Search Results - "De Palma, Michele"

Macrophage Regulation of Tumor Responses to Anticancer Therapies by De Palma, Michele, Lewis, Claire E.

“…Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like angiogenesis, immunosuppression, invasion, and metastasis. Increasing…”
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Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles by Jahani, Yasaman, Arvelo, Eduardo R., Yesilkoy, Filiz, Koshelev, Kirill, Cianciaruso, Chiara, De Palma, Michele, Kivshar, Yuri, Altug, Hatice

“…Biosensors are indispensable tools for public, global, and personalized healthcare as they provide tests that can be used from early disease detection and…”
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Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells by Mazzieri, Roberta, Pucci, Ferdinando, Moi, Davide, Zonari, Erika, Ranghetti, Anna, Berti, Alvise, Politi, Letterio S., Gentner, Bernhard, Brown, Jeffrey L., Naldini, Luigi, De Palma, Michele

“…Tumor-infiltrating myeloid cells convey proangiogenic programs that counteract the efficacy of antiangiogenic therapy. Here, we show that blocking…”
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Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity by Hoves, Sabine, Ooi, Chia-Huey, Wolter, Carsten, Sade, Hadassah, Bissinger, Stefan, Schmittnaegel, Martina, Ast, Oliver, Giusti, Anna M, Wartha, Katharina, Runza, Valeria, Xu, Wei, Kienast, Yvonne, Cannarile, Michael A, Levitsky, Hyam, Romagnoli, Solange, De Palma, Michele, Rüttinger, Dominik, Ries, Carola H

“…Depletion of immunosuppressive tumor-associated macrophages (TAMs) or reprogramming toward a proinflammatory activation state represent different strategies to…”
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Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade by Rigamonti, Nicolò, Kadioglu, Ece, Keklikoglou, Ioanna, Wyser Rmili, Céline, Leow, Ching Ching, De Palma, Michele

“…Angiopoietin-2 (ANG2/ANGPT2) is a context-dependent TIE2 receptor agonist/antagonist and proangiogenic factor. Although ANG2 neutralization improves tumor…”
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Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2 by Keskin, Doruk, Kim, Jiha, Cooke, Vesselina G., Wu, Chia-Chin, Sugimoto, Hikaru, Gu, Chenghua, De Palma, Michele, Kalluri, Raghu, LeBleu, Valerie S.

“…Strategies to target angiogenesis include inhibition of the vessel-stabilizing properties of vascular pericytes. Pericyte depletion in early-stage non-hypoxic…”
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Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord by Cusimano, Melania, Biziato, Daniela, Brambilla, Elena, Donegà, Matteo, Alfaro-Cervello, Clara, Snider, Silvia, Salani, Giuliana, Pucci, Ferdinando, Comi, Giancarlo, Garcia-Verdugo, Jose Manuel, De Palma, Michele, Martino, Gianvito, Pluchino, Stefano

“…Transplanted neural stem/precursor cells possess peculiar therapeutic plasticity and can simultaneously instruct several therapeutic mechanisms in addition to…”
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Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer by Venneri, Mary Anna, Palma, Michele De, Ponzoni, Maurilio, Pucci, Ferdinando, Scielzo, Cristina, Zonari, Erika, Mazzieri, Roberta, Doglioni, Claudio, Naldini, Luigi

“…Tumor-infiltrating myeloid cells, including tumor-associated macrophages (TAMs), have been implicated in tumor progression. We recently described a lineage of…”
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miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages by Squadrito, Mario Leonardo, Pucci, Ferdinando, Magri, Laura, Moi, Davide, Gilfillan, Gregor D., Ranghetti, Anna, Casazza, Andrea, Mazzone, Massimiliano, Lyle, Robert, Naldini, Luigi, De Palma, Michele

