Search Results - "De Koninck, Yves"

A Simplified Up-Down Method (SUDO) for Measuring Mechanical Nociception in Rodents Using von Frey Filaments by Bonin, Robert P, Bories, Cyril, De Koninck, Yves

“…Background: The measurement of mechanosensitivity is a key method for the study of pain in animal models. This is often accomplished with the use of von Frey…”
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Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization by Ferrini, Francesco, Perez-Sanchez, Jimena, Ferland, Samuel, Lorenzo, Louis-Etienne, Godin, Antoine G., Plasencia-Fernandez, Isabel, Cottet, Martin, Castonguay, Annie, Wang, Feng, Salio, Chiara, Doyon, Nicolas, Merighi, Adalberto, De Koninck, Yves

“…GABA A /glycine-mediated neuronal inhibition critically depends on intracellular chloride (Cl − ) concentration which is mainly regulated by the K + -Cl −…”
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Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain by Lorenzo, Louis-Etienne, Godin, Antoine G., Ferrini, Francesco, Bachand, Karine, Plasencia-Fernandez, Isabel, Labrecque, Simon, Girard, Alexandre A., Boudreau, Dominic, Kianicka, Irenej, Gagnon, Martin, Doyon, Nicolas, Ribeiro-da-Silva, Alfredo, De Koninck, Yves

“…Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported,…”
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The International Brain Initiative: enabling collaborative science by Quaglio, Gianluca, Toia, Patrizia, Moser, Edvard I, Karapiperis, Theodoros, Amunts, Katrin, Okabe, Shigeo, Poo, Mu-ming, Rah, Jong-Cheol, Koninck, Yves De, Ngai, John, Richards, Linda, Bjaalie, Jan G

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Amiloride modulation of carbon dioxide hypersensitivity and thermal nociceptive hypersensitivity induced by interference with early maternal environment by Battaglia, Marco, Rossignol, Orlane, Bachand, Karine, D’Amato, Francesca R, Koninck, Yves De

“…Background: Early life adversities are risk factors for anxiety disorders and for pain syndromes, which are, in turn, highly comorbid with anxiety disorders…”
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Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain by Koninck, Yves De, Coull, Jeffrey A. M, Boudreau, Dominic, Bachand, Karine, Prescott, Steven A, Nault, Francine, Sík, Attila, Koninck, Paul De

“…Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn of the spinal cord is a crucial substrate for chronic pain…”
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Transformation of the Output of Spinal Lamina I Neurons After Nerve Injury and Microglia Stimulation Underlying Neuropathic Pain by Keller, A Florence, Beggs, Simon, Salter, Michael W, De Koninck, Yves

“…Background: Disinhibition of neurons in the superficial spinal dorsal horn, via microglia – neuron signaling leading to disruption of chloride homeostasis, is…”
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Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition by Mahadevan, Vivek, Khademullah, C Sahara, Dargaei, Zahra, Chevrier, Jonah, Uvarov, Pavel, Kwan, Julian, Bagshaw, Richard D, Pawson, Tony, Emili, Andrew, De Koninck, Yves, Anggono, Victor, Airaksinen, Matti, Woodin, Melanie A

“…KCC2 is a neuron-specific K -Cl cotransporter essential for establishing the Cl gradient required for hyperpolarizing inhibition in the central nervous system…”
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Spatial and Temporal Pattern of Changes in the Number of GAD65-Immunoreactive Inhibitory Terminals in the Rat Superficial Dorsal Horn following Peripheral Nerve Injury by Lorenzo, Louis-Etienne, Magnussen, Claire, Bailey, Andrea L, St Louis, Manon, De Koninck, Yves, Ribeiro-da-Silva, Alfredo

“…Inhibitory interneurons are an important component of dorsal horn circuitry where they serve to modulate spinal nociception. There is now considerable evidence…”
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A Wireless Optogenetic Headstage with Multichannel Electrophysiological Recording Capability by Gagnon-Turcotte, Gabriel, Kisomi, Alireza Avakh, Ameli, Reza, Camaro, Charles-Olivier Dufresne, LeChasseur, Yoan, Néron, Jean-Luc, Bareil, Paul Brule, Fortier, Paul, Bories, Cyril, de Koninck, Yves, Gosselin, Benoit

“…We present a small and lightweight fully wireless optogenetic headstage capable of optical neural stimulation and electrophysiological recording. The headstage…”
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Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia by Price, Theodore J, Cervero, Fernando, de Koninck, Yves

“…The importance of the GABAergic system in spinal nociceptive processing has long been appreciated but we have only recently begun to understand how this system…”
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Microglia Control Neuronal Network Excitability via BDNF Signalling by Ferrini, Francesco, De Koninck, Yves

“…Microglia-neuron interactions play a crucial role in several neurological disorders characterized by altered neural network excitability, such as epilepsy and…”
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Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat by Prescott, Steven A., Koninck, Yves De

“…Lamina I of the spinal dorsal horn plays an important role in the processing and relay of nociceptive information. Signal processing depends, in part, on…”
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Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition by Doyon, Nicolas, Vinay, Laurent, Prescott, Steven A., De Koninck, Yves

“…Fast synaptic inhibition relies on tight regulation of intracellular Cl−. Chloride dysregulation is implicated in several neurological and psychiatric…”
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Differential Maturation of GABA Action and Anion Reversal Potential in Spinal Lamina I Neurons: Impact of Chloride Extrusion Capacity by Cordero-Erausquin, Matilde, Coull, Jeffrey A. M, Boudreau, Dominic, Rolland, Matthias, Koninck, Yves De

“…A deficit in inhibition in the spinal dorsal horn has been proposed to be an underlying cause of the exaggerated cutaneous sensory reflexes observed in newborn…”
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Reduction of Anion Reversal Potential Subverts the Inhibitory Control of Firing Rate in Spinal Lamina I Neurons: Towards a Biophysical Basis for Neuropathic pain by Prescott, Steven A, Sejnowski, Terrence J, De Koninck, Yves

“…Background Reduction of the transmembrane chloride gradient in spinal lamina I neurons contributes to the cellular hyperexcitability producing allodynia and…”
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Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells by Miraucourt, Loïs S, Tsui, Jennifer, Gobert, Delphine, Desjardins, Jean-François, Schohl, Anne, Sild, Mari, Spratt, Perry, Castonguay, Annie, De Koninck, Yves, Marsh-Armstrong, Nicholas, Wiseman, Paul W, Ruthazer, Edward S

“…Type 1 cannabinoid receptors (CB1Rs) are widely expressed in the vertebrate retina, but the role of endocannabinoids in vision is not fully understood. Here,…”
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Normal and abnormal coding of somatosensory stimuli causing pain by Prescott, Steven A, Ma, Qiufu, De Koninck, Yves

“…There is growing evidence for the existence of cross-talk between somatosensory labeled lines during the processing of noxious information, lending support to…”
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Extended depth of field microscopy for rapid volumetric two-photon imaging by Thériault, Gabrielle, De Koninck, Yves, McCarthy, Nathalie

“…Two-photon fluorescence microscopy is an influential tool in biology, providing valuable information on the activity of cells deep inside the tissue. However,…”
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A novel assessment of fine-motor function reveals early hindlimb and detectable forelimb deficits in an experimental model of ALS by Khademullah, C. Sahara, De Koninck, Yves

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with the loss of cortical and spinal motor neurons (MNs) and muscle degeneration…”
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