Search Results - "De Brabander, Jef"

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection by Lu, Feiran, Liang, Qiren, Abi-Mosleh, Lina, Das, Akash, De Brabander, Jef K, Goldstein, Joseph L, Brown, Michael S

“…Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor-mediated uptake of LDL, and it also mediates cellular…”
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Structural basis for itraconazole-mediated NPC1 inhibition by Long, Tao, Qi, Xiaofeng, Hassan, Abdirahman, Liang, Qiren, De Brabander, Jef K., Li, Xiaochun

“…Niemann-Pick C1 (NPC1), a lysosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, exports low-density-lipoprotein (LDL)-derived…”
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Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma by Shi, Yufeng, Lim, S. Kyun, Liang, Qiren, Iyer, Swathi V., Wang, Hua-Yu, Wang, Zilai, Xie, Xuanhua, Sun, Daochun, Chen, Yu-Jung, Tabar, Viviane, Gutin, Philip, Williams, Noelle, De Brabander, Jef K., Parada, Luis F.

“…Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare. Here we describe Gboxin, a small molecule that specifically…”
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Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK‐925 and ARN‐776 in narcoleptic orexin/tTA; TetO‐DTA mice by Sun, Yu, Ranjan, Alok, Tisdale, Ryan, Ma, Shun‐Chieh, Park, Sunmee, Haire, Meghan, Heu, Jasmine, Morairty, Stephen R., Wang, Xiaoyu, Rosenbaum, Daniel M., Williams, Noelle S., De Brabander, Jef K., Kilduff, Thomas S.

“…Summary The sleep disorder narcolepsy, a hypocretin deficiency disorder thought to be due to degeneration of hypothalamic hypocretin/orexin neurons, is…”
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Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer by Kim, Hyun Seok, Mendiratta, Saurabh, Kim, Jiyeon, Pecot, Chad Victor, Larsen, Jill E., Zubovych, Iryna, Seo, Bo Yeun, Kim, Jimi, Eskiocak, Banu, Chung, Hannah, McMillan, Elizabeth, Wu, Sherry, De Brabander, Jef, Komurov, Kakajan, Toombs, Jason E., Wei, Shuguang, Peyton, Michael, Williams, Noelle, Gazdar, Adi F., Posner, Bruce A., Brekken, Rolf A., Sood, Anil K., Deberardinis, Ralph J., Roth, Michael G., Minna, John D., White, Michael A.

“…Context-specific molecular vulnerabilities that arise during tumor evolution represent an attractive intervention target class. However, the frequency and…”
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Molecular mechanism of the wake-promoting agent TAK-925 by Yin, Jie, Kang, Yanyong, McGrath, Aaron P., Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K., Rosenbaum, Daniel M.

“…The OX 2 orexin receptor (OX 2 R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in…”
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Triazoles inhibit cholesterol export from lysosomes by binding to NPC1 by Trinh, Michael N., Lu, Feiran, Li, Xiaochun, Das, Akash, Liang, Qiren, De Brabander, Jef K., Brown, Michael S., Goldstein, Joseph L.

“…Niemann–Pick C1 (NPC1), amembrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. Lysosomal…”
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Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer by Zhang, Lu, Theodoropoulos, Panayotis C, Eskiocak, Ugur, Wang, Wentian, Moon, Young-Ah, Posner, Bruce, Williams, Noelle S, Wright, Woodring E, Kim, Sang Bum, Nijhawan, Deepak, De Brabander, Jef K, Shay, Jerry W

“…Mutations in the adenomatous polyposis coli (APC) gene are common in colorectal cancer (CRC), and more than 90% of those mutations generate stable truncated…”
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Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A by Jiang, Xin, Liu, Bo, Lebreton, Sylvain, De Brabander, Jef K

“…We describe a highly convergent and flexible synthesis of the novel antarctic marine metabolite palmerolide Aan effort leading to a reformulation of…”
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Reply to: The G protein preference of orexin receptors is currently an unresolved issue by Yin, Jie, Kang, Yanyong, McGrath, Aaron P., Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K., Rosenbaum, Daniel M.

