Search Results - "De Abreu, R A"

Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells by Wielinga, P R, Reid, G, Challa, E E, van der Heijden, I, van Deemter, L, de Haas, M, Mol, C, Kuil, A J, Groeneveld, E, Schuetz, J D, Brouwer, C, De Abreu, R A, Wijnholds, J, Beijnen, J H, Borst, P

“…Mercaptopurines have been used as anticancer agents for more than 40 years, and most acute lymphoblastic leukemias are treated with 6-mercaptopurine (6MP) or…”
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Blunted GABA-mediated inhibition within the dorsomedial hypothalamus potentiates the cardiovascular response to emotional stress in rats fed a high-fat diet by Abreu, A.R, de Abreu, A.R, Santos, L.T, de Souza, A.A, da Silva, L.G, Chianca, D.A, de Menezes, R.C

“…Highlights • The cardiovascular reactivity to emotional stress is increased in obese rats. • Obesity impairs the reduction in the stress response caused by…”
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Genetic polymorphism of thiopurine S-methyltransferase in Argentina by Laróvere, L E, de Kremer, R Dodelson, Lambooy, L H J, De Abreu, R A

“…Thiopurine methyltransferase (TPMT) catalyses the S-methylation of 6-thiopurine drugs, which are commonly used in the treatment of autoimmune diseases,…”
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Methotrexate in rheumatoid arthritis : An update with focus on mechanisms involved in toxicity by VAN EDE, A. E, LAAN, R. F. J. M, BLOM, H. J, DE ABREU, R. A, VAN DE PUTTE, L. B. A

“…To provide an update of the current knowledge of the mechanism of action of low-dose methotrexate (MTX) in the treatment of patients with rheumatoid arthritis…”
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Local and regional albedo observations of arctic first-year sea ice during melt ponding by Hanesiak, J. M., Barber, D. G., De Abreu, R. A., Yackel, J. J.

“…The shortwave surface albedo is a critical climatological parameter for sea ice, especially during the spring melt period when the ice contains a mixture of…”
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Amygdalar neuronal activity mediates the cardiovascular responses evoked from the dorsolateral periaqueductal gray in conscious rats by de Abreu, A.R, Abreu, A.R, Santos, L.T, de Souza, A.A, da Silva, L.G, Chianca, D.A, de Menezes, R.C

“…Highlights • Responses elicited by dlPAG activation require the neuronal activity in the BLA. • Responses caused by the dlPAG activation depend on…”
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Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity by Van Kuilenburg, A.B.P., Vreken, P., Beex, L.V.A.M., Meinsma, R., Van Lenthe, H., De Abreu, R.A., Van Gennip, A.H.

“…Dihydropyrimidine dehydrogenase (DPD) is responsible for the breakdown of the widely used antineoplastic agent 5-fluorouracil (5-FU), thereby limiting the…”
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Purine enzymes in patients with rheumatoid arthritis treated with methotrexate by van Ede, A E, Laan, R F J M, De Abreu, R A, Stegeman, A B J, van de Putte, L B A

“…Objectives: To study (a) purine metabolism during treatment with methotrexate (MTX) in patients with rheumatoid arthritis (RA) and (b) the relation of purine…”
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Strategies for surgically assisted rapid maxillary expansion according to the region of transverse maxillary deficiency by Pereira, M.D, de Abreu, R.A.M, Prado, G.P.R, Ferreira, L.M

“…Abstract This study evaluated different techniques for surgically assisted rapid maxillary expansion (SARME) according to the type of transverse maxillary…”
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Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene by Brouwer, C, Marinaki, A M, Lambooy, L H, Duley, J A, Shobowale-Bakre, M, De Abreu, R A

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Abdominal TRPV1 channel desensitization enhances stress-induced hyperthermia during social stress in rats by Reis, T.O., Noronha, S.I.S.R., Lima, P.M.A., De Abreu, A.R.R., Mesquita, L.B.T., Ferreira, F.I., Silva, F.C., Chianca-Jr, D.A., De Menezes, R.C.