“…Expression of the mannose receptor (MRC1/CD206) identifies macrophage subtypes, such as alternatively activated macrophages (AAMs) and M2-polarized…”
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Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression by Galletti, Giovanni, Scielzo, Cristina, Barbaglio, Federica, Rodriguez, Tania Véliz, Riba, Michela, Lazarevic, Dejan, Cittaro, Davide, Simonetti, Giorgia, Ranghetti, Pamela, Scarfò, Lydia, Ponzoni, Maurilio, Rocchi, Martina, Corti, Angelo, Anselmo, Achille, van Rooijen, Nico, Klein, Christian, Ries, Carola H., Ghia, Paolo, De Palma, Michele, Caligaris-Cappio, Federico, Bertilaccio, Maria Teresa Sabrina

“…The role of monocytes/macrophages in the development and progression of chronic lymphocytic leukemia (CLL) is poorly understood. Transcriptomic analyses show…”
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Engineering dendritic cell vaccines to improve cancer immunotherapy by Perez, Caleb R., De Palma, Michele

“…At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized…”
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Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells by Squadrito, Mario Leonardo, Baer, Caroline, Burdet, Frédéric, Maderna, Claudio, Gilfillan, Gregor D., Lyle, Robert, Ibberson, Mark, De Palma, Michele

“…MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication. Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent…”
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A Role for Angiopoietin-2 in Organ-Specific Metastasis by Rigamonti, Nicolò, De Palma, Michele

“…Angiopoietin-2 (ANG2/ANGPT2) has recently emerged as a promising target for the inhibition of tumor metastasis. In this issue of Cell Reports, Minami et al…”
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The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner by Luck, Robert, Karakatsani, Andromachi, Shah, Bhavin, Schermann, Geza, Adler, Heike, Kupke, Janina, Tisch, Nathalie, Jeong, Hyun-Woo, Back, Michaela Kerstin, Hetsch, Florian, D’Errico, Anna, De Palma, Michele, Wiedtke, Ellen, Grimm, Dirk, Acker-Palmer, Amparo, von Engelhardt, Jakob, Adams, Ralf H., Augustin, Hellmut G., Ruiz de Almodóvar, Carmen

“…Neuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling…”
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Perivascular macrophages in health and disease by Lapenna, Antonio, De Palma, Michele, Lewis, Claire E.

“…Macrophages are a heterogeneous group of cells that are capable of carrying out distinct functions in different tissues, as well as in different locations…”
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Boosting dendritic cell nanovaccines by Mohammadzadeh, Yahya, De Palma, Michele

“…A preclinical study reports a platform for the generation of dendritic cell-derived nanovesicles with enhanced immunostimulatory function, which demonstrate…”
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The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors by Harney, Allison S., Karagiannis, George S., Pignatelli, Jeanine, Smith, Bryan D., Kadioglu, Ece, Wise, Scott C., Hood, Molly M., Kaufman, Michael D., Leary, Cynthia B., Lu, Wei-Ping, Al-Ani, Gada, Chen, Xiaoming, Entenberg, David, Oktay, Maja H., Wang, Yarong, Chun, Lawrence, De Palma, Michele, Jones, Joan G., Flynn, Daniel L., Condeelis, John S.

“…Abstract Tumor-infiltrating myeloid cells promote tumor progression by mediating angiogenesis, tumor cell intravasation, and metastasis, which can offset the…”
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The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilities by De Palma, Michele, Hanahan, Douglas

“…It is a time of great promise and expectation for the applications of knowledge about mechanisms of cancer toward more effective and enduring therapies for…”
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Dendritic cell cross‐dressing and tumor immunity by Martinez‐Usatorre, Amaia, De Palma, Michele

“…In addition to direct and cross‐presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly understood mechanism…”
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Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models by Keklikoglou, Ioanna, Cianciaruso, Chiara, Güç, Esra, Squadrito, Mario Leonardo, Spring, Laura M., Tazzyman, Simon, Lambein, Lore, Poissonnier, Amanda, Ferraro, Gino B., Baer, Caroline, Cassará, Antonino, Guichard, Alan, Iruela-Arispe, M. Luisa, Lewis, Claire E., Coussens, Lisa M., Bardia, Aditya, Jain, Rakesh K., Pollard, Jeffrey W., De Palma, Michele

“…Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has…”
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