Search Results - "De Bleser, P."

Next-generation muscle-directed gene therapy by in silico vector design by Sarcar, S., Tulalamba, W., Rincon, M. Y., Tipanee, J., Pham, H. Q., Evens, H., Boon, D., Samara-Kuko, E., Keyaerts, M., Loperfido, M., Berardi, E., Jarmin, S., In’t Veld, P., Dickson, G., Lahoutte, T., Sampaolesi, M., De Bleser, P., VandenDriessche, T., Chuah, M. K.

“…There is an urgent need to develop the next-generation vectors for gene therapy of muscle disorders, given the relatively modest advances in clinical trials…”
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Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells by Tibbitt, Christopher Andrew, Stark, Julian Mario, Martens, Liesbet, Ma, Junjie, Mold, Jeff Eron, Deswarte, Kim, Oliynyk, Ganna, Feng, Xiaogang, Lambrecht, Bart Norbert, De Bleser, Pieter, Nylén, Susanne, Hammad, Hamida, Arsenian Henriksson, Marie, Saeys, Yvan, Coquet, Jonathan Marie

“…Naive CD4+ T cells differentiate into functionally diverse T helper (Th) cell subsets. Th2 cells play a pathogenic role in asthma, yet a clear picture of their…”
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Cell biology of liver endothelial and Kupffer cells by Smedsrød, B, De Bleser, P J, Braet, F, Lovisetti, P, Vanderkerken, K, Wisse, E, Geerts, A

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Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells by De Bleser, P J, Xu, G, Rombouts, K, Rogiers, V, Geerts, A

“…Reactive oxygen species are implicated in the pathogenesis of several diseases, including Alzheimer's disease, multiple sclerosis, human immunodeficiency…”
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Successful Targeting to Rat Hepatic Stellate Cells Using Albumin Modified with Cyclic Peptides That Recognize the Collagen Type VI Receptor by Beljaars, Leonie, Molema, Grietje, Schuppan, Detlef, Geerts, Albert, De Bleser, Pieter J., Weert, Betty, Meijer, Dirk K.F., Poelstra, Klaas

“…The key pathogenic event in liver fibrosis is the activation of hepatic stellate cells (HSC). Consequently, new antifibrotic therapies are directed toward an…”
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Insulin‐like growth factor II/mannose 6‐phosphate‐receptor expression in liver and serum during acute CCl4 intoxication in the rat by De Bleser, P J, Scott, C D, Niki, T, Xu, G, Wisse, E, Geerts, A

“…The liver is reported to be the main source of soluble insulin‐like growth factor‐II/mannose 6‐phosphate (IGF‐II/M6P) receptor in adults. In view of the role…”
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Transforming growth factor-β gene expression in normal and fibrotic rat liver by De Bleser, Pieter J., Niki, Toshiro, Rogiers, Vera, Geerts, Albert

“…Background/Aims: Transforming growth factor-β (TGF-β) is considered to be an important mediator in the development of fibrosis in several chronic liver…”
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Localization and cellular sources of activins in normal and fibrotic rat liver by De Bleser, P J, Niki, T, Xu, G, Rogiers, V, Geerts, A

“…Activins are dimeric proteins, members of the transforming growth factor β (TGF‐β) gene superfamily, consisting of the β‐subunits of inhibin (βA and βB)…”
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Liver-Specific Transcriptional Modules Identified by Genome-Wide In Silico Analysis Enable Efficient Gene Therapy in Mice and Non-Human Primates by Chuah, Marinee K, Petrus, Inge, De Bleser, Pieter, Le Guiner, Caroline, Gernoux, Gwladys, Adjali, Oumeya, Nair, Nisha, Willems, Jessica, Evens, Hanneke, Rincon, Melvin Y, Matrai, Janka, Di Matteo, Mario, Samara-Kuko, Ermira, Yan, Bing, Acosta-Sanchez, Abel, Meliani, Amine, Cherel, Ghislaine, Blouin, Véronique, Christophe, Olivier, Moullier, Philippe, Mingozzi, Federico, VandenDriessche, Thierry

“…The robustness and safety of liver-directed gene therapy can be substantially improved by enhancing expression of the therapeutic transgene in the liver. To…”
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Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4‐induced fibrotic rat livers by Niki, T, De Bleser, P J, Xu, G, Van der Berg, K, Wisse, E, Geerts, A

