock, Frederic"

Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature by Klement, Wendy, Garbelli, Rita, Zub, Emma, Rossini, Laura, Tassi, Laura, Girard, Benoit, Blaquiere, Marine, Bertaso, Federica, Perroy, Julie, de Bock, Frederic, Marchi, Nicola

“…Cerebrovascular dysfunction and inflammation occur in epilepsy. Here we asked whether pericytes, a pivotal cellular component of brain capillaries, undergo…”
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Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier by Clé, Marion, Desmetz, Caroline, Barthelemy, Jonathan, Martin, Marie-France, Constant, Orianne, Maarifi, Ghizlane, Foulongne, Vincent, Bolloré, Karine, Glasson, Yaël, De Bock, Frédéric, Blaquiere, Marine, Dehouck, Lucie, Pirot, Nelly, Tuaillon, Edouard, Nisole, Sébastien, Najioullah, Fatiha, Van de Perre, Philippe, Cabié, André, Marchi, Nicola, Gosselet, Fabien, Simonin, Yannick, Salinas, Sara

“…Zika virus (ZIKV) can be associated with neurological impairment in children and adults. To reach the central nervous system, viruses have to cross the…”
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Epac mediates PACAP-dependent long-term depression in the hippocampus by Ster, Jeanne, De Bock, Frédéric, Bertaso, Federica, Abitbol, Karine, Daniel, Hervé, Bockaert, Joël, Fagni, Laurent

“…Extensive work has shown that activation of the cAMP-dependent protein kinase A (PKA) is crucial for long-term depression (LTD) of synaptic transmission in the…”
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Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca²⁺-dependent K⁺ channels in cerebellar neurons by Ster, Jeanne, De Bock, Frédéric, Guérineau, Nathalie C, Janossy, Andrea, Barrère-Lemaire, Stéphanie, Bos, Johannes L, Bockaert, Joël, Fagni, Laurent

“…The exchange factor directly activated by cAMP (Epac) is a newly discovered direct target for cAMP and a guanine-nucleotide exchange factor for the small…”
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Redistribution of PDGFRβ cells and NG2DsRed pericytes at the cerebrovasculature after status epilepticus by Milesi, Sebastien, Boussadia, Badreddine, Plaud, Clement, Catteau, Matthias, Rousset, Marie-Claude, De Bock, Frederic, Schaeffer, Marie, Lerner-Natoli, Mireille, Rigau, Valerie, Marchi, Nicola

“…Abstract Purpose The role of cerebrovascular dysfunction in seizure disorders is recognized. Blood–brain barrier (BBB) damage in epilepsy has been linked to…”
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Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy by Boux, Fabien, Forbes, Florence, Collomb, Nora, Zub, Emma, Mazière, Lucile, Bock, Fréderic, Blaquiere, Marine, Stupar, Vasile, Depaulis, Antoine, Marchi, Nicola, Barbier, Emmanuel L.

“…Objective Improving the identification of the epileptogenic zone and associated seizure‐spreading regions represents a significant challenge. Innovative…”
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Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice by Smith, Lorraine, Klément, Wendy, Dopavogui, Léonie, de Bock, Frédéric, Lasserre, Frédéric, Barretto, Sharon, Lukowicz, Céline, Fougerat, Anne, Polizzi, Arnaud, Schaal, Benoist, Patris, Bruno, Denis, Colette, Feuillet, Guylène, Canlet, Cécile, Jamin, Emilien L, Debrauwer, Laurent, Mselli-Lakhal, Laila, Loiseau, Nicolas, Guillou, Hervé, Marchi, Nicola, Ellero-Simatos, Sandrine, Gamet-Payrastre, Laurence

“…We recently demonstrated that chronic dietary exposure to a mixture of pesticides at low-doses induced sexually dimorphic obesogenic and diabetogenic effects…”
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Machine Learning Analysis of the Cerebrovascular Thrombi Proteome in Human Ischemic Stroke: An Exploratory Study by Dargazanli, Cyril, Zub, Emma, Deverdun, Jeremy, Decourcelle, Mathilde, de Bock, Frédéric, Labreuche, Julien, Lefèvre, Pierre-Henri, Gascou, Grégory, Derraz, Imad, Riquelme Bareiro, Carlos, Cagnazzo, Federico, Bonafé, Alain, Marin, Philippe, Costalat, Vincent, Marchi, Nicola

“…Objective: Mechanical retrieval of thrombotic material from acute ischemic stroke patients provides a unique entry point for translational research…”
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Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies by Morin-Brureau, Mélanie, De Bock, Frédéric, Lerner-Natoli, Mireille

“…It is now recognized that the neuro-vascular unit (NVU) plays a key role in several neurological diseases including epilepsy, stroke, Alzheimer's disease,…”
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Loss of X-Linked Mental Retardation Gene Oligophrenin1 in Mice Impairs Spatial Memory and Leads to Ventricular Enlargement and Dendritic Spine Immaturity by Khelfaoui, Malik, Denis, Cecile, van Galen, Elly, de Bock, Frederic, Schmitt, Alain, Houbron, Christophe, Morice, Elise, Giros, Bruno, Ramakers, Ger, Fagni, Laurent, Chelly, Jamel, Nosten-Bertrand, Marika, Billuart, Pierre

