Search Results - "De Aguero, Mercedes Gomez"
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Neuronal programming by microbiota regulates intestinal physiology
Published in Nature (London) (13-02-2020)“…Neural control of the function of visceral organs is essential for homeostasis and health. Intestinal peristalsis is critical for digestive physiology and host…”
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2
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Published in eLife (13-04-2021)“…Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer's disease (AD) progression. However, the mechanisms of…”
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3
Resident macrophages acquire innate immune memory in staphylococcal skin infection
Published in eLife (08-07-2020)“…is a common colonizer of healthy skin and mucous membranes. At the same time, is the most frequent cause of skin and soft tissue infections. Dermal macrophages…”
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Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation
Published in Nature communications (14-04-2020)“…Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in the spleen, they fail to induce CD4 + T cell proliferation in the…”
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Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity
Published in Nature communications (24-04-2020)“…There is the notion that infection with a virulent intestinal pathogen induces generally stronger mucosal adaptive immunity than the exposure to an avirulent…”
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Author Correction: Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity
Published in Nature communications (29-01-2021)“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21096-5…”
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7
The maternal microbiota drives early postnatal innate immune development
Published in Science (American Association for the Advancement of Science) (18-03-2016)“…Postnatal colonization of the body with microbes is assumed to be the main stimulus to postnatal immune development. By transiently colonizing pregnant female…”
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Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements
Published in Cell metabolism (04-12-2018)“…Caloric restriction (CR) stimulates development of functional beige fat and extends healthy lifespan. Here we show that compositional and functional changes in…”
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Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response
Published in Immunity (Cambridge, Mass.) (18-09-2018)“…Although the mammalian microbiota is well contained within the intestine, it profoundly shapes development and metabolism of almost every host organ. We…”
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Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues
Published in Nature immunology (01-10-2021)“…Innate lymphoid cells (ILCs) participate in tissue homeostasis, inflammation, and early immunity against infection. It is unclear how ILCs acquire effector…”
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P2X1‐regulated IL‐22 secretion by innate lymphoid cells is required for efficient liver regeneration
Published in Hepatology (Baltimore, Md.) (01-06-2016)“…Paracrine signalling mediated by cytokine secretion is essential for liver regeneration after hepatic resection, yet the mechanisms of cellular crosstalk…”
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12
The immunological functions of the Appendix: An example of redundancy?
Published in Seminars in immunology (01-04-2018)“…•The Appendix appeared several independent times and is conserved in evolution.•The Appendix is rich in lymphoid tissue and contributes to intestinal…”
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Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling
Published in Nature communications (16-12-2021)“…Abdominal surgeries are lifesaving procedures but can be complicated by the formation of peritoneal adhesions, intra-abdominal scars that cause intestinal…”
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MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice
Published in Gastroenterology (New York, N.Y. 1943) (01-07-2020)“…Intestinal epithelial homeostasis depends on a tightly regulated balance between intestinal epithelial cell (IEC) death and proliferation. While the disruption…”
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Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease
Published in Acta neuropathologica communications (29-07-2020)“…Abstract It was recently revealed that gut microbiota promote amyloid-beta (Aβ) burden in mouse models of Alzheimer’s disease (AD). However, the underlying…”
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NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death
Published in The Journal of immunology (1950) (15-07-2019)“…The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role…”
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Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response
Published in PLoS pathogens (01-04-2022)“…Interactions between pathogens, host microbiota and the immune system influence many physiological and pathological processes. In the 20th century, widespread…”
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Intestinal dendritic cell licensing through Toll-like receptor 4 is required for oral tolerance in allergic contact dermatitis
Published in Journal of allergy and clinical immunology (01-01-2018)“…Induction of oral tolerance to haptens is an efficient way to prevent allergic contact dermatitis (ACD) in mice. Toll-like receptor (TLR)–mediated sensing of…”
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S1PR5 is pivotal for the homeostasis of patrolling monocytes
Published in European journal of immunology (01-06-2013)“…Patrolling Ly6C− monocytes are blood‐circulating cells that play a role in inflammation and in the defense against pathogens. Here, we show that similar to…”
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The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia
Published in iScience (22-10-2021)“…The gut microbiome has been implicated as a key regulator of brain function in health and disease. But the impact of gut microbiota on functional brain…”
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