“…In rats, stress-induced hyperthermia caused by social interaction depends on brown adipose tissue (BAT) thermogenesis and peripheral vasoconstriction. However,…”
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DNA methylation patterns in the calcitonin gene region at first diagnosis and at relapse of acute lymphoblastic leukemia (ALL) by LEEGWATER, P. A. J, LAMBOOY, L. H. J, DE ABREU, R. A, BÖKKERINK, J. P. M, VAN DEN HEUVEL, L

“…Aberrant DNA methylation can occur early in neoplastic transformation and may lead to the development of cancer. We describe the alterations of methylation…”
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Polyamines and DNA methylation in childhood leukaemia by Schipper, R G, van den Heuvel, L P, Verhofstad, A A J, De Abreu, R A

“…Both polyamine metabolism and DNA methylation play an important role in normal and malignant growth. Specific enzyme inhibitors or drugs that interfere with…”
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Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency by VAN KUILENBURG, A. B. P, VREKEN, P, CHRISTENSEN, E, HOLOPAINEN, I, PULKKI, K, RIVA, D, BOTTEON, G, HOLME, E, TULINIUS, M, KLEIJER, W. J, BEEMER, F. A, DURAN, M, ABELING, N. G. G. M, NIEZEN-KONING, K. E, SMIT, G. P. A, JAKOBS, C, SMIT, L. M. E, MOOG, U, SPAAPEN, L. J. M, VAN GENNIP, A. H, BAKKER, H. D, MEINSMA, R, VAN LENTHE, H, DE ABREU, R. A, SMEITINK, J. A. M, KAYSERILI, H, APAK, M. Y

“…Dihydropyrimidine dehydrogenase (DPD) deficiency is an autosomal recessive disease characterised by thymine-uraciluria in homozygous deficient patients and has…”
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Identification of a four-base deletion (deITCAT296-299) in the dihydropyrimidine dehydrogenase gene with variable clinical expression by VREKEN, P, VAN KUILENBURG, A. B. P, MEINSMA, R, DE ABREU, R. A, VAN GENNIP, A. H

“…Dihydropyrimidine dehydrogenase catalyzes the first and rate-limiting step in the breakdown of thymine, uracil, and the widely used antineoplastic drug,…”
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Analysis of DNA methylation of the 5′ region of the deoxycytidine kinase gene in CCRF-CEM-sensitive and cladribine (CdA)- and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine (CAFdA)-resistant cells by Leegwater, P.A.J, De Abreu, R.A, Albertioni, F

“…DNA methylation of the CpG-rich 5′ region of the deoxycytidine kinase (dCK) gene is potentially involved in the suppression of the gene and the resistance of…”
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Effect of Rhenium on the Catalytic Activity of Activated Carbon-Supported Nickel Applied in the Hydrogenation of Furfural and Levulinic Acid by de Abreu, Claudio R. A., Simon, Pardis, Wojcieszak, Robert, de Souza, Priscilla M., Toniolo, Fabio S.

“…This work evaluates the performance of activated carbon-supported Ni and Re catalysts in the hydrogenation of furfural and levulinic acid. The increase in Re…”
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Development of methionine synthase, cystathionine-β-synthase and S-adenosyl-homocysteine hydrolase during gestation in rats by VanAerts, L A, Poirot, C M, Herberts, C A, Blom, H J, De Abreu, R A, Trijbels, J M, Eskes, T K, Peereboom-Stegeman, J H, Noordhoek, J

“…The developmental onset of three homocysteine metabolizing enzymes in the rat conceptus was investigated. Cystathionine-β-synthase and methionine synthase were…”
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Severe 5‐fluorouracil toxicity caused by reduced dihydropyrimidine dehydrogenase activity due to heterozygosity for a G→A point mutation by Kuilenburg, A. B. P., Vreken, P., Beex, L. V. A. M., De Abreu, R. A., Gennip, A. H.

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Clinical Implications of Dihydropyrimidine Dehydrogenase (DPD) Deficiency in Patients with Severe 5-Fluorouracil-associated Toxicity: Identification of New Mutations in the DPD Gene by VAN KUILENBURG, André B. P, HAASJES, Janet, RICHEL, Dick J, ZOETEKOUW, Lida, VAN LENTHE, Henk, DE ABREU, Ronney A, MARING, Jan G, VREKEN, Peter, VAN GENNIP, Albert H

“…Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU), and it is suggested that patients with…”
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