Search Results - "De Falco, V"

Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression by Napolitano, S, Matrone, N, Muddassir, A L, Martini, G, Sorokin, A, De Falco, V, Giunta, E F, Ciardiello, D, Martinelli, E, Belli, V, Furia, M, Kopetz, S, Morgillo, F, Ciardiello, F, Troiani, T

“…Molecular mechanisms driving acquired resistance to anti-EGFR therapies in metastatic colorectal cancer (mCRC) are complex but generally involve the activation…”
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XB130, a tissue-specific adaptor protein that couples the RET PTC oncogenic kinase to PI 3-kinase pathway by Lodyga, M, De Falco, V, Bai, X-h, Kapus, A, Melillo, R M, Santoro, M, Liu, M

“…XB130 is a recently cloned 130 kDa-adaptor protein and Src kinase substrate, structurally similar to actin-filament-associated protein. Here we show that XB130…”
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Exploring higher order images with Fe Kα-lines from relativistic discs: black hole spin determination and bias by Falanga, M, Bakala, P, Placa, R La, De Falco, V, De Rosa, A, Stella, L

“…ABSTRACT We study the contributions to the relativistic Fe K α line profile from higher order images (HOIs) produced by strongly deflected rays from the disc…”
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How we treat locoregional melanoma by Troiani, T., De Falco, V., Napolitano, S., Trojaniello, C., Ascierto, P.A.

“…Cutaneous melanoma is the most lethal form of skin cancer and its incidence has been increasing in the past 30 years. Although this is completely resectable in…”
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Clinical practice use of liquid biopsy to identify RAS/BRAF mutational status in patients with metastatic colorectal cancer: A single institution experience by De Falco, V., Vitiello, P., Giunta, E., Ciardiello, D., Stefania, N., Cardone, C., Vitale, P., Zanaletti, N., Terminiello, M., Poliero, L., Borrelli, C., Caputo, V., Arrichiello, G., Mattera Iacono, V., Marrone, F., Famiglietti, V., Martinelli, E., Ciardiello, F., Troiani, T.

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Retrospective study of Regorafenib versus Trifluridine/Tipiracil efficacy in chemorefractory metastatic colorectal cancer patients: a single Italian institution real-life clinical data by Vitale, P., Zanaletti, N., Vitiello, P., martinelli, e., Ciardiello, D., De Falco, V., Giunta, E., Poliero, L., Terminiello, M., Borrelli, C., Caputo, V., Arrichiello, G., Martini, G., Stefania, N., Famiglietti, V., Cardone, C., Ciardiello, F., Troiani, T.

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A new natural compound identified through a metabolomic approach has cytotoxic activity against human colorectal cancer cell lines with acquired resistance to cetuximab by De Falco, V., Giunta, E.F., Belli, V., Matrone, N., Napolitano, S., Martinelli, E., Vitale, P., Zanaletti, N., Terminiello, M., Vitiello, P.P., Ciardiello, F., Troiani, T.

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Combined inhibition of MEK and PI3KCA pathway induces synergic antitumor activity in HER2 amplified human colorectal cancer models by Belli, V., Matrone, N., Napolitano, S., Martinelli, E., Castellone, M.D., Trusolino, L., Giunta, E.F., De Falco, V., Zanaletti, N., Vitiello, P.P., Ciardiello, D., Terminiello, M., Ciardiello, F., Troiani, T.

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Functional inhibition of TGF-β in colorectal cancer cells and its interaction with AXL receptor by Ciardiello, D., Martini, G., Matrone, N., Belli, V., Vitiello, P.P., Cardone, C., Ciaramella, V., Barra, G., Poliero, L., Borrelli, C., Troiani, T., Melisi, D., Morgillo, F., Giunta, E.F., De Falco, V., Ciardiello, F., Martinelli, E.

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Macrophage migration inhibitory factor overexpression is a mechanism of acquired resistance to anti-EGFR inhibitor cetuximab in human colorectal cancer cell line by Matrone, N., Chambery, A., Russo, R., Pedone, P.V., Belli, V., Napolitano, S., Martinelli, E., Giunta, E.F., De Falco, V., Zanaletti, N., Vitale, P., Terminiello, M., Cardone, C., Ciardiello, F., Troiani, T.

