Role of Viral Molecular Panels in Diagnosing the Etiology of Fever in Infants Younger Than 3 Months

Role of Viral Molecular Panels in Diagnosing the Etiology of Fever in Infants Younger Than 3 Months

As infants with proven viral infection present lower risk of bacterial infection, we evaluated how molecular methods detecting viruses on respiratory secretions could contribute to etiological diagnostic of these febrile episodes. From November 2010 to May 2011, we enrolled all febrile infants <9...

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Bibliographic Details
Published in:Clinical pediatrics Vol. 59; no. 1; pp. 45 - 52
Main Authors: Epalza, Cristina, Hallin, Marie, Busson, Laurent, Debulpaep, Sara, De Backer, Paulette, Vandenberg, Olivier, Levy, Jack
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-01-2020
Westminster Publications, Inc
Subjects:
Bacterial infections
Emergency medical care
Emergency medical services
Etiology
Fever
Health risks
Infants
Infections
Medical diagnosis
Secretions
Viral infections
Viruses
respiratory virus
fever under 3 months
etiology
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Summary:As infants with proven viral infection present lower risk of bacterial infection, we evaluated how molecular methods detecting viruses on respiratory secretions could contribute to etiological diagnostic of these febrile episodes. From November 2010 to May 2011, we enrolled all febrile infants <90 days presenting to emergency room. Standard workup included viral rapid antigenic test and viral culture on nasopharyngeal aspirate. Samples negative by rapid testing were tested by molecular methods. From 208 febrile episodes (198 infants) with standard techniques, rate of documented microbiological etiology was 13% at emergency department, 47% during hospitalization, and 64% with viral cultures. Molecular methods increased microbiologically documented etiology rate by 12%, to 76%. Contribution of molecular methods was the highest in infants without clinical source of infection, increasing documentation by 18%, from 50% to 68%. Making viral molecular results rapidly available could help identifying a higher proportion of infants at low risk of serious bacterial infection.
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ISSN:0009-9228
1938-2707
DOI:10.1177/0009922819884582