“…Loss of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar hypoplasia and, in some cases, with lateral…”
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PICK1 uncoupling from mGluR7a causes absence-like seizures by Bockaert, Joël, Bertaso, Federica, Zhang, Chuansheng, Scheschonka, Astrid, de Bock, Frédéric, Fontanaud, Pierre, Marin, Philippe, Huganir, Richard L, Betz, Heinrich, Fagni, Laurent, Lerner-Natoli, Mireille

“…Mice lacking the metabotropic glutamate receptor mGluR7 are hypersensitive to convulsant drugs. But how does mGluR7 act to prevent seizures? Here the authors…”
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Increased number of neural progenitors in human temporal lobe epilepsy by Crespel, Arielle, Rigau, Valérie, Coubes, Philippe, Rousset, Marie Claude, de Bock, Frédéric, Okano, Hideyuki, Baldy-Moulinier, Michel, Bockaert, Joël, Lerner-Natoli, Mireille

“…An increased neurogenesis is reported in animal models of mesial temporal lobe epilepsy (MTLE) but the fate of newborn cells is unknown. Here, we attempted to…”
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Differential impact of dose-range glyphosate on locomotor behavior, neuronal activity, glio-cerebrovascular structures, and transcript regulations in zebrafish larvae by Forner-Piquer, Isabel, Faucherre, Adèle, Byram, Julia, Blaquiere, Marine, de Bock, Frederic, Gamet-Payrastre, Laurence, Ellero-Simatos, Sandrine, Audinat, Etienne, Jopling, Chris, Marchi, Nicola

“…The presence of glyphosate represents a debated ecotoxicological and health risk factor. Here, zebrafish larvae were exposed, from 1.5 to 120 h…”
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The GR‐ANXA1 pathway is a pathological player and a candidate target in epilepsy by Zub, Emma, Canet, Geoffrey, Garbelli, Rita, Blaquiere, Marine, Rossini, Laura, Pastori, Chiara, Sheikh, Madeeha, Reutelingsperger, Chris, Klement, Wendy, Bock, Frederic, Audinat, Etienne, Givalois, Laurent, Solito, Egle, Marchi, Nicola

“…Immune changes occur in experimental and clinical epilepsy. Here, we tested the hypothesis that during epileptogenesis and spontaneous recurrent seizures (SRS)…”
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A presynaptic role of microtubule-associated protein 1/Futsch in Drosophila: regulation of active zone number and neurotransmitter release by Lepicard, Simon, Franco, Bénédicte, de Bock, Frédéric, Parmentier, Marie-Laure

“…Structural microtubule-associated proteins (MAPs), like MAP1, not only control the stability of microtubules, but also interact with postsynaptic proteins in…”
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Cerebrovascular heterogeneity and neuronal excitability by Librizzi, Laura, de Cutis, Marco, Janigro, Damir, Runtz, Leonie, de Bock, Frederic, Barbier, Emmanuel L., Marchi, Nicola

“…•Differential impact of large and small caliber vessel on neuronal activity and parenchymal clearance mechanisms.•Mural cells and endothelial-pericyte…”
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Varying modalities of perinatal exposure to a pesticide cocktail elicit neurological adaptations in mice and zebrafish by Forner-Piquer, Isabel, Klement, Wendy, Gangarossa, Giuseppe, Zub, Emma, de Bock, Frederic, Blaquiere, Marine, Maurice, Tangui, Audinat, Etienne, Faucherre, Adèle, Lasserre, Frederic, Ellero-Simatos, Sandrine, Gamet-Payrastre, Laurence, Jopling, Chris, Marchi, Nicola

“…Epidemiological indications connect maternal and developmental presence or exposure to pesticides with an increased risk for a spectrum of neurological…”
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Epileptiform activity induces vascular remodeling and zonula occludens 1 downregulation in organotypic hippocampal cultures: role of VEGF signaling pathways by Morin-Brureau, Mélanie, Lebrun, Aurore, Rousset, Marie-Claude, Fagni, Laurent, Bockaert, Joël, de Bock, Frédéric, Lerner-Natoli, Mireille

“…Recent studies suggest that blood-brain barrier (BBB) permeability contributes to epileptogenesis in symptomatic epilepsies. We have previously described…”
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Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy by Rigau, Valérie, Morin, Mélanie, Rousset, Marie-Claude, de Bock, Frédéric, Lebrun, Aurore, Coubes, Philippe, Picot, Marie-Christine, Baldy-Moulinier, Michel, Bockaert, Joël, Crespel, Arielle, Lerner-Natoli, Mireille

“…Previous studies from our group, focusing on neuro-glial remodelling in human temporal lobe epilepsy (TLE), have shown the presence of immature vascular cells…”
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Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo by Boussadia, Baddreddine, Gangarossa, Giuseppe, Mselli-Lakhal, Laila, Rousset, Marie-Claude, de Bock, Frederic, Lassere, Frederic, Ghosh, Chaitali, Pascussi, Jean-Marc, Janigro, Damir, Marchi, Nicola

“…Nuclear receptors (NRs) are a group of transcription factors emerging as players in normal and pathological CNS development. Clinically, an association between…”
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