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A Concise Synthesis of Berkelic Acid Inspired by Combining the Natural Products Spicifernin and Pulvilloric Acid by Bender, Christopher F., Yoshimoto, Francis K., Paradise, Christopher L., Brabander, Jef K. De

“…We describe a concise synthesis of the structurally novel fungal extremophile metabolite berkelic acid, an effort leading to an unambiguous assignment of C22…”
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Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B by Feng, Yu, Liu, Jun, Carrasco, Yazmin P, MacMillan, John B, De Brabander, Jef K

“…We describe the isolation, structure elucidation, and total synthesis of the novel marine natural product rifsaliniketal and the total synthesis of the…”
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Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles by Bimbo, Luis M, Denisova, Oxana V, Mäkilä, Ermei, Kaasalainen, Martti, De Brabander, Jef K, Hirvonen, Jouni, Salonen, Jarno, Kakkola, Laura, Kainov, Denis, Santos, Hélder A

“…Influenza A viruses (IAVs) cause recurrent epidemics in humans, with serious threat of lethal worldwide pandemics. The occurrence of antiviral-resistant virus…”
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Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters by Brabander, Jef K. De, Liu, Bo, Qian, Mingxing

“…Depending on the nature of the metal catalyst, ω-hydroxy propargylic acetates choose between alternative cycloetherification manifolds to produce…”
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Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs by Adams, Christopher M, Reitz, Julian, De Brabander, Jef K, Feramisco, Jamison D, Li, Lu, Brown, Michael S, Goldstein, Joseph L

“…The current paper demonstrates that cholesterol and its hydroxylated derivative, 25-hydroxycholesterol (25-HC), inhibit cholesterol synthesis by two different…”
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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma by Eskiocak, Banu, McMillan, Elizabeth A, Mendiratta, Saurabh, Kollipara, Rahul K, Zhang, Hailei, Humphries, Caroline G, Wang, Changguang, Garcia-Rodriguez, Jose, Ding, Ming, Zaman, Aubhishek, Rosales, Tracy I, Eskiocak, Ugur, Smith, Michael P, Sudderth, Jessica, Komurov, Kakajan, Deberardinis, Ralph J, Wellbrock, Claudia, Davies, Michael A, Wargo, Jennifer A, Yu, Yonghao, De Brabander, Jef K, Williams, Noelle S, Chin, Lynda, Rizos, Helen, Long, Georgina V, Kittler, Ralf, White, Michael A

“…Genomic diversity among melanoma tumors limits durable control with conventional and targeted therapies. Nevertheless, pathologic activation of the ERK1/2…”
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Structural insights for selective disruption of Beclin 1 binding to Bcl-2 by Pan, Yun-Zu, Liang, Qiren, Tomchick, Diana R., De Brabander, Jef K., Rizo, Josep

“…Stimulation of autophagy could provide powerful therapies for multiple diseases, including cancer and neurodegeneration. An attractive drug target for this…”
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Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines by Straud, Sarah, Zubovych, Iryna, De Brabander, Jef K, Roth, Michael G

“…Many cell lines derived from tumors as well as transformed cell lines are far more sensitive to V-ATPase inhibitors than normal counterparts. The molecular…”
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Lessons and revelations from biomimetic syntheses by Razzak, Mina, De Brabander, Jef K

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Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes by Kissing, Sandra, Rudnik, Sönke, Damme, Markus, Lüllmann-Rauch, Renate, Ichihara, Atsuhiro, Kornak, Uwe, Eskelinen, Eeva-Liisa, Jabs, Sabrina, Heeren, Jörg, De Brabander, Jef K., Haas, Albert, Saftig, Paul

“…The vacuolar-type H + -translocating ATPase (v-H + -ATPase) has been implicated in the amino acid-dependent activation of the mechanistic target of rapamycin…”
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