Circulating and peritoneal fluid interleukin-6 levels and gene expression in pelvic endometriosis

Current data are inconsistent regarding the association between interleukin-6 (IL-6), a marker of acute phase inflammation, and pelvic endometriosis. The aim of the present study was to assess IL-6 levels in serum and peritoneal fluid (PF), as well as IL-6 gene expression in adipose tissue (AT) and...

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Bibliographic Details
Published in:	Experimental and therapeutic medicine Vol. 14; no. 3; pp. 2317 - 2322
Main Authors:	De Andrade, Vânia Teixeira, Nácul, Andréa Prestes, Dos Santos, Betânia Rodrigues, Lecke, Sheila Bünecker, Spritzer, Poli Mara, Morsch, Débora Martinho
Format:	Journal Article
Language:	English
Published:	Greece D.A. Spandidos 01-09-2017 Spandidos Publications Spandidos Publications UK Ltd
Subjects:	adipose tissue Analysis Cytokines Endometriosis Gene expression Genetic aspects Gynecology Interleukin-6 Laparoscopy Menstruation Pathogenesis Patients peritoneal fluid Protein expression Studies Womens health adipose tissue endometriosis peritoneal fluid gene expression interleukin-6
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Summary:	Current data are inconsistent regarding the association between interleukin-6 (IL-6), a marker of acute phase inflammation, and pelvic endometriosis. The aim of the present study was to assess IL-6 levels in serum and peritoneal fluid (PF), as well as IL-6 gene expression in adipose tissue (AT) and endometrial samples in pelvic endometriosis. A total of 30 patients with endometriosis and 18 women with a normal pelvis were enrolled in this case-control study. IL-6 levels in PF and serum were determined using a human enzyme-linked immunosorbent assay and IL-6 gene expression was evaluated using reverse transcription-quantitative polymerase chain reaction. It was observed that IL-6 levels in the PF were higher in patients with endometriosis than in the control group (P=0.047) and patients with stage III/IV endometriosis exhibited higher IL-6 levels in the PF than those with stage I/II endometriosis and the control group (P<0.001). Furthermore, a strong correlation between PF IL-6 levels and the revised American Society for Reproductive Medicine score for endometriosis severity was identified (r=0.77; P<0.001). IL-6 gene expression did not differ significantly between endometriosis and control groups in endometrial samples or in AT of both groups. The results of the current study suggest that there may be an association between IL-6 and the presence and severity of pelvic endometriosis. The source of this higher IL-6 seems not to be specifically related to regional AT.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributed equally
ISSN:	1792-0981 1792-1015
DOI:	10.3892/etm.2017.4794