“…Fat‐storing cells are the major producers of extracellular matrix in the liver. A good immunocytochemical marker is, however, still lacking for this cell type…”
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ORegAnno: an open-access community-driven resource for regulatory annotation by Griffith, Obi L, Montgomery, Stephen B, Bernier, Bridget, Chu, Bryan, Kasaian, Katayoon, Aerts, Stein, Mahony, Shaun, Sleumer, Monica C, Bilenky, Mikhail, Haeussler, Maximilian, Griffith, Malachi, Gallo, Steven M, Giardine, Belinda, Hooghe, Bart, Van Loo, Peter, Blanco, Enrique, Ticoll, Amy, Lithwick, Stuart, Portales-Casamar, Elodie, Donaldson, Ian J, Robertson, Gordon, Wadelius, Claes, De Bleser, Pieter, Vlieghe, Dominique, Halfon, Marc S, Wasserman, Wyeth, Hardison, Ross, Bergman, Casey M, Jones, Steven J.M

“…ORegAnno is an open-source, open-access database and literature curation system for community-based annotation of experimentally identified DNA regulatory…”
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Insufficient TGF-beta 1 production inactivates the autocrine growth suppressive circuit in human ovarian cancer cell lines by Zeinoun, Z, Teugels, E, De Bleser, P J, Neyns, B, Geerts, A, De Greve, J

“…TGF-beta 1 is a secreted polypeptide that elicits an antiproliferanve response in many cell types. However, many epithelial cancer cell lines are resistant to…”
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Insulin-like growth factor II/mannose 6-phosphate-receptor expression in liver and serum during acute CCl4 intoxication in the rat by De Bleser, PJ, Scott, CD, Niki, T, Xu, G, Wisse, E, Geerts, A

“…The liver is reported to be the main source of soluble insulin-like growth factor-II/mannose 6-phosphate (IGF-II/M6P) receptor in adults. In view of the role…”
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Localization and cellular sources of activins in normal and fibrotic rat liver by De Bleser, PJ, Niki, T, Xu, G, Rogiers, V, Geerts, A

“…Activins are dimeric proteins, members of the transforming growth factor beta (TGF-beta) gene superfamily, consisting of the beta-subunits of inhibin (betaA…”
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Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat‐storing cells by Niki, T, Schuppan, D, de Bleser, P J, Vrijsen, R, Pipeleers‐Marichal, M, Beyaert, R, Wisse, E, Geerts, A

“…Glucocorticoids have been shown to suppress collagen synthesis and gene expression by fibroblasts. However, little is known about their effects on fat‐storing…”
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Human metallothionein expression under normal and pathological conditions: mechanisms of gene regulation based on in silico promoter analysis by Laukens, Debby, Waeytens, Anouk, De Bleser, Pieter, Cuvelier, Claude, De Vos, Martine

“…Metallothioneins (MTs) are ubiquitous metal-binding proteins that have been highly conserved throughout evolution. Although their physiological function is not…”
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Role of fat-storing cells in hepatic fibrogenesis. Retinoids as possible therapeutic agents by De Bleser, P, Geerts, A, Wisse, E

“…In normal liver, fat-storing cells are the main storage site of vitamin A derivatives, mainly of retinyl palmitate and oleate. During liver injury, the…”
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Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts by Rombouts, Krista, Niki, Toshiro, Greenwel, Patricia, Vandermonde, Alain, Wielant, Annemie, Hellemans, Karine, De Bleser, Pieter, Yoshida, Minoru, Schuppan, Detlef, Rojkind, Marcos, Geerts, Albert

“…Excessive production of collagens by alpha-smooth muscle actin (alpha-SMA)-positive myofibroblasts leads to fibrotic skin diseases, such as hypertrophic…”
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A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture by Niki, Toshiro, Rombouts, Krista, De Bleser, Pieter, De Smet, Karen, Rogiers, Vera, Schuppan, Detlef, Yoshida, Minoru, Gabbiani, Giulio, Geerts, Albert

“…Hepatic stellate cells are the major cellular sources of extracellular matrix in chronic liver diseases leading to fibrosis. We explored the antifibrogenic…”
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Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor by Rombouts, Krista, Knittel, Thomas, Machesky, Laura, Braet, Filip, Wielant, Annemie, Hellemans, Karine, De Bleser, Pieter, Gelman, Irwin, Ramadori, Giuliano, Geerts, Albert

“…Background/Aims: Previously, trichostatin A (TSA), a histone deacetylase inhibitor, has been shown to exhibit strong antifibrotic characteristics in hepatic…”
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