Search Results - "De Jonghe, Bart C."

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation by Hayes, Matthew R., Leichner, Theresa M., Zhao, Shiru, Lee, Grace S., Chowansky, Amy, Zimmer, Derek, De Jonghe, Bart C., Kanoski, Scott E., Grill, Harvey J., Bence, Kendra K.

“…Glucagon-like peptide-1 receptor (GLP-1R) activation within the nucleus tractus solitarius (NTS) suppresses food intake and body weight (BW), but the…”
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Chemotherapy-induced pica and anorexia are reduced by common hepatic branch vagotomy in the rat by De Jonghe, Bart C, Horn, Charles C

“…Anticancer agents, such as cisplatin, induce vomiting, nausea, and anorexia. Cisplatin primarily acts on vagal afferents to produce emesis, but little is known…”
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A Neural Circuit for the Suppression of Pain by a Competing Need State by Alhadeff, Amber L., Su, Zhenwei, Hernandez, Elen, Klima, Michelle L., Phillips, Sophie Z., Holland, Ruby A., Guo, Caiying, Hantman, Adam W., De Jonghe, Bart C., Betley, J. Nicholas

“…Hunger and pain are two competing signals that individuals must resolve to ensure survival. However, the neural processes that prioritize conflicting survival…”
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Central mechanisms of emesis: A role for GDF15 by Borner, Tito, Pataro, Allison M, De Jonghe, Bart C

“…Nausea and emesis are ubiquitously reported medical conditions and often present as treatment side effects along with polymorbidities contributing to…”
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GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models by Borner, Tito, Geisler, Caroline E, Fortin, Samantha M, Cosgrove, Richard, Alsina-Fernandez, Jorge, Dogra, Mridula, Doebley, Sarah, Sanchez-Navarro, Marcos J, Leon, Rosa M, Gaisinsky, Jane, White, Arianna, Bamezai, Ankur, Ghidewon, Misgana Y, Grill, Harvey J, Crist, Richard C, Reiner, Benjamin C, Ai, Minrong, Samms, Ricardo J, De Jonghe, Bart C, Hayes, Matthew R

“…Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity and diabetes. Patient compliance and maximal…”
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Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation by Hayes, Matthew R., Leichner, Theresa M., Zhao, Shiru, Lee, Grace S., Chowansky, Amy, Zimmer, Derek, De Jonghe, Bart C., Kanoski, Scott E., Grill, Harvey J., Bence, Kendra K.

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GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss by Borner, Tito, Wald, Hallie S., Ghidewon, Misgana Y., Zhang, Bei, Wu, Zhidan, De Jonghe, Bart C., Breen, Danna, Grill, Harvey J.

“…The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current…”
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The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide by Kanoski, Scott E., Rupprecht, Laura E., Fortin, Samantha M., De Jonghe, Bart C., Hayes, Matthew R.

“…The FDA-approved glucagon-like-peptide-1 receptor (GLP-1R) agonists exendin-4 and liraglutide reduce food intake and body weight. Nausea is the most common…”
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Role of the glucagon-like-peptide-1 receptor in the control of energy balance by Hayes, Matthew R, De Jonghe, Bart C, Kanoski, Scott E

“…Abstract The peripheral and central glucagon-like-peptide-1 (GLP-1) systems play an essential role in glycemic and energy balance regulation. Thus,…”
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Excitatory Hindbrain-Forebrain Communication Is Required for Cisplatin-Induced Anorexia and Weight Loss by Alhadeff, Amber L, Holland, Ruby A, Zheng, Huiyuan, Rinaman, Linda, Grill, Harvey J, De Jonghe, Bart C

“…Cisplatin chemotherapy is commonly used to treat cancer despite severe energy balance side effects. In rats, cisplatin activates nucleus tractus solitarius…”
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Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation by Leon, Rosa M, Borner, Tito, Reiner, David J, Stein, Lauren M, Lhamo, Rinzin, De Jonghe, Bart C, Hayes, Matthew R

“…The overlap in neurobiological circuitry mediating the physiological and behavioral response to satiation and noxious/stressful stimuli are not well…”
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Creation of a Peptide Antagonist of the GFRAL–RET Receptor Complex for the Treatment of GDF15-Induced Malaise by Borner, Tito, Tinsley, Ian C., Milliken, Brandon T., Doebley, Sarah A., Najjar, Nicholas R., Kerwood, Deborah J., De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.

“…Growth differentiation factor 15 (GDF15) is a contributor to nausea, emesis, and anorexia following chemotherapy via binding to the GFRAL-RET receptor complex…”
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Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats by Leon, Rosa M., Borner, Tito, Stein, Lauren M., Urrutia, Norma A., De Jonghe, Bart C., Schmidt, Heath D., Hayes, Matthew R.

“…Within the hindbrain, serotonin (5-HT) functions as a modulator of the central glucagon-like peptide-1 (GLP-1) system. This interaction between 5-HT and GLP-1…”
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Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis by Borner, Tito, Workinger, Jayme L., Tinsley, Ian C., Fortin, Samantha M., Stein, Lauren M., Chepurny, Oleg G., Holz, George G., Wierzba, Aleksandra J., Gryko, Dorota, Nexø, Ebba, Shaulson, Evan D., Bamezai, Ankur, Da Silva, Valentina A. Rodriguez, De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.

“…Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired…”
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GIP receptor agonism blocks chemotherapy-induced nausea and vomiting by Borner, Tito, Reiner, Benjamin C., Crist, Richard C., Furst, C. Daniel, Doebley, Sarah A., Halas, Julia G., Ai, Minrong, Samms, Ricardo J., De Jonghe, Bart C., Hayes, Matthew R.

“…Nausea and vomiting remain life-threatening obstacles to successful treatment of chronic diseases, despite a cadre of available antiemetic medications. Our…”
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Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus) by De Jonghe, Bart C, Horn, Charles C

“…Cancer chemotherapy drugs, such as cisplatin, potently produce nausea and vomiting. Acute effects of these treatments are partly controlled by antiemetic…”
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Single nuclei RNA sequencing of the rat AP and NTS following GDF15 treatment by Reiner, Benjamin C., Crist, Richard C., Borner, Tito, Doyle, Robert P., Hayes, Matthew R., De Jonghe, Bart C.

“…Growth differentiation factor 15 (GDF15) is known to play a role in feeding, nausea, and body weight, with action through the GFRAL-RET receptor complex in the…”
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Hindbrain GLP-1 receptor mediation of cisplatin-induced anorexia and nausea by De Jonghe, Bart C, Holland, Ruby A, Olivos, Diana R, Rupprecht, Laura E, Kanoski, Scott E, Hayes, Matthew R

“…Abstract While chemotherapy-induced nausea and vomiting are clinically controlled in the acute (< 24 h) phase following treatment, the anorexia, nausea,…”
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Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons by Boccia, Lavinia, Borner, Tito, Ghidewon, Misgana Y., Kulka, Patricia, Piffaretti, Chiara, Doebley, Sarah A., De Jonghe, Bart C., Grill, Harvey J., Lutz, Thomas A., Le Foll, Christelle

“…The behavioral mechanisms and the neuronal pathways mediated by amylin and its long-acting analog sCT (salmon calcitonin) are not fully understood and it is…”
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Cisplatin induces neuronal activation and increases central AMPA and NMDA receptor subunit gene expression in mice by Holland, Ruby A, Leonard, John J, Kensey, Nicholas A, Hannikainen, Paavali A, De Jonghe, Bart C

“…Abstract Although rats and mice do not vomit, these species are widely studied as models of energy balance and sickness behavior. Previous work has shown that…”
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