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Combination treatment with the PARP inhibitor niraparib and chemotherapeutics in a preclinical model of KRAS/BRAF mutated colorectal cancer cell lines across the four consensus molecular subtypes by Vitiello, P.P., Cardone, C., Ciardiello, D., Belli, V., Matrone, N., Borrelli, C., Poliero, L., De Falco, V., Giunta, E.F., Vitale, P., Zanaletti, N., Tirino, G., Troiani, T., Ciardiello, F., Martinelli, E.

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Identification of a highly suppressive Treg subset associated to immunotherapy response by Giunta, E.F., Romano, S., D'Arrigo, P., Rea, A., Tufano, M., Matarese, G., Procaccini, C., Novizio, N., Vigorito, V., Faicchia, D., Argenziano, G., De Falco, V., Ciardiello, F., Romano, M.F., Troiani, T.

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The acquired resistance to the combination of the anti-EGFR cetuximab and the MEK-inhibitor refametinib in KRAS mutated colorectal cancer cell lines depends on PI3K-signalling by Vitiello, P P, Viscardi, G, Martini, G, Cardone, C, Ciardiello, D, Belli, V, Matrone, N, Troiani, T, Napolitano, S, Sforza, V, De Falco, V, Giunta, E, Morgillo, F, Diadema, M R, Vitale, P, Zanaletti, N, Ciardiello, F, Martinelli, E

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EPHA2 receptor is involved in in vivo acquired resistance to anti-epidermal growth factor receptor (EGFR) treatment in metastatic colorectal cancer by Martini, G., Belli, V., Vitiello, P.P., Troiani, T., Cardone, C., Napolitano, S., Matrone, N., Sforza, V., Savastano, B., Renato, F., Morgillo, F., Della Corte, C.M., Ciardiello, D., Giunta, E.F., De Falco, V., Zanaletti, N., Vitale, P., Ciardiello, F., Martinelli, E.

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The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells by Vitagliano, Donata, De Falco, Valentina, Tamburrino, Anna, Coluzzi, Sabrina, Troncone, Giancarlo, Chiappetta, Gennaro, Ciardiello, Fortunato, Tortora, Giampaolo, Fagin, James A, Ryan, Anderson J, Carlomagno, Francesca, Santoro, Massimo

“…Oncogenic conversion of the RET tyrosine kinase is a frequent feature of medullary thyroid carcinoma (MTC). ZD6474 (vandetanib) is an ATP-competitive inhibitor…”
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Primary intraosseous carcinoma of the mandible: a case report by Lo Muzio, L, Mangini, F, De Falco, V, Pennella, A, Farronato, G

“…A case of primary intraosseous carcinoma of the mandible in a 75-year-old man is reported. This tumor is an uncommon lesion arising from odontogenic rests…”
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Biochemical and molecular characterization of the novel BRAF mutation detected in a classic papillary thyroid carcinoma by Moretti, S, Macchiarulo, A, De Falco, V, Avenia, N, Barbi, F, Carta, C, Cavaliere, A, Melillo, R M, Passeri, L, Santeusanio, F, Tartaglia, M, Santoro, M, Puxeddu, E

“…Activating mutations of the BRAF gene are the most common genetic alterations in papillary thyroid carcinomas (PTCs) and the T1799A transversion, resulting in…”
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Biochemical and molecular characterization of the novel BRAFV599Ins mutation detected in a classic papillary thyroid carcinoma by MORETTI, S, MACCHIARULO, A, TARTAGLIA, M, SANTORO, M, PUXEDDU, E, DE FALCO, V, AVENIA, N, BARBI, F, CARTA, C, CAVALIERE, A, MELILLO, R. M, PASSERI, L, SANTEUSANIO, F

“…Activating mutations of the BRAF gene are the most common genetic alterations in papillary thyroid carcinomas (PTCs) and the T1799A transversion, resulting in…”
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Effect of impact load and active load on bone metabolism and body composition of adolescent athletes by LIMA, Fernanda, DE FALCO, Valéria, BAIMA, Jader, CARAZZATO, Joao Gilberto, PEREIRA, Rosa M. R

“…It is unclear whether adolescents involved in nonweight-bearing activities experience a delay in bone growth acquisition and sexual maturation. The purpose of…”
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Phaces syndrome with intraoral and perioral hemangiomas: a different approach with Diode Laser by Tempesta, A, Limongelli, L, De Falco, V, Petruzzi, M, Favia, G

“…PHACES is an acronym which refers to a syndrome charachterized by Posterior cranial fossa malformation, Hemangiomas of the head, Arterial abnormalities,…”
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